Intracerebroventricular passive immunization with anti‐oligoAβ antibody in TgCRND8
Abstract
Based on the central dogma of beta-amyloid (Abeta) as a key seeding event in the pathogenesis of Alzheimer disease (AD), immunoneutralization strategies have been actively pursued both in AD and in models of AD as a potential means for treating AD. Both active and passive immunizations targeted at fibrillar Abeta successfully remove cerebral plaque load and attenuate Abeta-induced toxicity. Consistently with this, intracerebroventricular (ICV) passive immunization established in our laboratory using antibody against fibrillar Abeta (anti-fAbeta) reduced cerebral plaque load and reversed early synaptic deficits at pre/early plaque stage when there is an abundance of soluble dimeric/oligomeric Abeta but sparse fibrillar Abeta, indicating that anti-fAbeta-mediated partial neutralization of toxic oligomeric Abeta species might have reduced early synaptotoxicity. In the previous investigation, we found that immunoneutralization with anti-fAbeta transiently reduced cerebral Abeta and associated toxicity. The current investigation tested whether ICV im munization using antibody to conformationally changed oligomeric Abeta (anti-oligoAbeta) will overcome the transient restorative nature of anti-fAbeta and produce persistent, long-lasting preventive effects. Because oligomeric Abeta is strongly correlated with synaptotoxicity, we investigated whether immunoneutralization of oligomeric Abeta will reverse synaptic deficits by analyzing presynaptic molecular marker (SNAP-25) profile within hippocampal dendritic fields, where SNAP-25 is abundantly expressed. Results show that, in contrast to ICV anti-fAbeta antibody, ICV anti-oligoAbeta antibody significantly prevented cerebral Abeta build and almost completely restored SNAP-25 immunoreaction up to 8 weeks postinjection in TgCRND8 brain. Results show that ICV passive immunization with anti-oligoAbeta antibody might be an improved ICV immunization strategy for preventing permanent structural damage in AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Synapse deterioration in transgenic mice is prevented by ICV injections of oligomer-specific antibodies.
“Synapse deterioration in tg-mice is prevented by ICV injections of oligomer-specific antibodies (Chauhan, 2007; Oddo et al., 2006).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Chauhan, 2007
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064 · see citing works
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530 · see citing works
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works
Chishti, M. A., Yang, D.-S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100710200 · Cited by 955 · see citing works
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-04.2004 · Cited by 954 · see citing works
Kayed, R., Sokolov, Y., Edmonds, B. W., McIntire, T. M., Milton, S. C. F., Hall, J. E., & Glabe, C. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400260200 · Cited by 903 · see citing works
Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 669 · see citing works
Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains
Kuo, Y.-M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J., & Roher, A. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4077 · Cited by 618 · see citing works
Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets
Klein, W. L. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00050-5 · Cited by 541 · see citing works
Amyloid-β oligomers: their production, toxicity and therapeutic inhibition
Walsh, D. M., Klyubin, I. V., Fadeeva, J. V., Rowan, M. J., & Selkoe, D. J. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300552 · Cited by 507 · see citing works
Roher, A. E., Chaney, M. O., Kuo, Y., Webster, S. D., Stine, W. B., Haverkamp, L. J., Woods, A. S., Cotter, R. J., Tuohy, J. M., Krafft, G. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20631 · Cited by 494 · see citing works
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1234 · Cited by 489 · see citing works
Kawarabayashi, T., Shoji, M., Younkin, L. H., Lin, W.-L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H., & Younkin, S. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5543-03.2004 · Cited by 365 · see citing works
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
Glabe, C. G., & Kayed, R. (2006) · Neurology · doi:10.1212/01.wnl.0000192103.24796.42 · Cited by 364 · see citing works
Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348 · see citing works
Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
Teller, J. K., Russo, C., DeBusk, L. M., Angelini, G., Zaccheo, D., Dagna-Bricarelli, F., Scartezzini, P., Bertolini, S., Mann, D. M. A., Tabaton, M., et al. (1996) · Nature Medicine · doi:10.1038/nm0196-93 · Cited by 326 · see citing works
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
Coleman, P., Federoff, H., & Kurlan, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140626.48118.0a · Cited by 314 · see citing works
Age‐dependent cognitive decline in the APP23 model precedes amyloid deposition
Dam, D. V., D’Hooge, R., Staufenbiel, M., Ginneken, C. J. V., Meir, F. V., & Deyn, P. P. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02444.x · Cited by 297 · see citing works
Wogulis, M., Wright, S., Cunningham, D., Chilcote, T., Powell, K., & Rydel, R. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2381-04.2005 · Cited by 233 · see citing works
Toxicity of Amyloid β Peptide: Tales of Calcium, Mitochondria, and Oxidative Stress
Canevari, L., Abramov, A. Y., & Duchen, M. R. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014834.06405.af · Cited by 221 · see citing works
Structural studies of soluble oligomers of the alzheimer β-amyloid peptide
Huang, T. H. J., Dun-Sheng, Y., Plaskos, N. P., Go, S., Yip, C. M., Fraser, P. E., & Chakrabartty, A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3559 · Cited by 213 · see citing works
Adult-derived neural precursors transplanted into multiple regions in the adult brain
Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199912)46:6 · Cited by 204 · see citing works
Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease
El‐Agnaf, O. M. A., Mahil, D. S., PATEL, B. P., & Austen, B. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3051 · Cited by 196 · see citing works
β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?
Auld, D. S., Kar, S., & Quirion, R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01144-2 · Cited by 192 · see citing works
Buttini, M., Yu, G.-Q., Shockley, K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, F. M., & Mucke, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10539.2002 · Cited by 183 · cited 4× · see citing works
“of studies, including our own, have substantiated this fact in the animal models of AD showing destructive potential of oligomeric Ab involved in plaque-independent synaptic degeneration (Mucke et al., 2000; Chauhan and Siegel, 2002; Buttini et al., 2002; Van Dam et al., 2003; Palop et al., 2005), impairment in learni…”
BackgroundResultInfluentialConformation-dependent antibodies target diseases of protein misfolding
Glabe, C. C. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.08.009 · Cited by 154 · see citing works
Palop, J. J., Chin, J., Bien‐Ly, N., Massaro, C. M., Yeung, B. Z., Yu, G.-Q., & Mucke, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2829-05.2005 · Cited by 144 · see citing works
Watson, D., Castaño, E., Kokjohn, T. A., Kuo, Y., Lyubchenko, Y. L., Pinsky, D. J., Connolly, E. S., Esh, C. L., Luehrs, D. C., Stine, W. B., et al. (2005) · Neurological Research · doi:10.1179/016164105x49436 · Cited by 129 · see citing works
Ma, Q., Lim, G. P., Harris‐White, M. E., Yang, F., Ambegaokar, S. S., Ubeda, O. J., Glabe, C. G., Teter, B., Frautschy, S. A., & Cole, G. M. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20734 · Cited by 126 · see citing works
Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
Pereira, C., Agostinho, P. M., Moreira, P. I., Cardoso, S. M., & Oliveira, C. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054546117 · Cited by 122 · see citing works
Mechanisms of ß-Amyloid Neurotoxicity: Perspectives of Pharmacotherapy
Harkany, T., Ábrahám, I. M., Kónya, C., Nyakas, C. J., Zarándi, M., Penke, B., & Luiten, P. G. M. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.4.329 · Cited by 122 · see citing works
Chapter 29 Neuropathological changes in Alzheimer disease
Terry, R. D. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)61964-0 · Cited by 120 · see citing works
Chauhan, N. B., Siegel, G. J., & Feinstein, D. L. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000042217.90204.8d · Cited by 77 · see citing works
Chang, K., & Suh, Y. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cr0050014 · Cited by 71 · see citing works
Chauhan, N. B., & Siegel, G. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10286 · Cited by 53 · see citing works
Intracerebroventricular passive immunization with anti‐Aβ antibody in Tg2576
Chauhan, N. B., & Siegel, G. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10721 · Cited by 45 · see citing works
Efficacy of anti-Aβ antibody isotypes used for intracerebroventricular immunization in TgCRND8
Chauhan, N. B., & Siegel, G. J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.090 · Cited by 37 · see citing works
Effect of PPF and ALCAR on the Induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain
Chauhan, N. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00006-8 · Cited by 37 · see citing works
Chauhan, N. B., Siegel, G. J., & Lichtor, T. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1215 · Cited by 34 · see citing works
Chauhan, N. B., Siegel, G. J., & Lichtor, T. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20298 · Cited by 24 · see citing works
Intracerebroventricular passive immunization in transgenic mouse models of Alzheimer’s disease
Chauhan, N. B., & Siegel, G. J. (2004) · Expert Review of Vaccines · doi:10.1586/14760584.3.6.717 · Cited by 15 · see citing works
Memory loss independent of plaque formation in Alzheimer's model
Love, R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06930-6 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Estes, D. M., Barrett, A. D. T., Dineley, K. T., Jackson, G. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3192-13.2014 · Cited by 278 · see citing works
“…phenotypes and specifically clears tau oligomers in P301L mice Injection of anti-amyloid antibodies in AD animal models via intracerebroventricular injection has been performed in a few well executed studies (Chauhan and Siegel, 2003; Oddo et al., 2004; Chauhan, 2007; Thakker et al., 2009).”
MethodKlein, W. L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129039 · Cited by 141 · see citing works
ADDLs and the signaling web that leads to Alzheimer’s disease
Krafft, G. A., & Klein, W. L. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.07.012 · Cited by 111 · see citing works
Head, E., Pop, V., Vasilevko, V., Hill, M., Saing, T., Sarsoza, F. M., Nistor, M., Christie, L., Milton, S. C. F., Glabe, C. G., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0208-08.2008 · Cited by 106 · see citing works
Modarres, H. P., Janmaleki, M., Novin, M., Saliba, J., Moussa, F. E. H., Charan, M. R., Seyfoori, A., SadAbadi, H., Vandal, M., Nguyen, M. D., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.024 · Cited by 73 · see citing works
Xiao, C., Davis, F., Chauhan, B. C., Viola, K. L., Lacor, P. N., Velasco, P. T., Klein, W. L., & Chauhan, N. B. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122419 · Cited by 59 · see citing works
Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury
Chauhan, N. B., & Gatto, R. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.010 · Cited by 40 · see citing works
Aβ peptide conformation determines uptake and interleukin-1α expression by primary microglial cells
Parvathy, S., Rajadas, J., Ryan, H. S., Vaziri, S., Anderson, L., & Murphy, G. M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.011 · Cited by 39 · see citing works
Targeting Beta-Amyloid at the CSF: A New Therapeutic Strategy in Alzheimer’s Disease
Menéndez‐González, M., Padilla-Zambrano, H., Alvarez, G., Capetillo‐Zarate, E., Tomás‐Zapico, C., & Costa, A. D. D. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00100 · Cited by 36 · see citing works
Immunotherapy as treatment for Alzheimer’s disease
Hawkes, C. A., & McLaurin, J. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.11.1535 · Cited by 33 · see citing works
Lambert, M., Velasco, P., Viola, K., & Klein, W. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601876 · Cited by 29 · see citing works
Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27 · see citing works
Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice
Carrera, I., Etcheverrı́a, I., Fernández‐Novoa, L., Lombardi, V., Cacabelos, R., & Vigo, C. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/376138 · Cited by 27 · see citing works
Preventive immunization of aged and juvenile non-human primates to beta-amyloid
Kofler, J., Lopresti, B. J., Janssen, C., Trichel, A. M., Masliah, E., Finn, O. J., Salter, R. D., MURDOCH, G. H., Mathis, C. A., & Wiley, C. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-84 · Cited by 25 · see citing works
Tucker, S. M. F., Borchelt, D., & Troncoso, J. C. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31815f38d2 · Cited by 22 · see citing works
Li, H., Wang, X., Yu, H., Zhu, J., Jin, H., Wang, A., & Yang, Z. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171030142108 · Cited by 20 · see citing works
Wang, J., Li, N., Ma, J., Gu, Z., Yu, L., Fu, X., Liu, X., & Wang, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.028 · Cited by 16 · see citing works
DNA Vaccine Therapy for Alzheimer's Disease: Present Status and Future Direction
Okura, Y., & Matsumoto, Y. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0638 · Cited by 17 · see citing works
Clos, A. L., Lasagna‐Reeves, C. A., Wagner, R. F., Kelly, B. C., Jackson, G. R., & Kayed, R. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01121.x · Cited by 14 · see citing works
Chauhan, N. B., Davis, F., & Xiao, C. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.08.009 · Cited by 12 · see citing works
Cheng, L., Zhang, J., Li, X., Li, Y., Pan, Y., Chen, X., Gao, T., Qiao, J., & Qi, J. (2016) · Hippocampus · doi:10.1002/hipo.22676 · Cited by 11 · see citing works
Alzheimers Disease: Review of Emerging Treatment Role for Intravenous Immunoglobulins
Kayed, R., Jackson, G. R., Estes, D. M., & Barrett, A. D. T. (2011) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s5018 · Cited by 9 · see citing works
Ayhan, B., & Yıldırım, M. E. (2026) · Cytotechnology · doi:10.1007/s10616-026-00915-x
- Authors
- Chauhan, N. B.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Chauhan, Neelima B.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2006-11-03
- Volume
- 85
- Issue
- 2
- Pages
- 451-463
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1978554758
- Cited by
- 24
- References
- 56
- Citations by year
- 2026: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS044538, R21NS044538)
- National Center for Complementary and Integrative Health (R21AT001812, AT001812)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid-beta oligomers, immunoneutralization, synaptotoxicity, SNAP-25, presynaptic markers, hippocampus, amyloid plaques
- MeSH terms
- Alzheimer Disease, Animals, Antibodies, Enzyme-Linked Immunosorbent Assay, Hippocampus, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Injections, Intraventricular, Mice, Inbred C57BL, Mice, Transgenic, Amyloid beta-Peptides, Alzheimer Vaccines, Synaptosomal-Associated Protein 25, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review