Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model
Open accessAbstract
Enhanced primary repair of the ACL using a collagen scaffold loaded with platelets has been shown to improve the functional healing of suture repair in animal models. In this study, our objectives were to determine if lowering the platelet concentration would reduce the structural properties of the repaired ACL and increase postoperative knee laxity. Eight Yucatan mini‐pigs underwent bilateral suture repair. In one knee, the repair was augmented with a collagen scaffold saturated with platelet‐rich plasma (PRP) containing five times the systemic baseline of platelets (5×) while the contralateral knee had a collagen scaffold saturated with PRP containing three times the systemic baseline of platelets (3×). After 13 weeks of healing, knee joint laxity and the structural properties of the ACL were measured. The 3× platelet concentration resulted in a 24.1% decrease in cellular density of the repair tissue (p < 0.05), but did not significantly decrease the structural properties [3× vs. 5×: 362 N vs. 291 N (p = 0.242) and 70 N/mm vs. 53 N/mm (p = 0.189) for the yield load and linear stiffness, respectively]. The 3× platelet concentration also did not significantly change the mean anteroposterior knee laxity at 30° and 90° of flexion [5× vs. 3×: 3.5 mm vs. 5.1 mm (p = 0.140), and 6.1 mm vs. 6.3 mm (p = 0.764)] but did result in a lower AP laxity at 60° [5× vs. 3×: 8.6 mm vs. 7.3 mm (p = 0.012)]. The decrease in platelet concentration from 5× to 3× to enhance suture repair of the ACL did not significantly harm the mechanical outcomes in this animal model. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1002–1007, 2011
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In a pig model of bilateral ACL repair, the highest PRP load led to greater fibroblastic concentration, more organized collagen, and higher cellularity and vascular subscores of the LTMI.
“The highest PRP load led to greater fibroblastic concentration, more organized collagen, and higher cellularity and vascular subscores of the LTMI.”
From Molecular and Biologic Effects of Platelet-Rich Plasma (PRP) in Ligament and Tendon Healing and Regeneration: A Systematic Review (2023) · cites this paper as [52]
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Kocher, M. S., Saxon, H. S., Hovis, W. D., et al. (2002) · Journal of Pediatric Orthopaedics · doi:10.1097/01241398-200207000-00008 · Cited by 494 · see citing works
Murray, M. M., Spindler, K. P., Abreu, E., Muller, J. A., Nedder, A., Kelly, M., Frino, J., Zurakowski, D., Valenza, M., Snyder, B. D., et al. (2007) · Journal of Orthopaedic Research · doi:10.1002/jor.20282 · Cited by 321 · see citing works
Self-citationMurray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., & Nanney, L. B. (2007) · Journal of Orthopaedic Research · doi:10.1002/jor.20367 · Cited by 300 · see citing works
Self-citationBosch, G., van Schie, H. T. M., de Groot, M. W., Cadby, J. A., van de Lest, C. H. A., Barneveld, A., & van Weeren, P. R. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20980 · Cited by 269 · see citing works
Activity Level and Graft Type as Risk Factors for Anterior Cruciate Ligament Graft Failure
Borchers, J. R., Pedroza, A. D., & Kaeding, C. C. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546509340633 · Cited by 226 · see citing works
Koman, J. D., & Sanders, J. O. (1999) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199905000-00014 · Cited by 212 · see citing works
Joshi, S. M., Mastrangelo, A. N., Magarian, E. M., Fleming, B. C., & Murray, M. M. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546509339915 · Cited by 175 · see citing works
Self-citationFleming, B. C., Spindler, K. P., Palmer, M. P., Magarian, E. M., & Murray, M. M. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546509332257 · Cited by 134 · see citing works
Self-citationEnhanced flexor tendon healing through controlled delivery of PDGF‐BB
Thomopoulos, S., Das, R., Silva, M. J., Sakiyama‐Elbert, S. E., Harwood, F. L., Zampiakis, E., Kim, H. M., Amiel, D., & Gelberman, R. H. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20875 · Cited by 108 · see citing works
The Effect of Skeletal Maturity on Functional Healing of the Anterior Cruciate Ligament
Murray, M. M., Magarian, E. M., Harrison, S. L., Mastrangelo, A. N., Zurakowski, D., & Fleming, B. C. (2010) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.i.01368 · Cited by 100 · see citing works
Self-citationThomopoulos, S., Kim, H. M., Das, R., Silva, M. J., Sakiyama‐Elbert, S. E., Amiel, D., & Gelberman, R. H. (2010) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.i.01601 · Cited by 100 · see citing works
Mohtadi, N., & Grant, J. A. (2006) · Clinical Journal of Sport Medicine · doi:10.1097/01.jsm.0000248844.39498.1f · Cited by 98 · see citing works
Fleming, B. C., Carey, J. L., Spindler, K. P., & Murray, M. M. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20690 · Cited by 83 · see citing works
Self-citationMurray, M. M., Magarian, E. M., Zurakowski, D., & Fleming, B. C. (2010) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2009.12.017 · Cited by 75 · see citing works
Self-citationSpindler, K. P., Murray, M. M., Carey, J. L., Zurakowski, D., & Fleming, B. C. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20785 · Cited by 69 · see citing works
Self-citationFleming, B. C., Magarian, E. M., Harrison, S. L., Paller, D. J., & Murray, M. M. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21071 · Cited by 65 · see citing works
Self-citationMastrangelo, A. N., Haus, B. M., Vavken, P., Palmer, M. P., Machan, J. T., & Murray, M. M. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21070 · Cited by 63 · see citing works
Self-citationThe effect of skeletal maturity on the regenerative function of intrinsic ACL cells
Mastrangelo, A. N., Magarian, E. M., Palmer, M. P., Vavken, P., & Murray, M. M. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.21018 · Cited by 59 · see citing works
Self-citationEffects of platelet-rich plasma on intestinal wound healing in pigs
Fresno, L., Fondevila, D., Bambo, O. R., et al. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.06.009 · Cited by 59 · see citing works
Translational Studies in Anterior Cruciate Ligament Repair
Vavken, P., & Murray, M. M. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0147 · Cited by 47 · see citing works
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Cenni, E., Avnet, S., Fotia, C., Salerno, M., & Baldini, N. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21073 · Cited by 39 · see citing works
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- [21]Murray MM Magarian EM Harrison SL Skeletal maturity signficantly affects functional healing of the anterior cruciate ligament. J Bone Joint Surg, Am 2009 Vol submitted PMC2924734 20810854
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Chalidis, B., Givissis, P., Papadopoulos, P., & Pitsilos, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032744 · Cited by 74 · see citing works
“[52] augmented the bilateral ACL repair with a PRPcollagen scaffold having platelet concentration of either five or three times the systemic baseline of platelets.”
Yoshida, R., Cheng, M., & Murray, M. M. (2014) · Journal of Orthopaedic Research · doi:10.1002/jor.22493 · Cited by 67 · see citing works
Self-citationLaPrade, R. F., Goodrich, L. R., Phillips, J., Dornan, G. J., Turnbull, T. L., Hawes, M. L., Dahl, K. D., Coggins, A. N., Kisiday, J., Frisbie, D., et al. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517741135 · Cited by 51 · see citing works
Effect of anterior cruciate healing on the uninjured ligament insertion site
Haus, B. M., Mastrangelo, A. N., & Murray, M. M. (2012) · Journal of Orthopaedic Research · doi:10.1002/jor.21498 · Cited by 13 · see citing works
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- Authors
- Mastrangelo, A. N., Vavken, P., Fleming, B. C., Harrison, S. L., & Murray, M. M.
- Affiliations
- Boston Children's Hospital (US)
- Brown University (US)
- Corresponding author
- Murray, Martha M.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2011-02-18
- Volume
- 29
- Issue
- 7
- Pages
- 1002-1007
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- PMC
- PMC3094496
- OpenAlex
- W2081856839
- Cited by
- 88
- References
- 21
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049199, R01AR054099, AR054099, AR052772, R01AR052772, AR049199)
- Topics
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- platelet-rich plasma, anterior cruciate ligament repair, platelet concentration, collagen scaffolds, suture repair, knee laxity, ligament mechanical properties, tissue repair, porcine model
- MeSH terms
- Animals, Biomechanical Phenomena, Blood Platelets, Collagen, Female, Knee Joint, Male, Platelet Count, Swine, Swine, Miniature, Wound Healing, Anterior Cruciate Ligament, Orthopedic Procedures, Recovery of Function, Models, Animal, Platelet-Rich Plasma, Tissue Scaffolds
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