Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

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Items 101–200 of 441

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5. Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation
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7. Radical-Initiated Photodissociation at Tryptophan Residues within Intact Proteins in the Gas Phase
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9. Isoform-Selective PAD2/PAD4 Substrates with Unnatural Amino Acids Enable Cellular Peptidylarginine Deiminase Activity Profiling and Reveal Vimentin Citrullination Effects in Macrophages
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10. Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review
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11. Post-translational modifications regulating microglial inflammation in central nervous system disorders: a review
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12. α-Pinene Improves Follicle Morphology and Increases the Expression of mRNA for Nuclear Factor Erythroid 2-Related Factor 2 and Peroxiredoxin 6 in Bovine Ovarian Tissues Cultured In Vitro
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13. Pharmacologic Induction of ERα SUMOylation Disrupts Its Chromatin Binding
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14. The Activation of the NF-κB Pathway in Human Adipose-Derived Stem Cells Alters the Deposition of Epigenetic Marks on H3K27 and Is Modulated by Fish Oil
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15. Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study
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16. Specific phosphorylation patterns control the interplay between aggregation and condensation of Tau-R4 peptides
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17. Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined in silico and in vitro approach
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21. Assembly of C-Alkyl Glycosides by Pd/NBE-Catalyzed 1,2-Functionalization of Glycals
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22. Large Language Model (LLM)-Based Advances in Prediction of Post-translational Modification Sites in Proteins
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29. Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance
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30. SUMO and SUMOylation in Plants: Ignored Arsenal to Combat Abiotic Stress
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31. IKAROS protein stability is regulated by its early N-terminal region and C-terminal dimerization domain
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35. A systems biology approach to understand temporal evolution of silver nanoparticle toxicity
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37. Protein S-sulfhydration: Mechanisms and therapeutic implications in Alzheimer's disease and Parkinson's disease
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38. Molecular Signatures of Preeclampsia: The Role of Post‐Translational Protein Modifications
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39. Bacterial secondary metabolites as resistance-modifying adjuvants: microbial origins, molecular mechanisms, and translational relevance
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40. Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality
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41. Probing the microRNA landscape in cadmium chloride induced renal toxicity through an in silico approach
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42. Comparison of Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome
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44. Epigenetic and post-translational modifications in ferroptosis regulation and hepatocellular carcinoma: New frontiers in therapeutic targeting.
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45. Post-translational modifications of apolipoproteins as promising biomarkers for diabetes-related cardiovascular diseases: A comprehensive review
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46. Identification of glycosylation-related changes in migratory and mechanical properties of bladder cancer cells
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47. Novel Heterocyclic PAD4 Inhibitors for Treating Multiple Diseases
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48. Cell signaling pathways discovery from multi-modal data
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49. Graphene or MoS 2 nanopores: pore adhesion and protein linearization
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50. Review of Fish Neuropeptides: A Novel Perspective on Animal Welfare
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51. Integrative Phosphoproteomic and Metabolomic Analysis of Disruption of Metabolic Homeostasis in Breast Cancer: A Pilot Study
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52. Association of inflammation and protein carbamylation in patients with COVID-19
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53. Transformative protein scaffold designs for dual-modality cancer applications: Advances in therapeutic delivery and molecular imaging of tumor microenvironments
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54. Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence
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55. Mitochondrial proteomic adaptations to daily torpor in the Djungarian hamster (Phodopus sungorus)
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56. Posttranslational sialylation and its impact on neutrophil recruitment
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57. An efficient machine-learning framework for predicting protein post-translational modification sites
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58. Decoding sexually dimorphic proteomic landscapes in the context of aging and mortality
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60. Protein Lactylation Modulating Regulated Cell Death: A Novel Therapeutic Target in Neurological Diseases
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61. Targeting Cell division cycle 37: A Promising Novel Therapeutic Strategy
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64. Decoding the plasma proteome: Advancing precision medicine in cardiovascular health
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65. Engineered Protein Modification: A New Paradigm for Enhancing Biosensing Sensitivity and Diagnostic Accuracy
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66. The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets
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67. E2F1 K117 methylation by SETD6 disrupts BRD4–E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells
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68. The emerging paradigms of SETD family enzymes as epigenetic regulators of the immune response in inflammatory diseases
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69. Rewriting the viral script: post-translational modifications orchestrating SARS-CoV-2 pathogenesis and immune evasion
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70. Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation
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71. Proteomics in tissue regeneration: insights into protein alterations and post-translational modifications during healing
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72. Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification
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73. Catalytic strategies for post-translational modifications regulating protein higher-order structure and properties
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74. From metabolic substrate to epigenetic regulation: roles and mechanisms of lactylation in brain health and disease
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75. USP24 is a cross-reactive DUB targeting MOV10 to regulate IFN-I production
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76. Highly Dynamic Cytoskeletal Networks Support Productive Viral Infection and Host Innate Immune Response Activation
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77. A Click Chemistry-Based Biorthogonal Approach for the Detection and Identification of Protein Lysine Malonylation for Osteoarthritis Research
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78. Transcriptomic characterization of GMP-compliant regulatory macrophages (TRI-001) under inflammatory and hypoxic conditions: a comparative analysis across macrophage subtypes
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79. Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools
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80. Degradation of Misfolded Proteins in Neurodegenerative Diseases: Therapeutic Targets and Strategies
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82. Comparative Analysis of Proteoform Clean‐Up Methods for In‐Depth Top‐Down Proteomics
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84. Recent advances in serum response factor posttranslational modifications and their therapeutic potential in cardiovascular and neurological diseases
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85. Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) facilitate regulation of central carbon metabolism, enhancement of ATP synthesis and cell wall biosynthesis
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86. Acetylation in Viral Infection and Disease
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88. Downregulation of SMAD2 and SMAD4 is associated with poor prognosis and shorter survival in esophageal squamous cell carcinoma
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89. Disease Dynamics: Insights from Microbiome and Multi-Omics Analysis
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90. SUMO-activating enzyme subunit 1 (SAE1) promotes non-small cell lung cancer metastasis by promoting the epithelial-mesenchymal transition through the SUMOylation of N-cadherin
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91. Harnessing Nanobodies for Precision Targeting of Proteoforms: Opportunities and Challenges in Therapeutics and Diagnostics
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92. Digital Twin-Based Multiscale Models for Biomarker Discovery in Kinase and Phosphatase Tumorigenic Processes
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95. Advances in mucopolysaccharidosis research: the impact of mass spectrometry-based approaches
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96. Pathogen-induced hijacking of host SUMOylation: from molecular mechanisms and prospects for therapeutic modulation
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97. A Multi-PTM omics atlas uncovers novel aging regulators in colorectal cancer
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98. CD147 at the crossroads of glycoprotein networks, metabolic reprogramming, and metastatic progression
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99. Time-restricted feeding ameliorates hepatic lipid and glucose metabolism dysregulation induced by PM2.5 exposure in mice
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100. Taxonomic-Level Protein Quantification in Metaproteomics Using a Biomass-Constrained Expectation–Maximization Approach
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