Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer’s disease
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To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and control subjects. The concentration of 8-OHG in CSF in AD patients was approximately fivefold that in controls (P < 0.001). The concentration of 8-OHG in CSF decreased significantly with the duration of illness (r(s) = -0.48, P < 0.05) and the progression of cognitive dysfunctions (r(s) = 0.67, P < 0.01). However, the concentration of 8-OHG in CSF showed no correlation with that in serum in both the controls and AD patients. In addition, the concentration of 8-OHG in serum was not significantly altered in AD patients compared to that in controls, suggesting that the 8-OHG concentrations in the CSF do not reflect those in serum and may be probably reflect those in brain tissue. These in vivo findings suggest a possible role of 8-OHG and increased oxidative RNA damage in the early stage of the development of AD.
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Oxidation of DNA and RNA produced by reactive oxygen species occurs in Alzheimer's disease.
“Oxidation of DNA and RNA produced by ROS also occurs in AD [50,51,52,53].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [52]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, 5th Edition
(2013) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890425596.893619 · Cited by 4,390 · see citing works
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186 · see citing works
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works
Oxidative stress and Alzheimer disease
Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,158 · see citing works
Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders
Floyd, R. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-140.x · Cited by 824 · see citing works
Oxidative Alterations in Alzheimer's Disease
Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789 · see citing works
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
Nunomura, A., Perry, G., Pappolla, M., Wade, R., Hirai, K., Chiba, S., & Smith, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01959.1999 · Cited by 768 · see citing works
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
Shigenaga, M. K., Gimeno, C. J., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9697 · Cited by 732 · see citing works
Lin, C.-L., Bristol, L. A., Jin, L., Dykes‐Hoberg, M., Crawford, T. O., Clawson, L., & Rothstein, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80997-6 · Cited by 672 · see citing works
Zhang, J., Perry, G. L., Smith, M. A., Robertson, D., Olson, S. J., Graham, D. G., & Montine, T. J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65396-5 · Cited by 636 · see citing works
Production of superoxide anions by a CNS macrophage, the microglia
Colton, C. A., & Gilbert, D. L. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80305-8 · Cited by 614 · see citing works
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
van Leeuwen, F. W., de Kleijn, D. P. V., van den Hurk, H., Neubauer, A., Sonnemans, M. A. F., Sluijs, J. A., Köycü, S., Ramdjielal, R. D. J., Salehi, A., Martens, G. J. M., et al. (1998) · Science · doi:10.1126/science.279.5348.242 · Cited by 561 · see citing works
Akama, K. T., Albanese, C., Pestell, R. G., & Eldik, L. J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5795 · Cited by 348 · see citing works
Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome
Nunomura, A., Perry, G. L., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.11.1011 · Cited by 322 · see citing works
Oxidative Damage to Nucleic Acids Photosensitized by Titanium Dioxide
Wamer, W. G., Yin, J., & Wei, R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00068-3 · Cited by 310 · see citing works
Counteraction by MutT protein of transcriptional errors caused by oxidative damage.
Taddei, F., Hayakawa, H., Bouton, M., Cirinesi, A.-M., Matic, I., Sekiguchi, M., & Radman, M. (1997) · Science · doi:10.1126/science.278.5335.128 · Cited by 290 · see citing works
Fiala, E. S., Conaway, C. C., & Mathis, J. (1989) · PubMed · Cited by 254 · see citing works
Tohgi, H., Abe, T., Yamazaki, K., Murata, T., Ishizaki, E., & Isobe, C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00406-1 · Cited by 173 · see citing works
Self-citationIn vitro Photooxidation of Nucleic Acids by Ultraviolet A Radiation
Warner, W. G., & Wei, R. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08605.x · Cited by 79 · see citing works
Oxidative base damage in RNA detected by reverse transcriptase
Rhee, Y., Valentine, M. R., & Termini, J. S. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.16.3275 · Cited by 73 · see citing works
Dani, S. U., Hori, A., & Walter, G. (1997) · Medical Entomology and Zoology · Cited by 54 · see citing works
Benzing, W. C., & Mufson, E. (1995) · Brain Research · doi:10.1016/0006-8993(94)01362-l · Cited by 51 · see citing works
Sayre, L. M., Perry, G. L., & Smith, M. A. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)09012-6 · Cited by 49 · see citing works
Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease
Smith, M. A., Hirai, K., Nunomura, A., & Perry, G. L. (1999) · Drug Development Research · doi:10.1002/(sici)1098-2299(199901)46:1 · Cited by 17 · see citing works
RNA Oxidation in Alzheimer and Parkinson Diseases
Nunomura, A., Perry, G. L., Zhang, J., Montine, T. J., Takeda, A., Chiba, S., & Smith, M. A. (1999) · Rejuvenation Research · doi:10.1089/rej.1.1999.2.227 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-014-0446-0 · Cited by 2,886 · see citing works
Free Radical Properties, Source and Targets, Antioxidant Consumption and Health
Martemucci, G., Costagliola, C., Mariano, M., D’Andrea, L., Napolitano, P., & D‘Alessandro, A. G. (2022) · Oxygen · doi:10.3390/oxygen2020006 · Cited by 781 · see citing works
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
Perrin, R. J., Fagan, A. M., & Holtzman, D. M. (2009) · Nature · doi:10.1038/nature08538 · Cited by 702 · see citing works
Involvement of oxidative stress in Alzheimer disease
Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611 · see citing works
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564 · see citing works
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View
Cenini, G., Lloret, A., & Cascella, R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2105607 · Cited by 435 · see citing works
Oxidative damage to RNA: mechanisms, consequences, and diseases
Kong, Q., & Lin, C. G. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0277-y · Cited by 350 · see citing works
Oxidative stress in Alzheimer's disease
Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 341 · see citing works
Role of Oxidative Stress in the Progression of Alzheimer's Disease
Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 327 · see citing works
Increased lipid peroxidation in sera of ALS patients
Simpson, E. P., Henry, Y. K., Henkel-Tigges, J., Smith, R. G., & Appel, S. H. (2004) · Neurology · doi:10.1212/wnl.62.10.1758 · Cited by 328 · see citing works
Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
Persson, T., Popescu, B. O., & Cedazo-Mı́nguez, Á. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/427318 · Cited by 318 · see citing works
A deep learning method for predicting metabolite–disease associations via graph neural network
Sun, F., Sun, J., & Zhao, Q. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac266 · Cited by 274 · see citing works
Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment
Mangialasche, F., Polidori, M. C., Monastero, R., Ercolani, S., Camarda, C., Cecchetti, R., & Mecocci, P. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.002 · Cited by 247 · see citing works
Markers of oxidant stress that are clinically relevant in aging and age-related disease
Jacob, K. D., Hooten, N. N., Trzeciak, A. R., & Evans, M. K. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.02.008 · Cited by 233 · see citing works
Biomarkers of Oxidative Damage and Inflammation in Alzheimer's Disease
Galasko, D. R., & Montine, T. J. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.89 · Cited by 221 · see citing works
RNA modifications by oxidation: A novel disease mechanism?
Poulsen, H. E., Specht, E., Broedbaek, K., Henriksen, T., Ellervik, C., Mandrup-Poulsen, T. R., Tonnesen, M., Nielsen, P. E., Andersen, H. U., & Weimann, A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.009 · Cited by 211 · see citing works
RNA damage and surveillance under oxidative stress
Li, Z., Wu, J., & DeLeo, C. J. (2006) · IUBMB Life · doi:10.1080/15216540600946456 · Cited by 194 · see citing works
Oxidative Damage to RNA in Aging and Neurodegenerative Disorders
Nunomura, A., Moreira, P. I., Castellani, R. J., Lee, H., Zhu, X., Smith, M. A., & Perry, G. L. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9331-x · Cited by 184 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid
Poulsen, H. E., Llovera, L., Broedbaek, K., Nielsen, P. E., & Weimann, A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.009 · Cited by 162 · see citing works
Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 152 · see citing works
RNA oxidation in Alzheimer disease and related neurodegenerative disorders
Nunomura, A., Hofer, T., Moreira, P. I., Castellani, R. J., Smith, M. A., & Perry, G. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0508-1 · Cited by 148 · see citing works
Hofer, T., Seo, A. Y., Prudencio, M., & Leeuwenburgh, C. (2006) · Biological Chemistry · doi:10.1515/bc.2006.014 · Cited by 144 · see citing works
Target Identification for CNS Diseases by Transcriptional Profiling
Altar, C. A., Vawter, M. P., & Ginsberg, S. D. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.172 · Cited by 139 · see citing works
Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138 · see citing works
Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura, A., Honda, K., Takeda, A., Hirai, K., Zhu, X., Smith, M. A., & Perry, G. L. (2006) · BioMed Research International · doi:10.1155/jbb/2006/82323 · Cited by 129 · see citing works
Mitochondrial dysfunction and Alzheimer's disease
Maruszak, A., & Żekanowski, C. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.004 · Cited by 123 · see citing works
Upcoming Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease
Fagan, A. M., & Perrin, R. J. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.42 · Cited by 115 · see citing works
Alzheimer’ s disease, oxidative stress and gammahydroxybutyrate
Mamelak, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.008 · Cited by 108 · see citing works
Environmental and dietary risk factors in Alzheimer’s disease
Dosunmu, R., Wu, J., Basha, R. M., & Zawia, N. H. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.7.887 · Cited by 109 · see citing works
Multimarker Screening of Oxidative Stress in Aging
Syslová, K., Böhmová, A., Mikoška, M., Kuzma, M., Pelclová, D., & Kačer, P. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/562860 · Cited by 102 · see citing works
Tchekalarova, J. D., & Tzoneva, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24033022 · Cited by 100 · see citing works
The oxidative damage theory of aging
Lin, M. T., & Flint Beal, M. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00007-0 · Cited by 89 · see citing works
Blood markers of oxidative stress in A lzheimer's disease
Skoumalová, A., & Hort, J. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01585.x · Cited by 87 · see citing works
The Possible Role of Antioxidant Vitamin C in Alzheimer’s Disease Treatment and Prevention
Heo, J., Lee, H., & Lee, K. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512473193 · Cited by 79 · see citing works
Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Cervellati, C., Wood, P. L., Romani, A., Valacchi, G., Squerzanti, M., Sanz, J. M., Ortolani, B., & Zuliani, G. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2015-000017 · Cited by 75 · see citing works
Association Between Urinary Markers of Nucleic Acid Oxidation and Mortality in Type 2 Diabetes
Broedbaek, K., Siersma, V., Henriksen, T., Weimann, A., Petersen, M. A., Andersen, J. T., Jimenez‐Solem, E., Hansen, L. J., Henriksen, J. E., Bonnema, S. J., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0998 · Cited by 73 · see citing works
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73 · see citing works
Modifiable, Non-Modifiable, and Clinical Factors Associated with Progression of Alzheimer’s Disease
Loeffler, D. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201182 · Cited by 67 · see citing works
Puentes-Díaz, N., Chaparro, D., Morales-Morales, D., Flores-Gaspar, A., & Alí-Torres, J. (2023) · ACS Omega · doi:10.1021/acsomega.2c06939 · Cited by 67 · see citing works
Biochemical Markers and Risk Factors of Alzheimers Disease
Flirski, M., & Sobów, T. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772704 · Cited by 67 · see citing works
Chu, J.-M., Qi, C., Huang, Y., Jiang, H.-P., Hao, Y., Yuan, B., & Feng, Y. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01614 · Cited by 66 · see citing works
Ascorbic acid protects SH-SY5Y neuroblastoma cells from apoptosis and death induced by β-amyloid
Huang, J., & May, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.047 · Cited by 66 · see citing works
Mild Cognitive Impairment and Alzheimer Patients Display Different Levels of Redox-Active CSF Iron
Manuel Lavados, M., Guillón, M., Mujica, M. C., Rojo, L. E., Fuentes, P., & Maccioni, R. B. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13211 · Cited by 61 · see citing works
Lee, S. H., Jung, B. H., Kim, S. Y., & Chung, B. C. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1400 · Cited by 57 · see citing works
Jiang, H.-P., Qi, C., Chu, J.-M., Yuan, B., & Feng, Y. (2015) · Scientific Reports · doi:10.1038/srep07785 · Cited by 57 · see citing works
Antioxidant capacity and protein oxidation in cerebrospinal fluid of amyotrophic lateral sclerosis
Siciliano, G., Piazza, S., Carlesi, C., Corona, A., Franzini, M., Alfonso Pompella, C., Malvaldi, G., Mancuso, M., Paolicchi, A., & Murri, L. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0301-1 · Cited by 55 · see citing works
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches
Castellani, R. J., Zhu, X., Lee, H., Smith, M. A., & Perry, G. L. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10031386 · Cited by 54 · see citing works
Cho, S.-H., Jung, B. H., Lee, S. H., Lee, W., Kong, G., & Chung, B. C. (2006) · Biomedical Chromatography · doi:10.1002/bmc.689 · Cited by 51 · see citing works
Hofer, T., & Perry, G. L. (2016) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2016.06.005 · Cited by 49 · see citing works
Genetic basis of Alzheimer's dementia: role of mtDNA mutations
Grazina, M. M., Pratas, J., Silva, F., Oliveira, S. A., Santana, I. J., & Oliveira, C. R. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00225.x · Cited by 44 · see citing works
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
Castellani, R. J., Nunomura, A., Rolston, R. K., Moreira, P. I., Takeda, A., Perry, G. L., & Smith, M. A. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9050789 · Cited by 43 · see citing works
Ellis, B., Hye, A., & Snowden, S. G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141899 · Cited by 39 · see citing works
Role of RNA Oxidation in Neurodegenerative Diseases
Liu, Z., Chen, X., Li, Z., Ye, W., Ding, H., Li, P., & Aung, L. H. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145022 · Cited by 41 · see citing works
Assays for urinary biomarkers of oxidatively damaged nucleic acids
Weimann, A., Broedbaek, K., Henriksen, T., Stovgaard, E. S., & Poulsen, H. E. (2012) · Free Radical Research · doi:10.3109/10715762.2011.647693 · Cited by 40 · see citing works
Therapeutic Potential of Targeting Mitochondria for Alzheimer’s Disease Treatment
Atlante, A., Amadoro, G., Latina, V., & Valenti, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226742 · Cited by 39 · see citing works
Quantification of RNA damage by reverse transcription polymerase chain reactions
Gong, X., Tao, R., & Li, Z. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.06.025 · Cited by 38 · see citing works
Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice
Um, M. Y., Ahn, J. Y., Kim, S., Kim, M. K., & Ha, T. Y. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1516 · Cited by 36 · see citing works
Xu, Z., Huang, J., Gao, M., Guo, G., Zeng, S., Chen, X., Wang, X., Gong, Z., & Yan, Y. (2020) · GeroScience · doi:10.1007/s11357-020-00209-w · Cited by 33 · see citing works
Biomarkers of Alzheimer’s Disease Risk in Peripheral Tissues; Focus on Buccal Cells
François, M., Leifert, W. R., Martins, R. N., Thomas, P., & Fenech, M. F. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140618103827 · Cited by 32 · see citing works
ApoE Alleles and Tau Markers in Patients with Different Levels of Cognitive Impairment
Manuel Lavados, M., Farias, G. A., Rothhammer, F., Guillón, M., Mujica, M. V., Maccioni, C., & Maccioni, R. B. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.036 · Cited by 32 · see citing works
Homocysteine May Contribute to Pathogenesis of RNA Damage in Brains with Alzheimer’s Disease
Isobe, C., Abe, T., & Terayama, Y. (2009) · Neurodegenerative Diseases · doi:10.1159/000262443 · Cited by 31 · see citing works
Self-citationThe Significance of 8-oxoGsn in Aging-Related Diseases
Zhang, X., & Li, L. (2020) · Aging and Disease · doi:10.14336/ad.2019.1021 · Cited by 27 · see citing works
Tiwari, D., Mittal, N., & Jha, H. C. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100046 · Cited by 27 · see citing works
RNA oxidation: A contributing factor or an epiphenomenon in the process of neurodegeneration
Kong, Q., Shan, X., Chang, Y., Tashiro, H., & Lin, C. G. (2008) · Free Radical Research · doi:10.1080/10715760802311187 · Cited by 27 · see citing works
8-Hydroxyguanine, an Oxidative DNA and RNA Modification
Kasai, H., & Kawai, K. (2016) · RNA technologies · doi:10.1007/978-3-319-34175-0_7 · Cited by 26 · see citing works
Liang, Y., Liu, Q., Du, M., Liu, Z., Yao, S.-M., Zheng, P., Wan, Y., Sun, N. L., Li, Y., Liu, J., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.011 · Cited by 24 · see citing works
Stein, T. D., & Johnson, J. A. (2003) · Reviews in the Neurosciences · doi:10.1515/revneuro.2003.14.4.317 · Cited by 24 · see citing works
Akkaya, Ç., Yavuzer, S., Yavuzer, H., Erkol, G., Bozluolçay, M., & Dinçer, Y. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.04.051 · Cited by 22 · see citing works
New opportunities for antioxidants in amelioration of neurodegenerative diseases
Bhandari, U. R., Danish, S. M., Ahmad, S., Ikram, M., Nadaf, A., Hasan, N., Kesharwani, P., & Ahmad, F. J. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111961 · Cited by 22 · see citing works
Jiang, H.-P., Chu, J.-M., Lan, M., Liu, P., Yang, N., Zheng, F., Yuan, B., & Feng, Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.07.086 · Cited by 21 · see citing works
Christensen, M. R., Poulsen, H. E., Henriksen, T., Weimann, A., Ellervik, C., Lynnerup, N., Rungby, J., & Banner, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.029 · Cited by 21 · see citing works
ZAHER, M. S. M. A. B. M. A. F., & ALY, A. S. (2020) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2020.93997 · Cited by 20 · see citing works
An evaluation of aging measures: from biomarkers to clocks
Wang, Q., Hou, T., Wang, Q., He, J., Wang, L., Si, J., & Chen, S. (2022) · Biogerontology · doi:10.1007/s10522-022-09997-4 · Cited by 18 · see citing works
Vališ, M., Herman, D. P., Váňová, N., Masopust, J., Vyšata, O., Hort, J., Pavelek, Z., Klímová, B., Kuča, K., Misík, J., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00943 · Cited by 19 · see citing works
A multi-omics study to boost continuous bolaform sophorolipid production
Dierickx, S., Maes, K., Roelants, S. L. K. W., Pomian, B., Meulebroek, L. V., Maeseneire, S. L. D., Vanhaecke, L., & Soetaert, W. (2021) · New Biotechnology · doi:10.1016/j.nbt.2021.11.002 · Cited by 17 · see citing works
Abd-Allah, H., Nasr, M., Ahmed-Farid, O. A.-H., El‐Marasy, S. A., Bakeer, R. M., & Ahmed, R. F. (2021) · ACS Omega · doi:10.1021/acsomega.0c05096 · Cited by 16 · see citing works
Biomarkers of Oxidative Stress in Neurodegenerative Diseases
Rukhsana Sultana, A., Cenini, G., & Butterfield, D. A. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch14 · Cited by 16 · see citing works
Li, P., Xu, S., Han, Y., He, H., & Liu, Z. (2023) · Chemical Science · doi:10.1039/d2sc05541d · Cited by 15 · see citing works
Potential Protective Role of Thymoquinone on Experimentally-induced Alzheimer Rats
Zaher, M. F., Bendary, M., El-Aziz, G. S. A., & Ali, A. S. (2019) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2019/v31i630358 · Cited by 15 · see citing works
Estrés oxidativo y enfermedad de Alzheimer
Jiménez, F. J. J., Navarro, H. A., Ayuso‐Peralta, L., & Wadih, T. J. (2006) · Revista de Neurología · doi:10.33588/rn.4207.2005225 · Cited by 14 · see citing works
Um, M. Y., Ahn, J. Y., Kim, M. K., & Ha, T. Y. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0658-0 · Cited by 14 · see citing works
Mao, Y.-H., Xu, L.-N., Weng, Q., Li, X.-Y., Zhao, B., Nie, J.-J., Hu, J.-H., Zhang, L., Chen, Z., Zuo, M.-Z., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4237812 · Cited by 14 · see citing works
Weimann, A., Simonsen, A. H., & Poulsen, H. E. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.12.011 · Cited by 13 · see citing works
Cerebrospinal fluid oxidative stress markers in Alzheimer's disease
Sakakibara, R., & Kawai, T. (2020) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12413 · Cited by 11 · see citing works
Translational approaches to restoring mitochondrial function in Parkinson's disease
Mortiboys, H., Macdonald, R., Payne, T., Sassani, M., Jenkins, T. M., & Bandmann, O. (2017) · FEBS Letters · doi:10.1002/1873-3468.12920 · Cited by 11 · see citing works
Chu, J.-M., Yin, T., Zheng, S.-J., Yang, J., Yuan, B., & Feng, Y. (2017) · Talanta · doi:10.1016/j.talanta.2017.02.062 · Cited by 11 · see citing works
Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer's disease
Arnold, S. E., Hendrix, S. B., Nicodemus‐Johnson, J., Knowlton, N., Williams, V. J., Burns, J. M., Crane, M. K., McManus, A. J., Vaishnavi, S., Arvanitakis, Z., et al. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12487 · Cited by 10 · see citing works
Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study
Mansour, M., Nasr, M., Ahmed-Farid, O. A.-H., & Ahmed, R. F. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00435-3 · Cited by 10 · see citing works
Gonzalez‐Cuyar, L. F., Sonnen, J. A., Montine, K. S., Keene, C. D., & Montine, T. J. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0212-0 · Cited by 10 · see citing works
Dong, J., Huang, A., Wu, T., Chen, Y., & Bie, Z. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c03964 · Cited by 9 · see citing works
The plasma membrane redox system in Alzheimer's disease
Adlard, P. A., & Bush, A. I. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.009 · Cited by 9 · see citing works
Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence
Huang, M., Lai, Y.-C., Lin, S., & Chen, C.-H. (2017) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2017.1344683 · Cited by 9 · see citing works
Oosthoek, M., Lili, A., Almeida, A. M., van Loosbroek, O., van der Geest, R., der Sandt, I. D. G., van Bokhoven, P., Sikkes, S. A. M., Teunissen, C. E., & Vijverberg, E. G. B. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.107 · Cited by 8 · see citing works
Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease
Trombetta, B. A., Wu, C., Kuo, E., de Geus, M. B., Dodge, H. H., Carlyle, B. C., Kivisäkk, P., & Arnold, S. E. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12440 · Cited by 8 · see citing works
Zhai, R., Tai, F., Ding, K., Tan, X., Li, H., Cao, Z., Ge, C., Zheng, X., & Fu, H. (2024) · Stem Cells International · doi:10.1155/2024/7419270 · Cited by 8 · see citing works
Aliev, G. M., Palacios, H. H., & Cacabelos, P. (2012) · Drug Designing Open Access · doi:10.4172/2169-0138.1000103 · Cited by 8 · see citing works
Low Dose Pioglitazone Attenuates Oxidative Damage in Early Alzheimer's Disease by Binding mitoNEET
Hammack, C. D., Perry, G. L., LeBaron, R. G., Villareal, G., & Phelix, C. F. (2015) · International Journal of Knowledge Discovery in Bioinformatics · doi:10.4018/ijkdb.2015010103 · Cited by 6 · see citing works
A novel method for ionizing radiation-induced RNA damage detection by poly(A)-tailing RT-PCR
Tie, Y., Hu, Z., GuiXiang, L., Fu, H., Xing, R., Zhu, J., Sun, Z., & Zheng, X. (2011) · Chinese Science Bulletin · doi:10.1007/s11434-011-4721-7 · Cited by 6 · see citing works
- Authors
- Abe, T., Tohgi, H., Isobe, C., Murata, T., & Sato, C.
- Affiliations
- Iwate Medical University (JP)
- Corresponding author
- Tohgi, Hideo
- ORCID
- Abe, Takashi
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2002-10-18
- Volume
- 70
- Issue
- 3
- Pages
- 447-450
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2059334739
- Cited by
- 124
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- 8-hydroxyguanosine, Alzheimer's disease, cerebrospinal fluid biomarkers, oxidative RNA damage, oxidative stress, serum biomarkers, disease progression, cognitive decline
- MeSH terms
- Aged, Alzheimer Disease, Brain, Female, Guanosine, Humans, Male, Middle Aged, Neurons, RNA, Up-Regulation, Oxidative Stress
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