The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Biomechanical consequences of an isolated overload on the human vertebral body
Abstract
The biomechanical consequences of an isolated overload to the vertebral body may play a role in the etiology of vertebral fracture. In this context, we quantified residual strains and reductions in stiffness and ultimate load when vertebral bodies were loaded to various levels beyond the elastic regimen and related these properties to the externally applied strain and bone density. Twenty‐three vertebral bodies (T11‐L4, from 23 cadavers aged 20–90 years) were loaded once in compression to a randomized nominal strain level between 0.37 and 4.5%, unloaded, and then reloaded to 10% strain. Residual strains of up to 1.36% developed on unloading and depended on the applied strain (r 2 = 0.85) but not on density (p = 0.25). Percentage reductions in stiffness and ultimate load of up to 83.7 and 52.5%, respectively, depended on both applied strain (r 2 = 0.90 and r 2 = 0.32, respectively) and density (r 2 = 0.23 and r 2 = 0.22, respectively). Development of residual strains is indicative of permanent deformations, whereas percentage reductions in stiffness are direct measures of effective mechanical damage. These results therefore demonstrate that substantial mechanical damage—which is not visible from radiographs—can develop in the vertebral body after isolated overloads, as well as subtle but significant permanent deformations. This behavior is similar to that observed previously for cylindrical cores of trabecular bone. Taken together, these findings indicate that the damage behavior of the lumbar and lower thoracic vertebral body is dominated by the trabecular bone and may be an important factor in the etiology of vertebral fracture.
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“These effects occur in trabecular samples and in the entire vertebral body (81)”
From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [81]
Citations
Cites
EPIDEMIOLOGY OF VERTEBRAL FRACTURES IN WOMEN
Melton, L. J., Kan, S. H., Frye, M. A., Wahner, H. W., O’Fallon, W. M., & Riggs, B. L. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115204 · Cited by 922
In vivo measurement of human tibial strains during vigorous activity
Burr, D. B., Milgrom, C., Fyhrie, D. P., Forwood, M. R., Nyska, M., Finestone, A. S., Hoshaw, S. J., Saiag, E., & Simkin, A. (1996) · Bone · doi:10.1016/8756-3282(96)00028-2 · Cited by 714
Classification of vertebral fractures
Eastell, R., Cedel, S. L., Wahner, H. W., Riggs, B. L., & Melton, L. J. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060302 · Cited by 610
Epidemiology of Vertebral Fractures
Schousboe, J. T. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.08.004 · Cited by 459
Prediction of vertebral body compressive fracture using quantitative computed tomography.
McBroom, R., Hayes, W. C., Edwards, W. T., Goldberg, R. P., & White, A. A. (1985) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198567080-00010 · Cited by 430
Campbell's Operative Orthopaedics
Cooper, R. R. (1992) · JAMA · doi:10.1001/jama.1992.03490130167054 · Cited by 355
Continuum Damage Mechanics Theory and Application
Krajcinovic, D., & Lemaitre, J. (1987) · Springer eBooks · doi:10.1007/978-3-7091-2806-0 · Cited by 293
The Bone Mineral Content and Ultimate Compressive Strength of Lumbar Vertebrae
HANSSON, T. H., ROOS, B., & NACHEMSON, A. L. (1980) · Spine · doi:10.1097/00007632-198001000-00009 · Cited by 289
The epidemiology of vertebral fractures
Cooper, C. C., O’Neill, T. W., & Silman, A. J. (1993) · Bone · doi:10.1016/8756-3282(93)90358-h · Cited by 241
Biomechanics of Osteoporosis and Vertebral Fracture
Myers, E. R., & Wilson, S. E. (1997) · Spine · doi:10.1097/00007632-199712151-00005 · Cited by 237
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- KopperdahlDL:Structural Consequences of Damage on the Mechanical Behavior of the Human Vertebral Body[Ph.D.dissertation]. Department of Mechanical Engineering Berkeley California University of California Berkeley 1998
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Karim, L., Hussein, A. I., Vaidya, R., Morgan, E. F., & Bouxsein, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00013-7 · Cited by 2
Jin, Y., Wang, Y.-C., Zhang, T. G., Li, J., Wong, T. M., Cheung, J. P. Y., & Lu, W. W. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104865 · Cited by 1
Oravec, D. J., Zauel, R. R., Flynn, M. J., Rao, S. D., & Yeni, Y. N. (2025) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2025.112815 · Cited by 1
Construction of finite element vertebral models from X-rays
Templeton, A. K., & Liebschner, M. A. K. (2002) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2002.1053420 · Cited by 1
Nagasao, T., Miyamoto, J., Jiang, H., Tamaki, T., & Kaneko, T. (2010) · Journal of Plastic Surgery and Hand Surgery · doi:10.3109/02844311.2010.483106 · Cited by 1
“7+3230QCT, where E and QCT mean the Young’s modulus and CT density, respectively [13].”
BackgroundNagasao, T., Miyanagi, T., Tamai, M., Hatano, A., Sakamoto, Y., & TAKANO, N. (2022) · PubMed Central · Cited by 1
Ayari, H., Thomas, M., & Doré, S. (2005) · Perspectives interdisciplinaires sur le travail et la santé · doi:10.4000/pistes.3202 · Cited by 1
Trabecular Microarchitecture, Endplate Failure, and the Biomechanics of Human Vertebral Fractures
Fields, A. J. (2010) · eScholarship (California Digital Library) · Cited by 1
Time-sequence of biomechanical adaption in trabecular tissue during estrogen deficiency
O’Sullivan, L. (2020) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17271 · Cited by 1
Biomechanical efficacy of prophylactic vertebroplasty with respect to initial bone mineral density
Sun, K., & Liebschner, M. A. K. (2002) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2002.1053392
Kim, D., Dong, X., Cao, T., Baker, K. C., Shaffer, R. R., & Fyhrie, D. P. (2012)
Loomis, D. A. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Monotonic and cyclic behaviour of trabecular bone under uniaxial and multiaxial loading
Januddi, M. S., & Januddi, M. A. F. M. S. (2015)
Luo, J., Dolan, P., Adams, M. A., & Annesley-Williams, D. J. (2021) · European Spine Journal · doi:10.1007/s00586-021-07013-w
“The mechanical properties of fractured vertebrae are largely determined by trabecular bone damage [3, 5], which may include fractures of individual trabeculae, or more diffuse damage and microcracks.”
BackgroundResultInfluentialBone as a Material: Lessons From Nature
O’Sullivan, L., & McNamara, L. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.12099-5
Nagasao, T., Miyanagi, T., Wu, L., Akaike, M., Hosokawa, A., & Sakamoto, Y. (2023) · PubMed Central
Biomechanics of Bone Tissue and Its Interactions with Surrounding Tissues
de Brosses, E. S. , & Mitton, D. (2024) · doi:10.1002/9781394306596.ch9
Jin, M., Li, Y., Wang, J., Zhou, Q., Liu, Z., & Guo, P. (2026) · JOR Spine · doi:10.1002/jsp2.70158
Guo, Z., bao, J., Zhang, L., Shi, R., Yang, S., Zhang, L., & bao, J. (2026) · Research Square · doi:10.21203/rs.3.rs-10388541/v1
Metadata
- Authors
- Kopperdahl, D. L., Pearlman, J. L., & Keaveny, T. M.
- Affiliations
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- Corresponding author
- Keaveny, Tony M.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 18
- Issue
- 5
- Pages
- 685-690
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2087738478
- Cited by
- 120
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Funders
- Stryker
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41481)
- Topics
- Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- vertebral body, residual strain, bone stiffness, ultimate load, bone mineral density, trabecular bone, mechanical damage, compressive loading, permanent deformation, lumbar vertebrae, thoracic vertebrae
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cadaver, Humans, Lumbar Vertebrae, Middle Aged, Random Allocation, Stress, Mechanical, Thoracic Vertebrae, Tomography, X-Ray Computed, Bone Density, Weight-Bearing, Pliability, Compressive Strength
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