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Cited by 121Vestibular and auditory disordersHearing, Cochlea, Tinnitus, GeneticsHearing Loss and Rehabilitation

Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials

Crane, Ryan A., Camilon, Marc, Nguyen, Shaun, Meyer, Ted A.·2015·The Laryngoscope
DOI 10.1002/lary.24834
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Abstract

Objective To systematically review the available evidence regarding steroid treatment for sudden sensorineural hearing loss (SSHL) and to update prior analyses when possible. Data sources OVID Medline. Review methods An electronic database search (OVID Medline) was performed with the objective of identifying all randomized controlled trials examining the use of steroids for the treatment of SSHL. The search was limited to English-language publications between January 1980 and June 2013. Reference lists were examined for additional articles. Results A total of 15 articles including 1,166 subjects were included in three separate analyses. Three articles (181 subjects) were included in the steroid versus placebo analysis, which resulted in an odds ratio of 1.52 (95% confidence interval [CI]: 0.83-2.77). Six articles (702 subjects) were included in the systemic versus intratympanic steroids analysis, which resulted in an odds ratio of 1.14 (95% CI: 0.82-1.59). Six articles (283 subjects) were included in the salvage treatment analysis, which resulted in an odds ratio of 6.04 (95% CI: 3.26-11.2). Conclusions A meta-analysis of randomized controlled trials does not support the use of steroids over placebo in this condition, a finding consistent with previous analyses. Although systemic or intratympanic steroid administration does not have a significant treatment effect, steroids for salvage treatment of patients failing traditional therapy appear to have an effect. However, this re…

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  • Oral systemic corticosteroids and salvage intratympanic steroid injections have been shown to be comparatively efficacious when given adjunctively.

    “Current clinical practice guidelines for SSNHL include the administration of oral, systemic corticosteroids and/or salvage intratympanic (IT) steroid injections [2], though they have been shown to be comparatively efficacious when given adjunctively [3].”

    From Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss (2025) · cites this paper as [3]

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Authors
Crane, R. A., Camilon, M., Nguyen, S., & Meyer, T. A.
Affiliations
  • University of Cincinnati (US)
  • Medical University of South Carolina (US)
Corresponding author
Crane, Ryan A.
ORCID
Venue
The Laryngoscope
Publisher
Wiley
Published
2014-07-21
Volume
125
Issue
1
Pages
209-217
ISSN
  • 0023-852X (ISSN-L)
  • 1531-4995
DOI
10.1002/lary.24834
OpenAlex
W1595956243
Cited by
120
References
35
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 13 · 2015: 5 · 2014: 2
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Laryngoscope (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
Keywords
sudden sensorineural hearing loss, corticosteroids, systemic corticosteroids, intratympanic corticosteroids, salvage therapy, hearing recovery, placebo comparison
MeSH terms
Administration, Topical, Adrenal Cortex Hormones, Audiometry, Pure-Tone, Hearing Loss, Sudden, Dexamethasone, Drug Administration Routes, Ear, Middle, Humans, Methylprednisolone, Prednisolone, Prednisone, Speech Discrimination Tests, Speech Reception Threshold Test, Odds Ratio, Randomized Controlled Trials as Topic, Salvage Therapy

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