Cited by 470Advanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug Deliverybiodegradable polymer synthesis and properties

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Poly (2-oxazoline) s as polymer therapeutics

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Luxenhofer, Robert, Han, Yingchao, Schulz, Anita, Tong, Jing, He, Zhijian, Kabanov, Alexander V., Jordan, Rainer·2012·Macromolecular Rapid Communications

DOI 10.1002/marc.201200354PMC PMC3608391

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Abstract

Poly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.

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Authors: Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R.
Affiliations: Technische Universität Dresden (DE)
Wuhan University of Technology (CN)
University of Nebraska Medical Center (US)
Center for Regenerative Therapies Dresden (DE)
Corresponding author: Luxenhofer, Robert
Jordan, Rainer
ORCID: Luxenhofer, Robert
Han, Yingchao
Tong, Jing
He, Zhijian
Kabanov, Alexander V.
Jordan, Rainer
Venue: Macromolecular Rapid Communications
Publisher: Wiley
Published: 2012-08-03
Volume: 33
Issue: 19
Pages: 1613-1631
ISSN: 1022-1336 (ISSN-L)
1521-3927
DOI: 10.1002/marc.201200354
PMC: PMC3608391
OpenAlex: W2065735911
Cited by: 470
References: 194
Citations by year: 2026: 22 · 2025: 21 · 2024: 28 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 43 · 2019: 43 · 2018: 47 · 2017: 39 · 2016: 42 · 2015: 37 · 2014: 28 · 2013: 23 · 2012: 3
FWCI: 1.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Macromolecular Rapid Communications (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: China Scholarship Council
Zentrum für Regenerative Therapien Dresden
National Cancer Institute (U01 CA116591, U01CA151806, R01CA116591)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords: poly(2-oxazoline), polymer therapeutics, biocompatibility, protein-polymer conjugates, polymer-drug conjugates, polyplexes, micelles, drug delivery, biomaterials
MeSH terms: Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Micelles, Oxazoles, Polymers, Proteins, Nanomedicine, Nanoparticles

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