Towards the in vivo prediction of fragility fractures with Raman spectroscopy

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Measuring Differences in Compositional Properties of Bone Tissue by Confocal Raman Spectroscopy

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Raman spectroscopy reveals differences in collagen secondary structure which relate to the levels of mineralisation in bones that have evolved for different functions

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Functional adaptation of long bone extremities involves the localized “tuning” of the cortical bone composition; evidence from Raman spectroscopy

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Bone Mechanical Properties in Healthy and Diseased States

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Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone

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Assessing glycation‐mediated changes in human cortical bone with Raman spectroscopy

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Magnesium whitlockite – omnipresent in pathological mineralisation of soft tissues but not a significant inorganic constituent of bone

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Effect of short-term formaldehyde fixation on Raman spectral parameters of bone quality

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Finite Element Assessment of Bone Fragility from Clinical Images

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Detection of early osteogenic commitment in primary cells using Raman spectroscopy

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Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations

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Raman Spectroscopy in Skeletal Tissue Disorders and Tissue Engineering: Present and Prospective

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Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality

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Spatially offset Raman spectroscopy for photon migration studies in bones with different mineralization levels

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Raman Spectroscopy for Advanced Polymeric Biomaterials

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Raman spectroscopic determination of bone matrix quantity and quality augments prediction of human cortical bone mechanical properties

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Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water

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Raman fingerprints as promising markers of cellular senescence and aging

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Bone health: Quality versus quantity

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Bone Samples Extracted from Embalmed Subjects Are Not Appropriate for the Assessment of Bone Quality at the Molecular Level Using Raman Spectroscopy

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Recent advances in linear and non‐linear Raman spectroscopy. Part X

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Integrating computational and experimental advances in bone multiscale mechanics

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Sensitivity of the amide I band to matrix manipulation in bone: a Raman micro-spectroscopy and spatially offset Raman spectroscopy study

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Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands

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Altered Collagen Chemical Compositional Structure in Osteopenic Women with Past Fractures: A Case-control Raman Spectroscopic Study

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Self-absorption corrected non-invasive transmission Raman spectroscopy (of biological tissue)

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Time-gated Raman spectroscopy for biomedical application under ambient or strong background light conditions

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Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy

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Raman Spectroscopy identifies differences in ochronotic and non-ochronotic cartilage; a potential novel technique for monitoring ochronosis

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In Vivo Assessment of Bone Quality Without X-rays

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Identifying Bone Matrix Impairments in a Mouse Model of Neurofibromatosis Type 1 (NF1) by Clinically Translatable Techniques

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Evaluation of the optimal dosage of BMP-9 through the comparison of bone regeneration induced by BMP-9 versus BMP-2 using an injectable microparticle embedded thermosensitive polymeric carrier in a rat cranial defect model

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Lock‐in detection in Raman spectroscopy with charge‐shifting CCD for suppression of fast varying backgrounds

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Metacarpophalangeal Joint Pathology and Bone Mineral Density Increase with Exercise but Not with Incidence of Proximal Sesamoid Bone Fracture in Thoroughbred Racehorses

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Soft‐tissue spectral subtraction improves transcutaneous Raman estimates of murine bone strength in vivo

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Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms

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Optimizing number of Raman spectra using an artificial neural network guided Monte Carlo simulation approach to analyze human cortical bone

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Spatially Offset Raman Spectroscopy toward In Vivo Assessment of the Adipose Tissue in Cardiometabolic Pathologies

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Multivariate analysis of Raman spectra for discriminating human collagens: In vitro identification of extracellular matrix collagens produced by an osteosarcoma cell line

Ingle, I., Kerns, J. G., & Shepherd, R. F. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125434 · Cited by 6 · see citing works

3.7 Raman Spectroscopy

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A Bone Sample Containing a Bone Graft Substitute Analyzed by Correlating Density Information Obtained by X-ray Micro Tomography with Compositional Information Obtained by Raman Microscopy

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Short-term and long-term effects of osteoporosis on incisor teeth and femoral bones evaluated by Raman spectroscopy and energy dispersive X-ray analysis in ovariectomized rats

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“Lessons from Rare Forms of Osteoarthritis”

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Model-Based Optimization of Laser Excitation and Detection Improves Spectral Contrast in Noninvasive Diffuse Raman Spectroscopy

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Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model

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Determining ideal offsets of spatially offset Raman spectroscopy for transcutaneous measurements—A Monte Carlo study

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Predicting bone aging using spatially offset Raman spectroscopy: a longitudinal analysis on mice

Dou, H., Sun, W., Chen, S., & Chen, K. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-05819-x · Cited by 4 · see citing works

Predicting fracture toughness of human cortical bone from donors with and without type 2 diabetes using Raman spectroscopy and machine learning

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Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy – a cadaveric study

Hosseini, M., Afrin, S., Yosick, A., Schenker, E., Awad, H., & Berger, A. J. (2026) · Biomedical Optics Express · doi:10.1364/boe.583075 · Cited by 2 · see citing works

Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy

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Raman spectroscopy based framework for in-vivo assessment of bone composition

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The potential of nitisinone for the treatment of alkaptonuria

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Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands

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Subtype-specific bone mineralization defects and early treatment amelioration in murine models of autosomal recessive osteopetrosis revealed by Raman spectroscopy

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Machine learning reconstruction of digit bone Raman spectra enables noninvasive transcutaneous detection of systemic osteoporosis

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Rethinking bone quality after FDA qualification of total hip BMD as a surrogate endpoint

Kawaguchi, H. (2026) · Bone Reports · doi:10.1016/j.bonr.2026.101968

Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy – a cadaveric study

Hosseini, M., Afrin, S., Yosick, A., Schenker, E., Awad, H., & Berger, A. J. (2026) · Biomedical Optics Express · doi:10.1364/boe.583075 · Cited by 2 · see citing works

Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients: results of a prospective study

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Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality

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Spectroscopic roadmap to non-ionizing radiation bone screening

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Novel Assessment of Bone Using Time-Resolved Transcutaneous Raman Spectroscopy

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