The DOI matches its Crossref record; 193 of the 194 references it cites were found in a registry or an index.
Poly (2-oxazoline) s as polymer therapeutics
Open accessAbstract
Poly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Poly(2-oxazoline) (POx)-based block copolymers recently gained a lot of interest as novel biomaterials due to their biocompatibility and chemical versatility [44, 45].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [44]
The cited source says what the claim attributes to it.
In the citing paper
“One novel drug carrier system that stands apart from the others in that regard is polymeric micelles [11], based on amphiphilic block copolymers of poly(2-alkyl-2-oxazoline)s and specifically the poly[(2-methyl-2-oxazoline)-b-(2-butyl-2-oxazoline)-b-(2-methyl-2-oxazoline)] (P(MeOx-BuOx-MeOx) triblock copolymer [12].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Encyclopedia of polymer science and engineering
Mark, H., & Kroschwitz, J. I. (1985) · Wiley eBooks · Cited by 5,877
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
The dawning era of polymer therapeutics
Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,312
Designing dendrimers for biological applications
Lee, C., MacKay, J. A., Fréchet, J. M. J., & Szoka, F. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1171 · Cited by 2,046
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,844
Poly(2‐oxazoline)s: A Polymer Class with Numerous Potential Applications
Hoogenboom, R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901607 · Cited by 892
Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821
Kumar, M., Grzelakowski, M., Zilles, J. L., Clark, M. M., & Meier, W. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708762104 · Cited by 717
Pluronic® block copolymers for overcoming drug resistance in cancer
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00047-9 · Cited by 637
Self-citation
Research works printed but not linked: 10
- Schwekendiek K., 2006, Synthesis, 18, 2996
- Luxenhofer R., 2006, PMSE Prepr., 95, 283
- Kowalczuk A., 2011, Polym. Int.
- Weber C., 2011, Prog. Polym. Sci.
- Luxenhofer R., 2007, Thesis TU München, Garching
- Harris J. M., 2010, 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, 19
- Hruby M., 2010, Macromol. Biosci.
- Schulz A., 2012, Polym. Prepr., 53, 354
- Schulz A., 2012, Polym. Prepr., 53, 305
- Bender J. C. M. E., 2011, PCT Int. Appl. WO 2011/002285
Cited by
Sorted by citations
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,759
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,279
Polymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 882
Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699
Self-citationThermo-responsive polymers and their application as smart biomaterials
Kim, Y.-J., & Matsunaga, Y. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00157f · Cited by 568
Metadata
- Authors
- Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R.
- Affiliations
- Technische Universität Dresden (DE)
- Wuhan University of Technology (CN)
- University of Nebraska Medical Center (US)
- Center for Regenerative Therapies Dresden (DE)
- Corresponding author
- Luxenhofer, Robert
- Jordan, Rainer
- Venue
- Macromolecular Rapid Communications
- Publisher
- Wiley
- Published
- 2012-08-03
- Volume
- 33
- Issue
- 19
- Pages
- 1613-1631
- ISSN
- 1022-1336 (ISSN-L)
- 1521-3927
- PMC
- PMC3608391
- OpenAlex
- W2065735911
- Cited by
- 470
- References
- 194
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 28 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 43 · 2019: 43 · 2018: 47 · 2017: 39 · 2016: 42 · 2015: 37 · 2014: 28 · 2013: 23 · 2012: 3
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Macromolecular Rapid Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- China Scholarship Council
- Zentrum für Regenerative Therapien Dresden
- National Cancer Institute (U01 CA116591, U01CA151806, R01CA116591)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- poly(2-oxazoline), polymer therapeutics, biocompatibility, protein-polymer conjugates, polymer-drug conjugates, polyplexes, micelles, drug delivery, biomaterials
- MeSH terms
- Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Micelles, Oxazoles, Polymers, Proteins, Nanomedicine, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
