Cited by 185Regulation of Appetite and ObesityNerve injury and regenerationGenetics, Aging, and Longevity in Model Organisms

Brain‐derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health

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Rothman, Sarah M., Griffioen, Kathleen J., Wan, Ruiqian, Mattson, Mark P.·2012·Annals of the New York Academy of Sciences

Abstract

Overweight sedentary individuals are at increased risk for cardiovascular disease, diabetes, and some neurological disorders. Beneficial effects of dietary energy restriction (DER) and exercise on brain structural plasticity and behaviors have been demonstrated in animal models of aging and acute (stroke and trauma) and chronic (Alzheimer's and Parkinson's diseases) neurological disorders. The findings described later, and evolutionary considerations, suggest brain‐derived neurotrophic factor (BDNF) plays a critical role in the integration and optimization of behavioral and metabolic responses to environments with limited energy resources and intense competition. In particular, BDNF signaling mediates adaptive responses of the central, autonomic, and peripheral nervous systems from exercise and DER. In the hypothalamus, BDNF inhibits food intake and increases energy expenditure. By promoting synaptic plasticity and neurogenesis in the hippocampus, BDNF mediates exercise‐ and DER‐induced improvements in cognitive function and neuroprotection. DER improves cardiovascular stress adaptation by a mechanism involving enhancement of brainstem cholinergic activity. Collectively, findings reviewed in this paper provide a rationale for targeting BDNF signaling for novel therapeutic interventions in a range of metabolic and neurological disorders.

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Crossref · 10.1111/j.1749-6632.2012.06525.x

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  • In the hippocampus, BDNF promotes the production and survival of new neurons from stem cells and the integration of new neurons into existing neuronal circuits.

    “In the hippocampus, BDNF promotes the production and survival of new neurons from stem cells and the integration of new neurons into existing neuronal circuits [141], reviewed in [160].”

    From The neuropathology of sport (2014) · cites this paper as [160]

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Authors
Rothman, S. M., Griffioen, K. J., Wan, R., & Mattson, M. P.
Affiliations
National Institutes of Health (US)
Corresponding author
Rothman, Sarah M.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2012-04-30
Volume
1264
Issue
1
Pages
49-63
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2135826654
Cited by
185
References
134
Citations by year
2026: 9 · 2025: 11 · 2024: 12 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 13 · 2018: 17 · 2017: 19 · 2016: 14 · 2015: 20 · 2014: 14 · 2013: 11 · 2012: 4
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (Z99 AG999999)
  • National Institute on Aging
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
brain-derived neurotrophic factor, energy metabolism, cardiovascular health, hypocaloric diet, physical activity, hypothalamus, dietary intake, energy expenditure, synaptic plasticity, hippocampal neurogenesis, cognitive function, neuroprotection, cholinergic activity, brainstem, obesity, diabetes mellitus, neurological disorders, BDNF signaling
MeSH terms
Animals, Autonomic Nervous System, Cardiovascular Diseases, Central Nervous System, Cognition, Eating, Energy Metabolism, Hippocampus, Humans, Hypothalamus, Neuronal Plasticity, Obesity, Exercise, Brain-Derived Neurotrophic Factor, Caloric Restriction, Mice

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