Exercise capacity and muscle strength in patients with cirrhosis
Open accessAbstract
Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes. Liver Transpl 18:146–151, 2012. © 2011 AASLD.
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Patients with cirrhosis have significantly reduced exercise capacity and muscle strength that might adversely affect clinical outcomes.
“Patients with cirrhosis also have significantly reduced exercise capacity and muscle strength that might adversely affect clinical outcomes.114”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [114]
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Cites
(2014) · Medical Entomology and Zoology · Cited by 9,400 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
Physical Activity and Public Health in Older Adults
Nelson, M. E., Rejeski, W. J., Blair, S. N., Duncan, P. W., Judge, J. O., King, A. C., Macera, C. A., & Castaneda‐Sceppa, C. (2007) · Circulation · doi:10.1161/circulationaha.107.185650 · Cited by 2,991 · see citing works
NELSON, M. E., REJESKI, W. J., BLAIR, S. N., DUNCAN, P. W., JUDGE, J. O., KING, A. C., MACERA, C. A., & CASTANEDA-SCEPPA, C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180616aa2 · Cited by 2,089 · see citing works
MANCINI, D. M., Eisen, H. J., Kussmaul, W. G., Mull, R., Edmunds, L. H., & Wilson, J. R. (1991) · Circulation · doi:10.1161/01.cir.83.3.778 · Cited by 1,879 · see citing works
Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis
Montaño‐Loza, A. J., Meza–Junco, J., Prado, C. M. M., Lieffers, J. R. L., Baracos, V. E., Bain, V. G., & Sawyer, M. B. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.028 · Cited by 814 · see citing works
Exercise Capacity and the Risk of Death in Women: The St James Women Take Heart Project
Gulati, M., Pandey, D. K., Arnsdorf, M. F., Lauderdale, D. S., Thisted, R. A., Wicklund, R. H., Al-Hani, A. J., & Black, H. R. (2003) · Circulation · doi:10.1161/01.cir.0000091080.57509.e9 · Cited by 739 · see citing works
Haddad, E., Wells, G. A., Sigal, R. J., Boul�, N. G., & Kenny, G. P. (2003) · Diabetologia · doi:10.1007/s00125-003-1160-2 · Cited by 601 · see citing works
Wind, A. E., Takken, T., Helders, P. J. M., & Engelbert, R. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-009-1010-4 · Cited by 583 · see citing works
Anaerobic Threshold: The Concept and Methods of Measurement
Svedahl, K., & MacIntosh, B. R. (2003) · Canadian Journal of Applied Physiology · doi:10.1139/h03-023 · Cited by 474 · see citing works
Mayo, N. E., Feldman, L. S., Scott, S. C., Zavorsky, G. S., Kim, D. J., Charlebois, P., Stein, B., & Carli, F. (2011) · Surgery · doi:10.1016/j.surg.2011.07.045 · Cited by 449 · see citing works
Church, T. S., LaMonte, M. J., Barlow, C. E., & Blair, S. N. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.18.2114 · Cited by 445 · see citing works
Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease
Sietsema, K. E., Amato, A., Adler, S. G., & Brass, E. P. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00411.x · Cited by 334 · see citing works
The cardiac response to exercise in cirrhosis
Wong, F. S.-H., Girgrah, N., Graba, J., et al. (2001) · Gut · doi:10.1136/gut.49.2.268 · Cited by 296 · see citing works
Six-minute walk distance predicts mortality in liver transplant candidates
Carey, E. J., Steidley, E. D., Aqel, B. A., Byrne, T., Mekeel, K. L., Rakela, J. L., Vargas, H. E., & Douglas, D. D. (2010) · Liver Transplantation · doi:10.1002/lt.22167 · Cited by 294 · see citing works
Letter: Thoracic-duct cannulation for bleeding oesophageal varices.
Aderka, D. (1976) · PubMed · Cited by 191 · see citing works
Physical exercise increases portal pressure in patients with cirrhosis and portal hypertension
García‐Pagán, J. C., Santos, C., Barberà, J. A., Luca, A., Roca, J., Rodriguez‐Roisin, R., Bosch, J., & Rodés, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8898644 · Cited by 176 · see citing works
Guide to Clinical Preventive Services
Stegbauer, C. C. (1990) · The Nurse Practitioner · doi:10.1097/00006205-199002000-00016 · Cited by 166 · see citing works
EVIDENCE FOR DOWN-REGULATION OF BETA-2-ADRENOCEPTORS IN CIRRHOTIC PATIENTS WITH SEVERE ASCITES
Gerbes, A., Jüngst, D., Remien, J., et al. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91556-4 · Cited by 157 · see citing works
Impact of Impaired Aerobic Capacity on Liver Transplant Candidates
Dharancy, S., Lemyze, M., Boleslawski, E., Nevière, R., Declerck, N., Canva, V., Wallaert, B., Mathurin, P., & Pruvot, F. R. (2008) · Transplantation · doi:10.1097/tp.0b013e318187758b · Cited by 149 · see citing works
Aerobic capacity is associated with 100-day outcome after hepatic transplantation
Epstein, S. K., Freeman, R. B., Khayat, A., Unterborn, J. N., Pratt, D. S., & Kaplan, M. M. (2004) · Liver Transplantation · doi:10.1002/lt.20088 · Cited by 145 · see citing works
Roig, M., Eng, J. J., MacIntyre, D. L., ROAD, J. D., & Reid, W. D. (2011) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e3181f68ae4 · Cited by 112 · see citing works
Andersen, H., Borre, M., Jakobsen, J., Andersen, P. H., & Vilstrup, H. (1998) · Hepatology · doi:10.1002/hep.510270503 · Cited by 105 · see citing works
Submaximal oxygen consumption in liver cirrhosis
Campillo, B., Fouet, P., Bonnet, J. C., et al. (1990) · Journal of Hepatology · doi:10.1016/0168-8278(90)90046-t · Cited by 86 · see citing works
Analysis of Impaired Exercise Capacity in Patients with Cirrhosis
Epstein, S. K., Ciubotaru, R. L., Zilberberg, M. D., Kaplan, L. M., Jacoby, C., Freeman, R. B., & Kaplan, M. M. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018867232562 · Cited by 80 · see citing works
Haemodynamic response to exercise in patients with alcoholic liver cirrhosis
Kelbæk, H., Rabøl, A., Brynjolf, I., et al. (1987) · Clinical Physiology · doi:10.1111/j.1475-097x.1987.tb00631.x · Cited by 69 · see citing works
Guenther F. Wiesinger, M. Q. (2001) · Journal of Rehabilitation Medicine · doi:10.1080/165019701753236446 · Cited by 64 · see citing works
Pieber, K., Crevenna, R., Nuhr, M. J., Quittan, M., Peck‐Radosavljevic, M., Fialka‐Moser, V., & Wiesinger, G. (2006) · Journal of Rehabilitation Medicine · doi:10.1080/16501970600680288 · Cited by 53 · see citing works
Effects of treadmill exercise on fuel metabolism in hepatic cirrhosis
DeLissio, M., Goodyear, L. J., Fuller, S. P., Krawitt, E. L., & Devlin, J. T. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.1.210 · Cited by 43 · see citing works
Improvement of Physical Capacity after Long-Term Training in Patients with Chronic Active Hepatitis
Ritland, S., Cf, P., Knudsen, T., et al. (1983) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528309181845 · Cited by 42 · see citing works
Hormonal and metabolic changes during exercise in cirrhotic patients
Campillo, B., Chapelain, C., Bonnet, J. C., Frisdal, É., Devanlay, M., Bouissou, P., Fouet, P., Wirquin, E., & Atlan, G. (1990) · Metabolism · doi:10.1016/0026-0495(90)90142-y · Cited by 36 · see citing works
EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS
Terziyski, K. V., Andonov, V., Marinov, B. I., et al. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04751.x · Cited by 27 · see citing works
Tarter, R. E., Panzak, G. L., Switala, J., et al. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03748.x · Cited by 20 · see citing works
Tarter, R. E., Panzak, G. L., Switala, J., et al. (1997) · PubMed · Cited by 19 · see citing works
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Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102 · see citing works
EASL Clinical Practice Guidelines on nutrition in chronic liver disease
Merli, M., Berzigotti, A., Zelber-Sagi, S., Dasarathy, S., Montagnese, S., Genton, L., Plauth, M., & Parés, A. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.024 · Cited by 1,130 · see citing works
Sarcopenia from mechanism to diagnosis and treatment in liver disease
Dasarathy, S., & Merli, M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.040 · Cited by 608 · see citing works
Resistance training increases muscle strength and muscle size in patients with liver cirrhosis
Aamann, L., Dam, G., Borre, M., Drljevic-Nielsen, A., Overgaard, K., Andersen, H., Vilstrup, H., & Aagaard, N. K. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.07.058 · Cited by 108 · see citing works
Liver transplantation arrests and reverses muscle wasting
Bergerson, J. T., Lee, J., Furlan, A., Sourianarayanane, A., Fetzer, D. T., Tevar, A. D., Landsittel, D. P., DiMartini, A. F., & Dunn, M. A. (2015) · Clinical Transplantation · doi:10.1111/ctr.12506 · Cited by 43 · see citing works
Wallen, M. P., Skinner, T. L., Pavey, T. G., Hall, A., Macdonald, G. A., & Coombes, J. S. (2016) · Transplantation Reviews · doi:10.1016/j.trre.2016.07.004 · Cited by 30 · see citing works
Evaluation of recipients with significant comorbidity - patients with cardiovascular disease
Tsochatzis, E. A., Watt, K. D., VanWagner, L. B., Verna, E. C., & Berzigotti, A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.023 · Cited by 22 · see citing works
- Authors
- Jones, J. C., Coombes, J. S., & Macdonald, G. A.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Macdonald, Graeme A.
- Venue
- Liver Transplantation
- Published
- 2012-02
- Volume
- 18
- Issue
- 2
- Pages
- 146-151
- ISSN
- 1527-6465 (ISSN-L)
- OpenAlex
- W2072828164
- Cited by
- 133
- References
- 35
- Citations by year
- 2025: 6 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 16 · 2017: 14 · 2016: 13 · 2015: 11 · 2014: 17 · 2013: 4 · 2012: 4
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Liver Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- liver cirrhosis, exercise capacity, muscle strength, exercise training, muscle atrophy, catabolic state, disease severity, outcome prediction
- MeSH terms
- Exercise Therapy, Humans, Liver Cirrhosis, Waiting Lists, Liver Transplantation, Treatment Outcome, Exercise Tolerance, Muscle, Skeletal, Muscle Weakness, Recovery of Function, Muscle Strength
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