The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma
Abstract
Ferroptosis is a recently recognized form of regulated cell death driven by lipid‐based reactive oxygen species (ROS) accumulation. However, the molecular mechanisms of ferroptosis regulation are still largely unknown. Here we identified a novel miRNA, miR‐9, as an important regulator of ferroptosis by directly targeting GOT1 in melanoma cells. Overexpression of miR‐9 suppressed GOT1 by directly binding to its 3′‐UTR, which subsequently reduced erastin‐ and RSL3‐induced ferroptosis. Conversely, suppression of miR‐9 increased the sensitivity of melanoma cells to erastin and RSL3. Importantly, anti‐miR‐9 mediated lipid ROS accumulation and ferroptotic cell death could be abrogated by inhibiting glutaminolysis process. Taken together, our findings demonstrate that miR‐9 regulates ferroptosis by targeting GOT1 in melanoma cells, illustrating the important role of miRNA in ferroptosis.
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Cites
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Hensley, C. T., Wasti, A. T., & DeBerardinis, R. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69600 · Cited by 1,262
Cited by
Molecular mechanisms of ferroptosis and its role in cancer therapy
Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14511 · Cited by 639
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 312
Self-citationEmerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Yao, X., Li, W., Fang, D., Xiao, C., Wu, X., Li, M., & Luo, Z. (2021) · Advanced Science · doi:10.1002/advs.202100997 · Cited by 282
Ferroptosis in liver disease: new insights into disease mechanisms
Wu, J., Wang, Y., Jiang, R., Xue, R., Yin, X., Wu, M., & Meng, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00660-4 · Cited by 281
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells
Bai, T., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29496 · Cited by 125
Metadata
- Authors
- Zhang, K., Wu, L., Zhang, P., Luo, M., Du, J., Gao, T., O'Connell, D., Wang, G., Wang, H., & Yang, Y.
- Venue
- Molecular Carcinogenesis
- Publisher
- Wiley
- Published
- 2018-08-14
- Volume
- 57
- Issue
- 11
- Pages
- 1566-1576
- ISSN
- 0899-1987 (ISSN-L)
- 1098-2744
- OpenAlex
- W2884392492
- Cited by
- 171
- References
- 5
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma. https://app.cochat.ai/papers/10.1002/mc.22878
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- Zhang, K., Wu, L., Zhang, P., Luo, M., Du, J., Gao, T., O'Connell, D., Wang, G., Wang, H., & Yang, Y. (2018). miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma. Molecular Carcinogenesis. https://doi.org/10.1002/mc.22878
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