The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Prediction of Level of Serotonin 2A Receptor Binding by Serotonin Receptor 2A Genetic Variation in Postmortem Brain Samples From Subjects Who Did or Did Not Commit Suicide
Abstract
OBJECTIVE: Postmortem studies have indicated that suicide victims have greater serotonin receptor 2A (5-HTR2A) binding in prefrontal brain regions. However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized that the variance observed in brain 5-HTR2A binding is genetically mediated, at least in part. METHOD: Postmortem data from 56 subjects who had committed suicide and 126 normal comparison subjects were studied; brain tissue was available from 11 subjects who committed suicide and 11 comparison subjects. Homogenate binding assays were carried out with [3H]ketanserin. Variation at the 5-HTR2A gene (HTR2A) was investigated by means of two polymorphisms: T102C and A-1438G. RESULTS: 5-HTR2A binding was greater in the prefrontal cortex of the subjects who committed suicide. In addition, the findings suggest that HTR2A variation significantly affects 5-HTR2A binding. However, no interaction between suicidal behavior and this locus was observed. CONCLUSIONS: These results confirm previous reports of greater 5-HTR2A binding in subjects who committed suicide; they also provide preliminary evidence suggesting that the number of 5-HTR2A receptors is genetically mediated.
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Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims
Mann, J. J. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800100048007 · Cited by 547
INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS
Stanley, M., & Mann, J. J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92590-4 · Cited by 529
Mann, J. (1998) · Nature Medicine · doi:10.1038/nm0198-025 · Cited by 472
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A Tryptophan Hydroxylase Gene Marker for Suicidality and Alcoholism
Nielsen, D. A., Virkkunen, M., Lappalainen, J., Eggert, M., Brown, G. L., Long, J. C., Goldman, D., & Linnoila, M. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.593 · Cited by 293
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Cited by
Dube, S. R., Anda, R. F., Felitti, V. J., Chapman, D. P., Williamson, D. F., & Giles, W. H. (2001) · JAMA · doi:10.1001/jama.286.24.3089 · Cited by 2,296
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739
Gene–environment interaction analysis of serotonin system markers with adolescent depression
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., Plomin, R., & Craig, I. W. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001546 · Cited by 663
The Psychology and Neurobiology of Suicidal Behavior
Joiner, T. E., Brown, J. S., & Wingate, L. R. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070320 · Cited by 481
Metadata
- Authors
- Turecki, G., Brière, R., Dewar, K., Antonetti, T., Lesage, A. D., Séguin, M., Chawky, N., Vanier, C., Alda, M., Joober, R., Benkelfat, C., & Rouleau, G. A.
- Venue
- American Journal of Psychiatry
- Published
- 1999-09-01
- Volume
- 156
- Issue
- 9
- Pages
- 1456-1458
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1899399637
- Cited by
- 276
- References
- 13
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prediction of Level of Serotonin 2A Receptor Binding by Serotonin Receptor 2A Genetic Variation in Postmortem Brain Samples From Subjects Who Did or Did Not Commit Suicide. https://app.cochat.ai/papers/10.1176/ajp.156.9.1456
- The paper
- Turecki, G., Brière, R., Dewar, K., Antonetti, T., Lesage, A. D., Séguin, M., Chawky, N., Vanier, C., Alda, M., Joober, R., Benkelfat, C., & Rouleau, G. A. (1999). Prediction of Level of Serotonin 2A Receptor Binding by Serotonin Receptor 2A Genetic Variation in Postmortem Brain Samples From Subjects Who Did or Did Not Commit Suicide. American Journal of Psychiatry. https://doi.org/10.1176/ajp.156.9.1456
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