The DOI matches its Crossref record; 193 of the 194 references it cites were found in a registry or an index.
Poly (2-oxazoline) s as polymer therapeutics
Open accessAbstract
Poly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Poly(2-oxazoline) (POx)-based block copolymers recently gained a lot of interest as novel biomaterials due to their biocompatibility and chemical versatility [44, 45].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [44]
The cited source says what the claim attributes to it.
In the citing paper
“One novel drug carrier system that stands apart from the others in that regard is polymeric micelles [11], based on amphiphilic block copolymers of poly(2-alkyl-2-oxazoline)s and specifically the poly[(2-methyl-2-oxazoline)-b-(2-butyl-2-oxazoline)-b-(2-methyl-2-oxazoline)] (P(MeOx-BuOx-MeOx) triblock copolymer [12].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Encyclopedia of polymer science and engineering
Mark, H., & Kroschwitz, J. I. (1985) · Wiley eBooks · Cited by 5,877
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
The dawning era of polymer therapeutics
Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,312
Designing dendrimers for biological applications
Lee, C., MacKay, J. A., Fréchet, J. M. J., & Szoka, F. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1171 · Cited by 2,046
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,844
Poly(2‐oxazoline)s: A Polymer Class with Numerous Potential Applications
Hoogenboom, R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901607 · Cited by 892
Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821
Kumar, M., Grzelakowski, M., Zilles, J. L., Clark, M. M., & Meier, W. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708762104 · Cited by 717
Pluronic® block copolymers for overcoming drug resistance in cancer
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00047-9 · Cited by 637
Self-citation
Flagged first, then by citations
1 of the 194 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
- Schwekendiek K., 2006, Synthesis, 18, 2996
- Luxenhofer R., 2006, PMSE Prepr., 95, 283
- Kowalczuk A., 2011, Polym. Int.
- Weber C., 2011, Prog. Polym. Sci.
- Luxenhofer R., 2007, Thesis TU München, Garching
- Harris J. M., 2010, 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, 19
- Hruby M., 2010, Macromol. Biosci.
- Schulz A., 2012, Polym. Prepr., 53, 354
- Schulz A., 2012, Polym. Prepr., 53, 305
- Bender J. C. M. E., 2011, PCT Int. Appl. WO 2011/002285
Cited by
Sorted by citations
Items 401–470 of 470
Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers
Majerčíková, M., Nádaždy, P., Chorvat, D., Jr., Satrapinskyy, L., Valentová, H., Kroneková, Z., Šiffalovič, P., Kronek, J., & Zahoranová, A. (2021) · Polymers · doi:10.3390/polym13091357 · Cited by 3
Moreadith, R. W., & Viegas, T. X. (2017) · doi:10.1002/9781118967904.ch3 · Cited by 3
Guyse, J. F. R. V., & Hoogenboom, R. (2022) · doi:10.1002/9783527815562.mme0012 · Cited by 3
Schumann, K. P., Lutz, T., & Leiske, M. N. (2025) · Journal of Polymer Science · doi:10.1002/pol.20241179 · Cited by 2
Nurlanovna, M. D., Tolegenova, D. A., Abiyeva, A. M., Serikbayevna, I. G., Mun, G. A., Smyslov, R. Y., Gorshkova, Y. E., Ivanova, V. E., Tomilin, F. N., & Khutoryanskiy, V. V. (2026) · Polymer · doi:10.1016/j.polymer.2026.130028 · Cited by 2
Panchal, P., Daware, S., Guo, Y., Mao, G.-M., Billack, B., Khatri, P., & Patel, K. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03455-x · Cited by 2
Storti, G., Romano, G., Gilmore, K., Sadowski, N., Tiiara, A., Luzinov, I. A., & Sidorenko, A. (2023) · Coatings · doi:10.3390/coatings13061007 · Cited by 2
Rezaei, Z., Abolmaali, S. S., Salmanpour, M., Mohammadi, S., Borandeh, S., & Tamaddon, A. M. (2023) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-023-02877-5 · Cited by 2
Shahiwala, A., & Shaikh, K. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95496-9.00007-7 · Cited by 2
Percec, V., & Sahoo, D. (2024) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202400339 · Cited by 2
Nanoarmored Enzymes for Organic Enzymology
Leurs, M., & Tiller, J. C. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.01.008 · Cited by 2
Polymeric Nanoparticles as Theranostics for Targeting Solid Tumors
Gautam, L., Thakur, P. S., Goel, I., Sankar, M., Jain, A., Shrivastava, P., Vyas, S., & Vyas, S. P. (2022) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-031-14848-4_10 · Cited by 2
The role of nanotechnology: Organic nanomaterials and the mechanism of cancer phototheranostics
Bukhari, S. Z., Iftikhar, M., Ihsan, A., & Younis, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95758-8.00008-3 · Cited by 2
Poly(2-oxazoline)–protein conjugates
Sedláček, O., de la Rosa, V. R., & Hoogenboom, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64081-9.00018-8 · Cited by 2
Surface Functionalization of Biomaterials by Poly(2‐oxazoline)s
Morgese, G., & Benetti, E. M. (2017) · doi:10.1002/9781118967904.ch15 · Cited by 2
Effects of Dietary Fatty Acid Saturation on Broiler Chickens Subjected to High Ambient Temperatures
Htin, N. N. (2005) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 2
Stimulus‐Responsive Nanoparticles for Therapeutic Stabilization of Atherosclerosis
Mehta, S., Ahamad, N., Dewani, M., Bhardwaj, P., & Banerjee, R. (2021) · Wiley eBooks · doi:10.1002/9783527832095.ch7 · Cited by 2
Hu, C., Ahmad, T., Haider, M. S., Hahn, L., Stahlhut, P., Gröll, J., & Luxenhofer, R. (2021) · ChemRxiv · doi:10.26434/chemrxiv.14447676 · Cited by 2
Self-citationKamiyama-Ueda, M., Ueki, T., Kamiyama, Y., Tamate, R., Watanabe, K., & Katsumoto, Y. (2025) · Chemical Communications · doi:10.1039/d5cc01017a · Cited by 1
Kirila, T. Y., Козина, Н. Д., Головина, М. А., Sokolova, M. P., Теньковцев, А. В., & Филиппов, А. П. (2025) · Soft Matter · doi:10.1039/d5sm00337g · Cited by 1
An azide-containing initiator for the cationic ring-opening-polymerization of 2-oxazolines
Meyer, J., Weber, C., Liebing, P., & Schubert, U. S. (2026) · European Polymer Journal · doi:10.1016/j.eurpolymj.2026.114515 · Cited by 1
Oleszko-Torbus, N., Mendrek, B., Fus-Kujawa, A., Kowalczuk, A., & Bochenek, M. (2026) · Polymer Chemistry · doi:10.1039/d5py01158b · Cited by 1
Muta, T., Koppisetti, H., & Garg, S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030336 · Cited by 1
Espo, E., Potdar, D., Baas, K., Keßler, L., Yang, M., Bērziņš, K., Kemell, M., Kiiskinen, T., Heinonen, A., Kehrein, J., et al. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04109-0 · Cited by 1
Self-citationPoly(2-oxazoline)s: a versatile polymers shaping the future of biomedical innovations
shinde, S., Dargude, S., Gholap, A. D., Jagdale, S., & Rajput, A. (2026) · Discover Chemistry. · doi:10.1007/s44371-026-00728-z · Cited by 1
Nano- and Microcomposites for Electrical Engineering Applications
Wiesbrock, F. (2016) · MDPI eBooks · doi:10.3390/books978-3-03842-293-8 · Cited by 1
Dalkılıç, E., & Güneş, Y. (2023) · Synlett · doi:10.1055/s-0042-1751491 · Cited by 1
Parrott, M. C., & Dunn, S. S. (2018) · Polymers and polymeric composites · doi:10.1007/978-3-319-92066-5_10-1 · Cited by 1
Tunable Swelling Kinetics of Shape-Memory Poly(2-Ethyl-2-Oxazoline)-Networks
Segiet, D., Tiller, J. C., & Katzenberg, F. (2019) · Materials Today Proceedings · doi:10.1016/j.matpr.2019.05.340 · Cited by 1
Parrott, M. C., & Dunn, S. S. (2019) · Polymers and polymeric composites · doi:10.1007/978-3-319-95990-0_10 · Cited by 2
Chen, A. Y.-W. (2013) · VTechWorks (Virginia Tech) · Cited by 1
Haider, M. S., Mahato, A. K., Котлярова, А. А., Forster, S., Böttcher, B., Stahlhut, P., Sidorova, Y. A., & Luxenhofer, R. (2021) · ChemRxiv · doi:10.33774/chemrxiv-2021-ffsvz · Cited by 1
Self-citationPoly(2-oxazoline) architectures for drug delivery systems
Park, J. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.211439 · Cited by 1
Simon, L., Constanzo, J., Benkhaled, B. T., Terraza‐Aguirre, C., Berthelot, J., Pednekar, K. P., Clark, K. C., Emerson, S. J., Atis, S., Elfekih, Z. I., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4826812 · Cited by 1
Pippa, Ν., Pispas, S., & Demetzos, C. (2015) · doi:10.1002/9781119041559.ch11
Polymere Nanopartikel als Formulierung für die Krebstherapie
Papadakis, C. M. (2019) · Springer eBooks · doi:10.1007/978-3-662-58035-6_26
Smart polymer composites for wood protection
Husaini, A., Sing, N. N., Fun, C. S., Roslan, H. A., Vincent, M., & Ho, W.-S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819961-9.00014-1
Advances in Thermoresponsive Polymers
Sponchioni, M. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4011-5
Oxazoline and caprolactone based polymeric materials
Patil, N. A., & Kandasubramanian, B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823797-7.00010-1
Hussain, E. A., Ghani, A., & Sadiq, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85386-6.00008-1
Bolat, Z. B., Nezir, A. E., Saka, O. M., ZEMHERİ, I. E., Gülyüz, S., Özköse, U. U., Yılmaz, Ö., Bozkır, A., Telci, D., & ŞAHİN, F. (2024) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2706
Тарабукина, Е. Б., Krasova, A., Kurlykin, M. P., Теньковцев, А. В., & Филиппов, А. П. (2025) · Journal of Polymer Research · doi:10.1007/s10965-025-04297-0
Exploring the Solubility Characteristics of a Biocompatible Polymer: The Case of PAmOx in Water
Galdo, S. D., Ricci, A., Stefanuto, L., Filippo, C. A. D., Masci, G., Bruni, F., Gasperi, T., & Capone, B. (2025) · Journal of Applied Polymer Science · doi:10.1002/app.57722
Georgieva, D., Bogdanova, I., Mihaylova, R., Alexandrova, M., Bozhilova, S., Christova, D., & Kostova, B. (2025) · Gels · doi:10.3390/gels11080629
Hubina, A. V., Lobko, Y., Khalakhan, I., & Khrunyk, Y. Y. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01774b
Kaberov, L. I., Godbole, A., Klement, L., Achikkulathu, S., Chettri, A., Dietzek‐Ivanšić, B., Hoffmann, C., & Schacher, F. H. (2025) · Macromolecular Rapid Communications · doi:10.1002/marc.202500455
Ibragimova, A., Berdnikova, D. V., Kipping, M., Raghu, S. N. V., Killian, M. S., & Jonas, U. (2025) · Macromolecular Materials and Engineering · doi:10.1002/mame.202500300
Nurlanovna, M. D., Tolegenova, D. A., Serikbayevna, I. G., Mun, G. A., Smyslov, R. Y., Gorshkova, Y. E., Ivanova, V. E., Tomilin, F. N., & Khutoryanskiy, V. V. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6044694
A Direction Beyond Next Generation Glycoprotein Drug
Kanie, O. (2025) · KAGAKU TO SEIBUTSU · doi:10.1271/kagakutoseibutsu.63.82
Chemical-Aware Autoencoders for Eco-Selective Adsorption of Wastewater Contaminants
Meconcelli, D., Prete, A. L., Costanti, F., Bacconi, S., Giordano, E., Stefanuto, L., Gasperi, T., Scarselli, F., & Bianchini, M. (2025) · IEEE International Workshop on Metrology for Green Technologies, Renewable Energy and Ecological Sustainability (MetroGREENST) · doi:10.1109/metrogreenst67435.2025.11428885
End‐Group‐Dependent Host–Guest Complexation of Poly(2‐ethyl‐2‐oxazoline) with β‐Cyclodextrin
Karslıoğlu, S. (2026) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202500369
Bochenek, M., Mendrek, B., Kowalczuk, A., Olszowska, K., Sieroń, Ł., Gawron, K., & Oleszko-Torbus, N. (2026) · Polymer Chemistry · doi:10.1039/d5py01190f
Clean synthesis of novel green surfactants
Baheti, P. (2018) · theses.fr (ABES) · doi:10.70675/50ba2f7cz05e7z4c87z9bb6z3886f4f4cb0f
Fonctionnalisation chimique de membranes nanoporeuses pour la mise en oeuvre de filtres commutatifs
Benaoudia, D. (2018) · theses.fr (ABES) · doi:10.70675/81321d35zf729z4417z846bz2f0ff9bec09f
Synthèse et auto-assemblage de copolymères thermosensibles à partir de poly(2-alkyl-2-oxazoline)
Glaive, A.-S. (2019) · theses.fr (ABES) · doi:10.70675/cdaa5978zda3cz489fz9db2z114fa376360b
Matériaux polymères à base de phosphore et de poly(2-oxazoline) pour la sorption d’ions métalliques
Benkhaled, B. T. (2020) · theses.fr (ABES) · doi:10.70675/1d225ac2zc987z473dzae10z67dd6630052a
Tanaka, Y., Morikawa, S., & Osawa, S. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504206
Amino Functionalized Poly(2-oxazoline)s: Synthesis and Specific Applications in Biology and Medicine
Oleszko-Torbus, N., & Haladjova, E. (2026) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2026.2670277
Czich, S., Schirmer, U., Hoffmann, T., Wloka, T., Behrendt, F., Rothe, H., Wetzel, A., Engel, N., Gottschaldt, M., Schubert, U. S., et al. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116372
Chi, Y., Barakhtii, D. D., Centanni, A., Aseyev, V. O., Ekholm, F. S., Sarparanta, M. P., Luxenhofer, R., & Imlimthan, S. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.6c00871
Self-citationSynthesis and Characterization of Poly(vinylidene fluoride)- g -poly(oxazoline) Graft Copolymers
Özköse, U. U., Gimello, O., Eid, N., Devisme, S., Bonnet, A., Lapinte, V., & Ameduri, B. M. (2026) · Macromolecules · doi:10.1021/acs.macromol.6c00246
Degey, M., Pedergnana, S., Évrard, B., Piel, G., Debuigne, A., & Berger, M. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2699381
Hulugalla, K., Fortenberry, A. W., de Silva, D. J., & Werfel, T. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04173-6
Bochenek, M., Popova, M. D., Oleszko-Torbus, N., Kowalczuk, A., Utrata‐Wesołek, A., Mitova, V. A., Koseva, N. S., Grządka, E., Orzeł, J., & Mendrek, B. (2026) · Materials · doi:10.3390/ma19173775
Kawka, A., Koenig, H., & Pospieszny, T. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119408
Tavano, R., Gervasutti, R., Battisti, I., Arrigoni, G., Morillas, L., Romio, M., Benetti, E. M., Mancin, F., & Papini, E. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.6c01334
Metadata
- Authors
- Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R.
- Affiliations
- Technische Universität Dresden (DE)
- Wuhan University of Technology (CN)
- University of Nebraska Medical Center (US)
- Center for Regenerative Therapies Dresden (DE)
- Corresponding author
- Luxenhofer, Robert
- Jordan, Rainer
- Venue
- Macromolecular Rapid Communications
- Publisher
- Wiley
- Published
- 2012-08-03
- Volume
- 33
- Issue
- 19
- Pages
- 1613-1631
- ISSN
- 1022-1336 (ISSN-L)
- 1521-3927
- PMC
- PMC3608391
- OpenAlex
- W2065735911
- Cited by
- 470
- References
- 194
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 28 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 43 · 2019: 43 · 2018: 47 · 2017: 39 · 2016: 42 · 2015: 37 · 2014: 28 · 2013: 23 · 2012: 3
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Macromolecular Rapid Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- China Scholarship Council
- Zentrum für Regenerative Therapien Dresden
- National Cancer Institute (U01 CA116591, U01CA151806, R01CA116591)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- poly(2-oxazoline), polymer therapeutics, biocompatibility, protein-polymer conjugates, polymer-drug conjugates, polyplexes, micelles, drug delivery, biomaterials
- MeSH terms
- Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Micelles, Oxazoles, Polymers, Proteins, Nanomedicine, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
