The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation
Open accessAbstract
The role of N 6‐methyladenosine (m 6 A) demethylase fat mass and obesity‐associated protein (FTO) in the regulation of chemo‐radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo‐radiotherapy resistance both in vitro and in vivo through regulating expression of β‐catenin by reducing m 6 A levels in its mRNA transcripts and in turn increases excision repair cross‐complementation group 1 (ERCC1) activity. Clinically, the prognostic value of FTO for overall survival is found to be dependent on β‐catenin expression in human CSCC samples. Taken together, these findings uncover a critical function for FTO and its substrate m 6 A in the regulation of chemo‐radiotherapy resistance, which may bear potential clinical implications for CSCC treatment.
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Cites
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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Gene expression regulation mediated through reversible m6A RNA methylation
Fu, Y., Dominissini, D., Rechavi, G., & He, C. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3724 · Cited by 1,935
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FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase
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Cited by
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
The role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 963
The interplay between m6A RNA methylation and noncoding RNA in cancer
Ma, S., Chen, C., Ji, X., Liu, J., Zhou, Q., Wang, G., Yuan, W., Kan, Q., & Sun, Z. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0805-7 · Cited by 632
The role of m6A modification in physiology and disease
Yang, C., Hu, Y., Zhou, B., Bao, Y., Li, Z., Gong, C., Yang, H., Wang, S., & Xiao, Y. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03143-z · Cited by 200
Metadata
- Authors
- Zhou, S., Bai, Z., Xia, D., Zhao, Z., Zhao, R., Wang, Y., & Zhe, H.
- Venue
- Molecular Carcinogenesis
- Publisher
- Wiley
- Published
- 2018-02
- Volume
- 57
- Issue
- 5
- Pages
- 590-597
- ISSN
- 0899-1987 (ISSN-L)
- 1098-2744
- OpenAlex
- W2784196060
- Cited by
- 365
- References
- 35
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhou, S., Bai, Z., Xia, D., Zhao, Z., Zhao, R., Wang, Y., & Zhe, H. (2018). FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation. Molecular Carcinogenesis. https://doi.org/10.1002/mc.22782
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