Cited by 116Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Transcription factor Sp1 dysregulation in Alzheimer's disease

Citron, Bruce A., Dennis, John S., Zeitlin, Ross S., Echeverria, Valentina·2008·Journal of Neuroscience Research

Abstract

Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 may be involved insofar as it can regulate the expression of several AD‐related proteins, including amyloid precursor protein (APP) and tau. Sp1 could itself be regulated by inflammatory and other factors associated with AD, such as interleukin‐1β. We measured an almost threefold elevation in the number of mRNA molecules of this cytokine in the AD frontal cortex. Sp1 mRNA was found to be up‐regulated in these AD brains (along with Sp1‐regulated COX‐2), and the Sp1 increase was also seen at the protein level by Western immunoblotting. To determine whether this would also occur in transgenic mice developing AD pathology, we examined the expression of Sp1 in the cortex and hippocampus and observed higher levels of Sp1 mRNA and protein. These results indicate that elements of regulatory pathways involving transcription factor Sp1 may be useful targets for therapeutic intervention to prevent or reverse AD. © 2008 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/jnr.21695

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • SP1, a transcription factor that regulates the expression of several amyloid and tau-related genes, has been found to be abnormally expressed in the frontal cortex and hippocampus of patients with AD.

    “It is noteworthy that SP1, a transcription factor that regulates the expression of several amyloid and tau-related genes,47 has been found to be abnormally expressed in the frontal cortex and hippocampus of patients with AD.48”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Citron, B. A., Dennis, J. S., Zeitlin, R. S., & Echeverria, V.
Affiliations
  • University of South Florida (US)
  • Bay Pines VA Healthcare System (US)
Corresponding author
Citron, Bruce A.
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2008-04-30
Volume
86
Issue
11
Pages
2499-2504
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W1999973557
Cited by
116
References
41
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 1
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Cancer Research Institute
  • H. Lee Moffitt Cancer Center and Research Institute
  • University of South Florida
  • Moffitt Cancer Center
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Sp1, Alzheimer's disease, amyloid precursor protein, tau protein, IL-1β, cyclooxygenase-2, gene expression dysregulation, frontal cortex, hippocampus, transgenic mouse model, neuroinflammation, therapeutic target
MeSH terms
Aged, Alzheimer Disease, Animals, Brain, Humans, Mice, Transgenic, RNA, Messenger, Blotting, Western, Up-Regulation, Gene Expression, Sp1 Transcription Factor, Reverse Transcriptase Polymerase Chain Reaction, Mice, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review