Cited by 109Olfactory and Sensory Function StudiesSinusitis and nasal conditionsHead and Neck Surgical Oncology

Postinfectious olfactory loss: A retrospective study on 791 patients

Cavazzana, Annachiara, Larsson, Maria, Münch, Marcus, Hähner, Antje, Hummel, Thomas·2018·The Laryngoscope

Abstract

Objectives/Hypothesis: Postinfectious olfactory loss is among the most common causes of olfactory impairment and has substantial negative impact on patients' quality of life. Recovery rates have been shown to spontaneously improve in most of patients, usually within 2 to 3 years. However, existing studies are limited by small sample sizes and short follow‐up. We aimed to assess the prognostic factors for recovery in a large sample of 791 patients with postinfectious olfactory disorders. Study Design: Retrospective cohort. Methods: We performed a retrospective analysis of 791 patients with postinfectious olfactory loss. Olfactory functions were assessed using the Sniffin' Sticks test at the first and final visits (mean follow‐up = 1.94 years). Results: Smell test scores improved over time. In particular, patient's age and the odor threshold (T), odor discrimination (D), and odor identification (I) (TDI) score at first visit were significant predictors of the extent of change. The percentage of anosmic and hyposmic patients exhibiting clinically significant improvement was 46% and 35%, respectively. Conclusions: This study provides new evidence within the postinfectious olfactory loss literature, shedding light on the prognostic factors and showing that recovery of olfactory function is very frequent, even many years after the infection. Level of Evidence: 4. Laryngoscope, 128:10–15, 2018

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Crossref · 10.1002/lary.26606

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Authors
Cavazzana, A., Larsson, M., Münch, M., Hähner, A., & Hummel, T.
Affiliations
  • Stockholm University (SE)
  • Technische Universität Dresden (DE)
  • Smell and Taste Clinic Technical University of Dresden Dresden Germany
Corresponding author
Cavazzana, Annachiara
Venue
The Laryngoscope
Publisher
Wiley
Published
2017-05-29
Volume
128
Issue
1
Pages
10-15
ISSN
  • 0023-852X (ISSN-L)
  • 1531-4995
OpenAlex
W2617219070
Cited by
109
References
29
Citations by year
2026: 3 · 2025: 8 · 2024: 6 · 2023: 12 · 2022: 23 · 2021: 24 · 2020: 24 · 2019: 6 · 2018: 2 · 2017: 1
FWCI
5.63
Type
journal article
Language
en
Open access
closed
Locations
  • The Laryngoscope (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft to T.H. (DFG HU411/18-1)
  • Swedish Foundation for Humanities and Social Sciences to M.L. (M14-0375:1)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
Keywords
olfactory dysfunction, prognostic factors, odor threshold, odor discrimination, odor identification, Sniffin' Sticks, anosmia, hyposmia, quality of life
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Olfaction Disorders, Female, Humans, Male, Middle Aged, Prognosis, Quality of Life, Respiratory Tract Infections, Retrospective Studies, Risk Factors, Sensory Thresholds, Recovery of Function

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