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Cited by 155Viral Infections and Immunology ResearchEvolution and Genetic DynamicsVirology and Viral Diseases

Molecular epidemiology and genetic diversity of echovirus type 30 (E30): genotypes correlate with temporal dynamics of E30 isolation

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Oberste, M. Steven, Maher, Kaija, Kennett, Margery L., Campbell, Janice J., Carpenter, Michael S., Schnurr, David, Pallansch, Mark A.·1999·Journal of Clinical Microbiology
DOI 10.1128/jcm.37.12.3928-3933.1999PMC PMC85848
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Abstract

Echovirus type 30 (E30) (genus, Enterovirus; family, Picornaviridae) has caused large outbreaks of aseptic meningitis in many regions of the world in the last 40 years. U.S. enterovirus surveillance data for the period 1961 to 1998 indicated that the annual proportion of E30 isolations relative to total enterovirus isolations has fluctuated widely, from a low of 0% in 1966 to a high of 42% in 1998. Peaks of E30 isolations occurred in the years 1968 to 1969, 1981 to 1984, 1990 to 1993, and 1997 to 1998, coincident with large nationwide outbreaks of E30-associated aseptic meningitis. Analysis of the complete VP1 sequence (876 nucleotides) of 136 E30 strains isolated in geographically dispersed regions of the United States and nine other countries between 1956 and 1998 indicated that the currently circulating E30 strains are genetically distinct from those isolated 30 to 40 years ago. Phylogenetic reconstruction demonstrated the existence of at least four distinct genetic groups, three of which have not been isolated in North America since 1981. Two of the three groups disappeared during periods when E30 was isolated infrequently. All North American E30 strains isolated after 1988 were closely related to one another, and all post-1993 isolates were of the same lineage within this group. Surveillance data indicate that E30 causes large national outbreaks of 2- to 4-year durations, separated by periods of relative quiescence. Our results show that shifts in the overall genetic diversity of E30 and the predominant genetic type correlate temporally with the dynamics of E30 isolation. The sequence data also provide a basis for the application of molecular techniques for future epidemiologic investigations of E30 disease.

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  • E30 is one of the most frequently isolated serotypes in many regions of the world and has caused many large outbreaks of aseptic meningitis in the last 40 years.

    “E30 is one of the most frequently isolated serotype in many regions of the world and has caused many large outbreaks of aseptic meningitis in the last 40 years [2].”

    From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [2]

    The Abstract says E30 caused large outbreaks of aseptic meningitis in many regions of the world over the preceding 40 years. It calls E30 one of the most frequently isolated enteroviruses in the United States, but does not establish that it was among the most frequently isolated in many regions worldwide. (LLM, conf=0.86)

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  • HEVs are the major causative agents of aseptic meningitis in many parts of the world.

    “HEVs are the major causative agents of aseptic meningitis in many parts of the world, and numerous HEV associated aseptic meningitis epidemics and outbreaks have been described [1], [2].”

    From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [2]

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Research works printed but not linked: 4

  1. [1]Center for Disease Control. Neurotropic viral diseases surveillance. Enterovirus infections. No. 1 annual summary. U.S. Atlanta, Ga: Department of Health, Education, and Welfare; 1970. [Google Scholar]
  2. [9]Genetics Computer Group, Inc. Wisconsin sequence analysis package, version 9.1. Madison, Wis: Genetics Computer Group, Inc.; 1998. [Google Scholar]
  3. [18]Likosky W H, Emmons R W, Davis L E, Thompson R S. Epidemiology of echovirus 30 aseptic meningitis. Health Serv Rep. 1972;87:638–642. [PMC free article] [PubMed] [Google Scholar]
  4. [21]National Communicable Diseases Center. Annual summary—1968. Aseptic meningitis and non-polio enteroviruses. Atlanta, Ga: U.S. Department of Health, Education, and Welfare; 1969. [Google Scholar]

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Authors
Oberste, M. S., Maher, K., Kennett, M. L., Campbell, J. J., Carpenter, M. S., Schnurr, D., & Pallansch, M. A.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • Victorian Infectious Diseases Reference Laboratory (AU)
  • <!--label omitted: 3-->National Centre for Enteroviruses, Halifax, Nova Scotia, Canada3 and
  • California Health and Human Services Agency (US)
ORCID
Venue
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Published
1999-12
Volume
37
Issue
12
Pages
3928-3933
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
DOI
10.1128/jcm.37.12.3928-3933.1999
PMC
PMC85848
OpenAlex
W1787418790
Cited by
154
References
27
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 14 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 6
FWCI
2.91
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
aseptic meningitis, genetic diversity, phylogenetic analysis, enterovirus surveillance, outbreak epidemiology, molecular epidemiology, North America
MeSH terms
Canada, Echovirus Infections, Genotype, Humans, Meningitis, Aseptic, Molecular Sequence Data, Phylogeny, United States, Genetic Variation, Viral Proteins, Sequence Analysis, DNA, Reverse Transcriptase Polymerase Chain Reaction, Enterovirus B, Human

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