The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
VEGF‐overexpressing transgenic mice show enhanced post‐ischemic neurogenesis and neuromigration
Abstract
New neurons are generated continuously in the subventricular zone and dentate gyrus of the adult brain. Neuropathologic processes, including cerebral ischemia, can enhance neurogenesis, as can growth factors and other physiologic stimuli. Vascular endothelial growth factor (VEGF) is an angiogenic and neuroprotective growth factor that can promote neurogenesis, but it is unknown whether VEGF can enhance migration of newborn neurons toward sites of ischemic injury, where they might be able to replace neurons that undergo ischemic death. In the present study we produced permanent focal cerebral ischemia in transgenic (Tg) mice that overexpress VEGF. Cell proliferation and neurogenesis were assessed with bromodeoxyuridine (Brdu) labeling and immunostaining for cell type‐specific markers. In VEGF‐Tg mice, brains examined 7–28 days after cerebral ischemia showed markedly increased subventricular zone (SVZ) neurogenesis, chains of neuroblasts extending from the SVZ to the peri‐infarct cortex, and an increase in the number of newly generated cortical neurons at 14–28 days after ischemia. In concert with these effects, VEGF overexpression reduced infarct volume and improved postischemic motor function. These findings provide evidence that VEGF increases SVZ neurogenesis and neuromigration, consistent with a possible role in repair. Our data suggest that in addition to its neuroprotective effects, which are associated with improved outcome in the acute phase after cerebral ischemia, VEGF enhances postischemic neurogenesis, which could provide a therapeutic target for more chronic brain repair. © 2007 Wiley‐Liss, Inc.
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Citations
Cites
Neuronal replacement from endogenous precursors in the adult brain after stroke
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NeuN, a neuronal specific nuclear protein in vertebratesxs
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Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
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Self-citationVEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
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“…2005), or transgenic overexpression (Wang et al., 2005; this study), suggests that direct delivery is in some ways preferable to systemic administration, which may be accompanied by brain edema from increased vascular permeability and a poorer outcome (van Bruggen et al., 1999; Zhang et al., 2000).”
BackgroundVEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189
Self-citationCoordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
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Self-citationSun, Y., Jin, K., Childs, J. T., Xie, L., Mao, X. O., & Greenberg, D. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.016 · Cited by 178
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Cited by
Role and Therapeutic Potential of VEGF in the Nervous System
Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009) · Physiological Reviews · doi:10.1152/physrev.00031.2008 · Cited by 448
Neurovascular signalling defects in neurodegeneration
Zacchigna, S., Lambrechts, D., & Carmeliet, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2336 · Cited by 345
Angiogenesis and neuronal remodeling after ischemic stroke
Kanazawa, M., Hatakeyama, M., & Ninomiya, I. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.264442 · Cited by 328
Diverse roles for VEGF-A in the nervous system
Mackenzie, F., & Ruhrberg, C. (2012) · Development · doi:10.1242/dev.072348 · Cited by 294
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
Carmeliet, P., & de Almodovar, C. R. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1283-7 · Cited by 173
Metadata
- Authors
- Wang, Y., Jin, K., Mao, X. O., Xie, L., Banwait, S., Marti, H. H., & Greenberg, D. A.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2007-01-22
- Volume
- 85
- Issue
- 4
- Pages
- 740-747
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1966389744
- Cited by
- 190
- References
- 10
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
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