The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Differential expression of the “C” and “T” alleles of the 5‐HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics
Abstract
A genetic association between schizophrenia and a silent C/T(102) polymorphism in the 5‐HT2A receptor gene (5‐HT2AR) has been previously reported; however, the mechanisms underlying this association remain unknown. Here we developed an improved quantitative assay for measurements of allele ratios, which revealed that the expression of allele “C” in the temporal cortex of normal heterozygous individuals was significantly lower than the expression of allele “T” (allele “C” to allele “T” ratio of ∼0.8, P < 0.0001). Confirming decreased expression of allele “C,” total levels of 5‐HT2AR mRNA and protein in normal individuals with the C/C genotype were lower than in individuals with the T/T genotype. Similarly to normal individuals, allele “C” to allele “T” ratio in heterozygous schizophrenics was reduced (∼0.8, P < 0001). This ratio was independent of neuroleptic treatment history. By contrast, total levels of 5‐HT2AR mRNA correlated inversely with neuroleptic free interval prior to death (r = −0.67, P < 0.001) suggesting a reversible neuroleptic effect. Total levels 5‐HT2AR mRNA in neuroleptic free (> 26 weeks) schizophrenics (n = 11) were significantly lower than in controls (P = 0.03). The data suggest that increased prevalence of allele “C” among schizophrenics may be due to intrinsically low expression of this allele, which may contribute to a deficit in 5‐HT2AR expression in some schizophrenics. Published 2002 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Stanley Foundation brain collection and Neuropathology Consortium
Torrey, E. F., Webster, M., Knable, M., Johnston, N., & Yolken, R. H. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00192-9 · Cited by 533
The Mechanism of Action of Novel Antipsychotic Drugs
Meltzer, H. Y. (1991) · Schizophrenia Bulletin · doi:10.1093/schbul/17.2.263 · Cited by 411
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics
Joyce, J. N., Shane, A., Lexow, N., Winokur, A., Casanova, M. F., & Kleinman, J. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.32 · Cited by 340
Burnet, P. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00053-x · Cited by 286
Turecki, G., Brière, R., Dewar, K., Antonetti, T., Lesage, A. D., Séguin, M., Chawky, N., Vanier, C., Alda, M., Joober, R., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1456 · Cited by 276
Spurlock, G., Heils, A., Holmans, P., Williams, J., D'Souza, U. M., Cardno, A., Murphy, K. C., Jones, L., Buckland, P. R., McGuffin, P., et al. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000342 · Cited by 254
Neurotransmitter Receptors in Frontal Cortex of Schizophrenics
Bennett, J. P. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780090013001 · Cited by 248
European Multicentre Association Study of Schizophrenia (EMASS) Group, Williams, J., Spurlock, G., McGuffin, P., Owen, M. J., Mallet, J., Nöthen, M. M., Gill, M., Aschauer, H., Nylander, P.-O., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90939-3 · Cited by 246
Selective Abnormalities of Prefrontal Serotonergic Receptors in Schizophrenia: A Postmortem Study
Laruelle, M. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820220066007 · Cited by 233
Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics
Mita, T., Hanada, S., Nishino, N., Kuno, T., Nakai, H., Yamadori, T., Mizoi, Y., & Tanaka, C. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90332-x · Cited by 222
Cited by
Bousman, C. A., Stevenson, J. M., Ramsey, L. B., Sangkuhl, K., Hicks, J. K., Strawn, J. R., Singh, A. B., Ruaño, G., Mueller, D. J., Tsermpini, E. E., et al. (2023) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2903 · Cited by 521
Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder
Kato, M., & Serretti, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.116 · Cited by 450
Aston, C., Jiang, L., & Sokolov, B. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001565 · Cited by 427
Self-citationAyalew, M., Le-Niculescu, H., Levey, D. F., Jain, N., Changala, B., Patel, S. D., Winiger, E., Breier, A., Shekhar, A., Amdur, R., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.37 · Cited by 397
Personalized medicine in psychiatry: problems and promises
Ozomaro, U., Wahlestedt, C., & Nemeroff, C. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-132 · Cited by 270
Metadata
- Authors
- Polesskaya, O. O., & Sokolov, B. P.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2002-02-07
- Volume
- 67
- Issue
- 6
- Pages
- 812-822
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1999265734
- Cited by
- 277
- References
- 36
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Differential expression of the “C” and “T” alleles of the 5‐HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. https://app.cochat.ai/papers/10.1002/jnr.10173
- The paper
- Polesskaya, O. O., & Sokolov, B. P. (2002). Differential expression of the “C” and “T” alleles of the 5‐HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.10173
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
