Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Alzheimer's disease: the amyloid cascade hypothesis

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

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Amyloid pores from pathogenic mutations

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques

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Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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Amyloid β-Protein Fibrillogenesis

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Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

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Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

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In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis

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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

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Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

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Detection of a Biomarker for Alzheimer's Disease from Synthetic and Clinical Samples Using a Nanoscale Optical Biosensor

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer’s disease

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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

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Structural Classification of Toxic Amyloid Oligomers

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Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

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Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

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Amyloid diseases: Abnormal protein aggregation in neurodegeneration

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Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

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Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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Globular amyloid β‐peptide ₁₋₄₂ oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease

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Kinetic theory of fibrillogenesis of amyloid β-protein

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Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

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Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

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Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

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Reversible memory loss in a mouse transgenic model of Alzheimer’s disease

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Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology

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The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β‐amyloid

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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

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Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies

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Amyloid β-Protein: Monomer Structure and Early Aggregation States of Aβ42 and Its Pro 19 Alloform

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Conformational Abs recognizing a generic amyloid fibril epitope

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Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

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Intravenous immunoglobulins containing antibodies against -amyloid for the treatment of Alzheimer's disease

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Monoclonal antibodies that target pathological assemblies of Aβ

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Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310 · see citing works

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease

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Sensitive ELISA detection of amyloid‐β protofibrils in biological samples

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Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis

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Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.

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A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ

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Targeting Amyloid-β Peptide (Aβ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Aβ Precursor Protein (APP) Transgenic Mice

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Active and passive immunotherapy for neurodegenerative disorders

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The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina

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Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules

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Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

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Alzheimer's Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human Primate, the Caribbean Vervet

Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63296-8 · Cited by 230 · see citing works

Neurotoxic protein oligomers — what you see is not always what you get

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Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

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Adult-derived neural precursors transplanted into multiple regions in the adult brain

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Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

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Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Aβ oligomerization

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High Levels of Circulating Aβ42 Are Sequestered by Plasma Proteins in Alzheimer's Disease

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The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

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Morphological Characterization of Thioflavin-S-Positive Amyloid Plaques in Transgenic Alzheimer Mice and Effect of Passive Aβ Immunotherapy on Their Clearance

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