Oxidative stress disrupts oligodendrocyte maturation

French, Heather Morein; Reid, Mary; Mamontov, Polina; Simmons, Rebecca A.; Grinspan, Judith B.

doi:10.1002/jnr.22139

Cited by 246Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyRedox biology and oxidative stress

Oxidative stress disrupts oligodendrocyte maturation

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French, Heather Morein, Reid, Mary, Mamontov, Polina, Simmons, Rebecca A., Grinspan, Judith B.·2009·Journal of Neuroscience Research

DOI 10.1002/jnr.22139PMC PMC3138415

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Abstract

Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature, myelinating oligodendrocytes. Oligodendrocytes undergo a well‐characterized lineage progression from neural stem cell to mature oligodendrocyte. Oligodendrocyte precursors have increased susceptibility to oxidative and free radical‐mediated injury compared with mature oligodendrocytes as a result of lower levels of antioxidant enzymes and free radical scavengers. In this study, we show that oxidative stress disrupts oligodendrocyte differentiation by two mechanisms. First, oxidizing agents decrease the expression of key genes that promote oligodendrocyte differentiation from neural stem cells and increase the expression of genes known to inhibit differentiation. Second, global histone acetylation persists under conditions of oxidative stress, further contributing to the prevention of oligodendrocyte differentiation. Both of these mechanisms result in the arrest of oligodendrocyte differentiation without an increase in cell death. © 2009 Wiley‐Liss, Inc.

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Oligodendrocyte progenitor cells in late development are particularly susceptible to injury under chronic hypoxia and oxidative stress in ischemic white matter.
“First, OPC in the late stage of development are particularly susceptible to injury in conditions of chronic hypoxia and oxidative stress existing in the ischemic white matter (Back et al., 2011; 2002; Fernando et al., 2006; French et al., 2009).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as French et al., 2009
The intracellular redox state controls the proliferation and differentiation of oligodendrocytes, and low glutathione levels affect oligodendrocyte maturation.
“Furthermore, the intracellular redox state controls the proliferation and differentiation of oligodendrocytes (Li et al., 2007; Smith et al., 2000; Do et al., 2012), and low GSH levels affect oligodendrocyte maturation (French et al., 2009).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as French et al., 2009

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Authors: French, H. M., Reid, M., Mamontov, P., Simmons, R. A., & Grinspan, J. B.
Affiliations: Children's Hospital of Philadelphia (US)
Corresponding author: Simmons, Rebecca A.
Grinspan, Judith B.
ORCID: Simmons, Rebecca A.
Grinspan, Judith B.
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2009-05-28
Volume: 87
Issue: 14
Pages: 3076-3087
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.22139
PMC: PMC3138415
OpenAlex: W2015778757
Cited by: 246
References: 78
Citations by year: 2026: 25 · 2025: 18 · 2024: 20 · 2023: 18 · 2022: 22 · 2021: 24 · 2020: 18 · 2019: 16 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 10 · 2014: 15 · 2013: 7 · 2012: 5
FWCI: 1.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Multiple Sclerosis Society
National Institutes of Health
National Institute on Aging (AG20898, R01AG020898)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, oligodendrocyte maturation, oligodendrocyte differentiation, periventricular white matter injury, preterm birth, hypomyelination, histone acetylation, neural stem cells, oligodendrocyte precursor cells, antioxidant enzymes, gene expression regulation
MeSH terms: Acetylation, Animals, Cell Differentiation, Cells, Cultured, Electrophoresis, Polyacrylamide Gel, Histones, Immunohistochemistry, Oligodendroglia, Blotting, Western, Gene Expression, Rats, Sprague-Dawley, Apoptosis, Oxidative Stress, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, In Situ Nick-End Labeling, Rats

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Oxidative stress disrupts oligodendrocyte maturation

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