Molecular epidemiology of echovirus 30 in Fujian, China between 2001 and 2011
Abstract
Echovirus 30 (E-30) was responsible for an outbreak of aseptic meningitis between April 1 and June 2, 2011 in Fujian Province, China. A molecular epidemiology study of 115 E-30 strains was performed to characterize the genetic features of the etiologic agent of the 2011 aseptic meningitis outbreak. The phylogenetic trees of the complete VP1 gene (876 bp) from 74 of 115 isolates and 50 reference sequences were analyzed. Three lineages (E-30_h, i, and j) were detected that had co-circulated in Fujian in the last decade, of which E-30_j was new. The other 72 Fujian strains and 16 representative strains from other provinces of China all belong to E-30_h and E-30_i. Two distinct E-30 clusters including virus isolates obtained during adult surveillance were associated with the 2011 outbreak and differed from Fujian isolates prior to 2011, suggesting that the viruses may vary and adult infections play an important role in viral transmission. Thus, the multiple lineages of E-30 in Fujian and variant viruses enhanced transmissibility, which may be related to the epidemic activity of E-30.
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In China, documented E30 associated aseptic meningitis outbreaks occurred in Shandong and Jiangsu in 2003 and Fujian in 2011.
“In China, the documented E30 associated aseptic meningitis outbreak occurred in the provinces of Shandong and Jiangsu in 2003 and Fujian in 2011 [3], [8], [35].”
From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [35]
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- Authors
- Yang, X., Yan, Y., Weng, Y., He, A., Zhang, H., Chen, W., & Zhou, Y.
- ORCID
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2013-01-28
- Volume
- 85
- Issue
- 4
- Pages
- 696-702
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W2120505686
- Cited by
- 22
- References
- 32
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 9 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- echovirus 30, molecular epidemiology, viral lineages, adult infection, virus transmission, Fujian
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, China, Disease Outbreaks, Echovirus Infections, Female, Humans, Infant, Infant, Newborn, Male, Meningitis, Aseptic, Middle Aged, Molecular Sequence Data, Phylogeny, RNA, Viral, Genetic Variation, Viral Structural Proteins, Cluster Analysis, Sequence Analysis, DNA, Molecular Epidemiology, Enterovirus B, Human, Young Adult
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