The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis
Abstract
The changes in the tensile mechanical properties and biochemical composition of the superficial zone of articular cartilage were examined in a canine model of early osteoarthritis generated by transection of the anterior cruciate ligament. Sixteen weeks following ligament transection, the tensile stiffness of the articular cartilage was decreased by 44% and the ion‐induced stress relaxation of the tissue was increased by 57% compared with the contralateral control. Biochemical analyses indicated that the water content of the experimental tissue was increased by 13%, which was reflected as an apparent 37% decrease in the proteoglycan content and a 36% decrease in the collagen content (expressed per wet weight). The hydroxypyridinium crosslink density was decreased in the experimental tissue by 11%. A significant negative correlation was found between the ion‐induced stress relaxation and the hydroxypyridinium crosslink density in both control tissue (R = −0.56) and experimental tissue (R = −0.70). No correlation was noted between the tensile stiffness and the biochemical composition of the tissue. These results suggest that, in the superficial zone of articular cartilage, the structure of the tissue may play a more important role than the composition in the determination of its mechanical properties. A major event observed in the model of early osteoarthritis appears to be the disruption and remodeling of the collagen network in the superficial zone of the articular cartilage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Determination of hydroxyproline
Stegemann, H., & Stalder, K. (1967) · Clinica Chimica Acta · doi:10.1016/0009-8981(67)90167-2 · Cited by 1,570
A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures
Farndale, R. W., Sayers, C. A., & Barrett, A. J. (1982) · Connective Tissue Research · doi:10.3109/03008208209160269 · Cited by 1,347
A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage
Lai, W. M., Hou, J. S., & Mow, V. C. (1991) · Journal of Biomechanical Engineering · doi:10.1115/1.2894880 · Cited by 1,127
Self-citationCartilage and diarthrodial joints as paradigms for hierarchical materials and structures
Mow, V. C., Ratcliffe, A., & Robin Poole, A. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90001-5 · Cited by 956
Self-citationQuantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography
Eyre, D. R., Koob, T. J., & Van Ness, K. P. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90101-5 · Cited by 658
Structure and biology of cartilage and bone matrix noncollagenous macromolecules
Heinegård, D., & Oldberg, Å. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.9.2663581 · Cited by 565
Wainwright, D. (1974) · Injury · doi:10.1016/0020-1383(74)90182-x · Cited by 511
Akizuki, S., Mow, V. C., Müller, F., Pita, J. C., Howell, D. S., & Manicourt, D. H. (1986) · Journal of Orthopaedic Research · doi:10.1002/jor.1100040401 · Cited by 504
Self-citationExperimentally-induced osteoarthritis in the dog.
Pond, M. J., & Nuki, G. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.4.387 · Cited by 477
KEMPSON, G., MUIR, H., POLLARD, C., & TUKE, M. (1973) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(73)90093-7 · Cited by 453
Cited by
Detection of changes in cartilage water content using MRI T2-mapping
Liess, C., Lüsse, S., Karger, N., Heller, M., & Glüer, C.-C. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2002.0847 · Cited by 366
GUILAK, F., ALEXOPOULOS, L. G., UPTON, M. L., YOUN, I., CHOI, J. B., CAO, L., SETTON, L. A., & HAIDER, M. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.011 · Cited by 357
Self-citationAutophagy and cartilage homeostasis mechanisms in joint health, aging and OA
Lotz, M. K., & Caramés, B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.109 · Cited by 314
Lynch, H. A., Johannessen, W., Wu, J. P., Jawa, A., & Elliott, D. M. (2003) · Journal of Biomechanical Engineering · doi:10.1115/1.1614819 · Cited by 272
Liebl, H., Joseph, G., Nevitt, M. C., Singh, N., Heilmeier, U., Subburaj, K., Jungmann, P. M., McCulloch, C. E., Lynch, J. A., Lane, N. E., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204157 · Cited by 149
Self-citation
Metadata
- Authors
- Guilak, F., Ratcliffe, A., Lane, N., Rosenwasser, M. P., & Mow, V. C.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 1994-07
- Volume
- 12
- Issue
- 4
- Pages
- 474-484
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W1982934551
- Cited by
- 335
- References
- 23
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. https://app.cochat.ai/papers/10.1002/jor.1100120404
- The paper
- Guilak, F., Ratcliffe, A., Lane, N., Rosenwasser, M. P., & Mow, V. C. (1994). Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.1100120404
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
