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Poly (2-oxazoline) s as polymer therapeutics
Open accessAbstract
Poly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.
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“Poly(2-oxazoline) (POx)-based block copolymers recently gained a lot of interest as novel biomaterials due to their biocompatibility and chemical versatility [44, 45].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [44]
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“One novel drug carrier system that stands apart from the others in that regard is polymeric micelles [11], based on amphiphilic block copolymers of poly(2-alkyl-2-oxazoline)s and specifically the poly[(2-methyl-2-oxazoline)-b-(2-butyl-2-oxazoline)-b-(2-methyl-2-oxazoline)] (P(MeOx-BuOx-MeOx) triblock copolymer [12].”
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First Aldehyde‐Functionalized Poly(2‐oxazoline)s for Chemoselective Ligation
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Self-citationNew Amphiphilic Poly(2-ethyl-2-oxazoline)/ Poly( l -lactide) Triblock Copolymers
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Polymer-tethered membranes as quantitative models for the study of integrin-mediated cell adhesion
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Self-citationPolyoxazoline‐Peptide adducts that retain antibody avidity
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Transbilayer coupling of obstructed lipid diffusion in polymer-tethered phospholipid bilayers
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Self-citationSolid‐supported biomimetic membranes with tailored lipopolymer tethers
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Self-citationSynthesis and surfactant property of copolymers having a poly(2‐oxazoline) graft chain
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α,ω‐Functionalized Poly(2‐Oxazoline)s Bearing Hydroxyl and Amino Functions
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Self-citationMicrowave-assisted synthesis and micellization behavior of soy-based copoly(2-oxazoline)s
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Self-citationA nonionic hydrogel from the telechelics by utilizing living polymerization of 2‐oxazolines
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Self-citation
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Metadata
- Authors
- Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R.
- Affiliations
- Technische Universität Dresden (DE)
- Wuhan University of Technology (CN)
- University of Nebraska Medical Center (US)
- Center for Regenerative Therapies Dresden (DE)
- Corresponding author
- Luxenhofer, Robert
- Jordan, Rainer
- Venue
- Macromolecular Rapid Communications
- Publisher
- Wiley
- Published
- 2012-08-03
- Volume
- 33
- Issue
- 19
- Pages
- 1613-1631
- ISSN
- 1022-1336 (ISSN-L)
- 1521-3927
- PMC
- PMC3608391
- OpenAlex
- W2065735911
- Cited by
- 470
- References
- 194
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 28 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 43 · 2019: 43 · 2018: 47 · 2017: 39 · 2016: 42 · 2015: 37 · 2014: 28 · 2013: 23 · 2012: 3
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Macromolecular Rapid Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- China Scholarship Council
- Zentrum für Regenerative Therapien Dresden
- National Cancer Institute (U01 CA116591, U01CA151806, R01CA116591)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- poly(2-oxazoline), polymer therapeutics, biocompatibility, protein-polymer conjugates, polymer-drug conjugates, polyplexes, micelles, drug delivery, biomaterials
- MeSH terms
- Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Micelles, Oxazoles, Polymers, Proteins, Nanomedicine, Nanoparticles
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