The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Injectable Biodegradable Hydrogels
Open accessAbstract
Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered. magnified image
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Cites
A review of chitin and chitosan applications
Ravi Kumar, M. N. V. (2000) · Reactive and Functional Polymers · doi:10.1016/s1381-5148(00)00038-9 · Cited by 6,009
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Biodegradable block copolymers as injectable drug-delivery systems
Jeong, B., Bae, Y. H., Lee, D. S., & Kim, S. W. (1997) · Nature · doi:10.1038/42218 · Cited by 1,997
Self-citationInjectable hydrogels as unique biomedical materials
Yu, L., & Ding, J. (2008) · Chemical Society Reviews · doi:10.1039/b713009k · Cited by 1,545
Thermosensitive sol-gel reversible hydrogels
Jeong, B., Kim, S. W., & Bae, Y. H. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00242-3 · Cited by 1,478
Novel injectable neutral solutions of chitosan form biodegradable gels in situ
Chenite, A., Chaput, C., Wang, D., Combes, C., Buschmann, M. D., Hoemann, C. D., Leroux, J. C., Atkinson, B. L., Binette, F., & Selmani, A. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00116-2 · Cited by 1,406
In situ-forming hydrogels--review of temperature-sensitive systems
Ruel-Gariépy, E., & Leroux, J.-C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.019 · Cited by 1,297
Reversible Hydrogels from Self-Assembling Artificial Proteins
Petka, W. A., Harden, J. L., McGrath, K. P., Wirtz, D., & Tirrell, D. A. (1998) · Science · doi:10.1126/science.281.5375.389 · Cited by 1,076
Degradable poly (β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA
Lynn, D. M., & Langer, R. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0015388 · Cited by 924
In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery
He, C., Kim, S. W., & Lee, D. S. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.01.005 · Cited by 867
Self-citation
Cited by
Shear-thinning hydrogels for biomedical applications
Guvendiren, M., Lu, H. D., & Burdick, J. A. (2012) · Soft Matter · doi:10.1039/c1sm06513k · Cited by 911
Zhao, X., Liang, Y., Huang, Y., He, J., Han, Y., & Guo, B. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910748 · Cited by 814
Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering
Moreira Teixeira, L. S., Feijen, J., van Blitterswijk, C. A., Dijkstra, P. J., & Karperien, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.067 · Cited by 615
Injectable alginate hydrogels for cell delivery in tissue engineering
Bidarra, S. J., Barrias, C. C., & Granja, P. L. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.006 · Cited by 534
Hydrogels: Methods of Preparation, Characterisation and Applications
H. Gulrez, S. K., Al-Assaf, S., & O, G. (2011) · Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications · doi:10.5772/24553 · Cited by 403
Metadata
- Authors
- Nguyen, M. K., & Lee, D. S.
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2010-06-09
- Volume
- 10
- Issue
- 6
- Pages
- 563-579
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W1997143754
- Cited by
- 481
- References
- 102
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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