Diverse roles for VEGF-A in the nervous system
Abstract
Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of neuronal functions, both in vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance. Recent studies have employed mouse models to distinguish the direct effects of VEGF on neurons from its indirect, vessel-mediated effects. Ultimately, refining our knowledge of VEGF signalling pathways in neurons should help us to understand how the current use of therapeutics targeting the VEGF pathway in cancer and eye disease might be expanded to promote neuronal health and nerve repair.
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VEGF stimulates cerebral angiogenesis and neurogenesis.
“VEGF stimulates cerebral angiogenesis and neurogenesis (MacKenzie and Ruhrberg, 2012).”
From Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes (2013) · cites this paper as MacKenzie and Ruhrberg, 2012
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- Authors
- Mackenzie, F., & Ruhrberg, C.
- Affiliations
- UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-04-15
- Volume
- 139
- Issue
- 8
- Pages
- 1371-1380
- ISSN
- 1477-9129
- 0950-1991
- Cited by
- 266
- References
- 12
- Language
- en
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