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Cited by 13Knee injuries and reconstruction techniquesTendon Structure and TreatmentPeriodontal Regeneration and Treatments

Effect of anterior cruciate healing on the uninjured ligament insertion site

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Haus, Brian M., Mastrangelo, Ashley N., Murray, Martha M.·2012·Journal of Orthopaedic Research
DOI 10.1002/jor.21498PMC PMC3220740
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Abstract

The effect of anterior cruciate healing on the uninjured ligament insertion site after enhanced suture repair with collagen‐platelet composites (CPC) has not yet been defined. In this study, we hypothesized that fibroblasts and osteoclasts would participate in generating histologic changes in insertion site morphology after transection and bioenhanced repair of the ACL, and that these changes would be age‐dependent. Skeletally immature, adolescent, and adult Yucatan mini‐pigs underwent ACL transection and bioenhanced suture repair. The histologic response to repair of the insertion site was evaluated at 1, 2, 4, and 15 weeks. In young and adolescent animals treated with bioenhanced suture repair with CPC, changes in the insertion site included: (1) fibroblastic proliferation with loss and return of collagen alignment in the fibrous zone; (2) osteoclastic resorption within fibrocartilage zones at 2–4 weeks; and (3) partial reappearance of fibrocartilage zones at 15 weeks. In adult animals; however, degenerative changes were noted by 15 weeks: (1) loss of parallel arrangement of collagen fibers in the fibrous zone; and (2) increasing disorganization and loss of columnation of chondrocytes in the fibrocartilage zone. These results suggest that fibroblasts and osteoclasts mediate histologic changes at the insertion site during bioenhanced suture repair of the ACL which may prevent insertion site degeneration, and that the magnitude of these changes may be a function of skeletal maturity. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:86–94, 2012

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  • In a porcine ACL rupture model, collagen-PRP composite augmentation displayed more advanced remodeling at the insertion site, hypercellularity and increased collagen organization at the fibrous zone.

    “The augmentation group displayed more advanced remodeling at the insertion site, hypercellularity and increased collagen organization at the fibrous zone.”

    From Molecular and Biologic Effects of Platelet-Rich Plasma (PRP) in Ligament and Tendon Healing and Regeneration: A Systematic Review (2023) · cites this paper as [49]

    The Results (Histology Results; page not provided) report insertion-site remodeling, fibrous-zone hypercellularity, and increased collagen organization after bioenhanced repair in immature and adolescent pigs. The claim omits the age qualification: adult pigs showed little healing and insertion-site changes consistent with degeneration. (LLM, conf=0.87)

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Authors
Haus, B. M., Mastrangelo, A. N., & Murray, M. M.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Haus, Brian M.
ORCID
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2011-07-11
Volume
30
Issue
1
Pages
86-94
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.21498
PMC
PMC3220740
OpenAlex
W1988958001
Cited by
13
References
33
Citations by year
2023: 1 · 2022: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Orthopaedic Research and Education Foundation
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054099)
Topics
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
anterior cruciate ligament, ligament healing, insertion site, fibroblasts, osteoclasts, fibrocartilage, collagen fiber alignment, skeletal maturity, Yucatan minipig
MeSH terms
Anterior Cruciate Ligament Injuries, Age Factors, Animals, Biomechanical Phenomena, Blood Platelets, Capillaries, Collagen, Fibroblasts, Swine, Swine, Miniature, Tendon Injuries, Wound Healing, Anterior Cruciate Ligament, Weight-Bearing

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