Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Qian, Xiao, Xina, Qiu, Yijie, Xu, Zhiqiang, Chen, Chunyu, Chong, Baochen, Zhao, Xinjun, Hai, Shan +3 more·2023·MedComm

DOI 10.1002/mco2.261

Cites (1,499)

Items 1,001–1,200 of 1,498

Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Fei Chen, Huirong Yang, Zhenghong Dong, Jian Fang, Ping Wang, Tingting Zhu, Wei Yu Gong, Rui Fang, Yujiang Geno Shi, Ze Li et al. · 2013 · Cell Research
N-Glycans in the gp120 V1/V2 domain of the HIV-1 strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization
Tobias Wolk, Michael Schreiber · 2006 · Medical Microbiology and Immunology
Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding
E Tian, Shengjun Wang, Liping Zhang, Ying Zhang, May Christine V. Malicdan, Yang Mao, Christina Christoffersen, Lawrence A. Tabak, Katrine T.-B. G. Schjoldager, Kelly G. Ten Hagen · 2019 · Proceedings of the National Academy of Sciences
The dynamics of linear polyubiquitin
Alexander Jussupow, Ana C. Messias, Ralf Stehle, Arie Geerlof, Sara M. Ø. Solbak, Cristina Paissoni, Anders Bach, Michael Sattler, Carlo Camilloni · 2020 · Science Advances
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang · 2022 · Neuro-Oncology
Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification
Tingting Zhou, Huiwen Xu, Xi Cheng, Yanqiu He, Qian Ren, Dongzhe Li, Yumei Xie, Chenlin Gao, Yuanyuan Zhang, Xiaodong Sun et al. · 2022 · Mediators of Inflammation
PepCyber:P PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains
W. Gong, D. Zhou, Yanan Ren, Y. Wang, Zhixiang Zuo, Ying H. Shen, F. Xiao, Q. Zhu, Ánh Nguyễn Thị Hồng, Xin Zhou et al. · 2007 · Nucleic Acids Research
Glycans in Immunologic Health and Disease
Julie Y. Zhou, Brian A. Cobb · 2021 · Annual Review of Immunology
Redox Signaling and Sarcopenia: Searching for the Primary Suspect
Nicholas A. Foreman, Anton S. Hesse, Li Li Ji · 2021 · International Journal of Molecular Sciences
PI-Specific Phospholipase C Cleavage of a Reconstituted GPI-Anchored Protein: Modulation by the Lipid Bilayer
Marty T. Lehto, Frances Jane Sharom · 2001 · Biochemistry
Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice
Yinping Du, Ping Liu, Tongda Xu, Defeng Pan, Hong Zhu, Nana Zhai, Yanbin Zhang, Dongye Li · 2018 · Cellular Physiology and Biochemistry
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation
Jordan J. Shimell, Bhavin S. Shah, Stuart M. Cain, Samrat Thouta, Naila Kuhlmann, Igor Tatarnikov, D. Blair Jovellar, G. Stefano Brigidi, Jennifer Kass, Austen J. Milnerwood et al. · 2019 · Cell Reports
Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration
Losev, Yelena, Frenkel-Pinter, Moran, Abu-Hussien, Malak, Viswanathan, Guru Krishnakumar, Elyashiv-Revivo, Donna, Geries, Rana, Khalaila, Isam, Gazit, Ehud, Segal, Daniel · 2021 · Cellular and Molecular Life Sciences
PIAS1 Promotes Lymphomagenesis through MYC Upregulation
Andrea Rabellino, Margherita Melegari, Van S. Tompkins, Weina Chen, Brian G. Van Ness, Julie Teruya‐Feldstein, Maralice Conacci‐Sorrell, Siegfried Janz, Pier Paolo Scaglioni · 2016 · Cell Reports
SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice
Xueliang Zhou, Feng-Jian Huang, Yang Li, Huang Huang, Qicai Wu · 2021 · Aging
Neddylation regulation of mitochondrial structure and functions
Qiyin Zhou, Yawen Zheng, Yi Sun · 2021 · Cell & Bioscience
Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology
Meiling Yang, Fernanda Marques Câmara Sodré, Mark J. Mamula, Lut Overbergh · 2021 · Frontiers in Immunology
Glutathione in the Nervous System as a Potential Therapeutic Target to Control the Development and Progression of Amyotrophic Lateral Sclerosis
Kiyoung Kim · 2021 · Antioxidants
Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
Rui R Liu, Jingyi Li, Jichun Shao, Jong-Ho Lee, Xuemei Qiu, Yanxuan Xiao, Bowen Zhang, Yilong Hao, Mi Li, Qianming Chen · 2021 · Cell Metabolism
The pros and the cons of mTOR inhibitors in kidney transplantation
Claudio E. Ponticelli · 2013 · Expert Review of Clinical Immunology
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients
Kristiaan Lenos, Jeroen A. C. M. Goos, Ilona M. Vuist, Sjoerd H. den Uil, Pien M. Delis‐van Diemen, Eric J.T. Belt, Hein B.A.C. Stockmann, Herman Bril, Meike de Wit, Beatriz G. Carvalho et al. · 2015 · Oncotarget
EGF‐like and Other Disulfide‐rich Microdomains as Therapeutic Scaffolds
Benjamin J. Tombling, Conan K. L. Wang, David J. Craik · 2019 · Angewandte Chemie International Edition
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency
Loı̈c Louvet, Damien Leterme, Séverine Delplace, Flore Miellot, Pierre Marchandise, Véronique Gauthier, Pierre Hardouin, Christophe Chauveau, Olfa Ghali Mhenni · 2020 · Bone
Up-regulation of MMP-2 by histone H3K9 β-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat
Weigang Luo, Yijin Yu, Hao Wang, Kun Liu, Yu Wang, Minling Huang, Chenhao Xuan, Yanning Li, Jinsheng Qi · 2020 · Acta Diabetologica
Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation
Jun Tang, Weiyan Peng, Yixiao Feng, Xin Le, Kang Wang, Qin Xiang, Lili Li, Yan Wang, Can Xu, Junhao Mu et al. · 2021 · Oncogene
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion
Yajuan Zhang, Ming Zhao, Hong Gao, Guanzhen Yu, Yun Zhao, Feng Yao, Weiwei Yang · 2022 · Nature Metabolism
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling
Sachin Kumar Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard A. Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David A. Scott, Rabi Murad et al. · 2022 · Nature Cell Biology
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Li Yan, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang et al. · 2022 · Journal of Hematology & Oncology
The SNO/SOH TMT strategy for combinatorial analysis of reversible cysteine oxidations
Katarzyna Wojdyła, James C. Williamson, Peter Roepstorff, Adelina Rogowska-Wrzesińska · 2014 · Journal of Proteomics
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling
Xiaolong Zhu, Sha Ding, Cong Qiu, Yanna Shi, Lin Song, Yueyue Wang, Yuewen Wang, Jinying Li, Yiran Wang, Yi Sun et al. · 2017 · Circulation Research
Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity
Losev, Yelena, Paul, Ashim, Frenkel-Pinter, Moran, Abu-Hussein, Malak, Khalaila, Isam, Gazit, Ehud, Segal, Daniel · 2019 · Scientific Reports
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
Bingyi Chen, Junhong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chunhui Xu, Jichuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang et al. · 2020 · Blood
PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling
Yukinori Tanaka, Yasuhiro Nagai, Mariko Okumura, Mark Irwin Greene, Taku Kambayashi · 2020 · Frontiers in Immunology
Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis
Burg, Thibaut, Rossaert, Elisabeth, Moisse, Matthieu, Van Damme, Philip, Van Den Bosch, Ludo · 2021 · International Journal of Molecular Sciences
Top-Down Targeted Proteomics Reveals Decrease in Myosin Regulatory Light-Chain Phosphorylation That Contributes to Sarcopenic Muscle Dysfunction
Zachery R. Gregorich, Ying Peng, Wenxuan Cai, Yutong Jin, Liming Wei, Albert J. Chen, Susan H. McKiernan, Judd M. Aiken, Richard L. Moss, Gary M. Diffee et al. · 2016 · Journal of Proteome Research
The autoimmune ecology: an update
Juan‐Manuel Anaya, Paula Restrepo-Jiménez, Carolina Ramı́rez-Santana · 2018 · Current Opinion in Rheumatology
Broad and potent antiviral activity of the NAE inhibitor MLN4924
Vu Thuy Khanh Le‐Trilling, Dominik Andre Megger, Benjamin Katschinski, Christine D. Landsberg, Meike U. Rückborn, Sha Tao, Adalbert Krawczyk, Wibke Bayer, Ingo Drexler, Matthias Tenbusch et al. · 2016 · Scientific Reports
Sunitinib in the management of gastrointestinal stromal tumours (GISTs)
Tom Glass Hopkins, Maria Marples, Dan Stark · 2007 · European Journal of Surgical Oncology
Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells
Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Liu · 2015 · The Journal of Toxicological Sciences
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors
Peng Li, Hong-Min Liu · 2020 · European Journal of Medicinal Chemistry
Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy
Beilei Gao, Wenjun Yu, Ping Lv, Xinyue Liang, Shiqun Sun, Yingmei Zhang · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Chemical biology of protein citrullination by the protein A arginine deiminases
Santanu Mondal, Paul R. Thompson · 2021 · Current Opinion in Chemical Biology
SUMO and SUMOylation Pathway at the Forefront of Host Immune Response
T. K. Sajeev, Garima Joshi, Pooja Arya, Vibhuti Mahajan, Akanksha Chaturvedi, Ram Kumar Mishra · 2021 · Frontiers in Cell and Developmental Biology
Myocardial Expression of FOXO3a–Atrogin-1 Pathway in Human Heart Failure
Gennaro Galasso, Roberta De Rosa, Federico Piscione, Guido Iaccarino, Carlo Vosa, Daniela Sorriento, Raffaele Piccolo, Antonio Rapacciuolo, Kenneth Walsh, Massimo Chiariello A · 2010 · European Journal of Heart Failure
Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability
Brittany Ebersole, Jessica Petko, Matthew P. Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Štagljar, Bernhard Lüscher, Robert G. Levenson · 2015 · PLoS ONE
Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation
Jared T. Hammill, Daniel C. Scott, Jaeki Min, Michele Connelly, Gloria Holbrook, Fangyi Zhu, Amy Matheny, Lei Yang, Bhuvanesh Singh, Brenda Arlene Schulman et al. · 2018 · Journal of Medicinal Chemistry
SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation
Jaecheol Lee, Ning‐Yi Shao, David T. Paik, Haodi Wu, Hongchao Guo, Vittavat Termglinchan, Jared M. Churko, Youngkyun Kim, Tomoya Kitani, Mingtao Zhao et al. · 2018 · Cell stem cell
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
Sisi Liu, Yi‐Shi Liu, Xinyu Guo, Yoshiko Murakami, Ganglong Yang, Xiao‐Dong Gao, Taroh Kinoshita, Morihisa Fujita · 2021 · Communications Biology
KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state
Jin Woo Lee, Jin Hur, Yoo‐Wook Kwon, Cheong-Whan Chae, Jae-Il Choi, Injoo Hwang, Jiyeon Yun, Jin-A Kang, Youngeun Choi, Young Hyun Kim et al. · 2021 · Journal of Hematology & Oncology
The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
Zhenzhen Yan, Haifeng M. Wu, Hansen Liu, Guimin Zhao, Honghai Zhang, Wanxin Zhuang, Feng Liu, Yi Zheng, Bingyu Liu, Lei Zhang et al. · 2021 · Cell Reports
Histone Deacetylase 3 Is Required for Efficient T Cell Development
Kristy R. Stengel, Yue Zhao, Nicholas J. Klus, Jonathan F. Kaiser, Laura E. Gordy, Sebastian Joyce, Scott W. Hiebert, Alyssa R. Summers · 2015 · Molecular and Cellular Biology
Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang · 2021 · Cellular and Molecular Life Sciences
Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis
Shuang Zhao, Xin Tang, Zian Miao, Yurong Chen, Jiawei Cao, Tianyu Song, Daiting You, Yanqing Zhong, Zhe Lin, Dan Wang et al. · 2022 · Redox Biology
Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility
Christian M. Orr, Hayden Fisher, Xiaojie Yu, H.T. Claude Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel G Elliott, Tatyana Inzhelevskaya, Christopher Ian Mockridge et al. · 2022 · Science Immunology
USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway
Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du, Huifen Chen · 2020 · BMC Cancer
Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation
Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang, Xueran Chen · 2021 · Stem Cell Research & Therapy
Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
Idil Ulengin-Talkish, Matthew AH Parson, Meredith L. Jenkins, Jagoree Roy, Alexis Z.L. Shih, Nicole St‐Denis, Gergő Gulyás, Tamás Balla, Anne‐Claude Gingras, Péter Várnai et al. · 2021 · Nature Communications
Aloe gel glucomannan induced colon cancer cell death via mitochondrial damage-driven PINK1/Parkin mitophagy pathway
Ke Zhang, Duoduo Zhang, Junqiao Wang, Yuting Wang, Jiarui Hu, Yujia Zhou, Xingtao Zhou, Shaoping Nie, Mingyong Xie · 2022 · Carbohydrate Polymers
Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
Adeline Vitaliano-Prunier, Juliane Halftermeyer, Julien Ablain, Aurélien de Reyniès, Laurent Pérès, Morgane Le Bras, Daniel METZGER, Hugues de Thé · 2014 · Blood
Protein S-glutathionylation: The linchpin for the transmission of regulatory information on redox buffering capacity in mitochondria
Adrian Young, Robert Gill, Ryan J. Mailloux · 2018 · Chemico-Biological Interactions
Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy
Levi W. Evans, Abigail Bender, Leah Burnett, Luis Godoy, Yi Shen, Dante Staten, Tong Zhou, Jeff Erik Angermann, Bradley S. Ferguson · 2020 · The Journal of Nutritional Biochemistry
The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders
Asia Owais, Rama K. Mishra, Hiroaki Kiyokawa · 2020 · Cancers
The effects of histone crotonylation and bromodomain protein 4 on prostate cancer cell lines
Xiaolin Xu, Xin Zhu, Feng Liu, Wenlong Lu, Yihan Wang, Jianjun Yu · 2021 · Translational Andrology and Urology
Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases
Ioanna Andreadou, Panagiotis Efentakis, Katie Frenis, Andreas Daiber, Rainer Schulz · 2021 · Basic Research in Cardiology
Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease
Cheril Tapia‐Rojas, AngieK Torres, BastiánI Rivera, Catalina M. Polanco, Claudia Jara · 2021 · Neural Regeneration Research
The protein arginine methyltransferase PRMT 5 regulates Aβ‐induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease
Xin Quan, Wenhui Yue, Yunfeng Luo, Jianwei Cao, Hongyun Wang, Yue Wang, Zhongbing Lu · 2015 · Journal of Neurochemistry
Cabozantinib: A Review of Its Use in Patients with Medullary Thyroid Cancer
Sheridan M. Hoy · 2014 · Drugs
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors
Wei Guo, Yabing Zheng, Bing Xu, Fang Ma, Chang Li, Xiaoqian Zhang, Yao Wang, Xiaotian Chang · 2017 · OncoTargets and Therapy
Human protein paucimannosylation: cues from the eukaryotic kingdoms
Harry C. Tjondro, Ian Loke, S. Chatterjee, M. Thaysen-Andersen · 2019 · Biological Reviews of The Cambridge Philosophical Society
Targeting SUMOylation in cancer
Li Du, Wei Liu, Steven T. Rosen · 2021 · Current Opinion in Oncology
Protein Inhibitor of Activated STAT3 (PIAS3) Protein Promotes SUMOylation and Nuclear Sequestration of the Intracellular Domain of ErbB4 Protein
Maria Sundvall, Anna Korhonen, Katri Mataleena Vaparanta, Julius Anckar, Kalle Halkilahti, Zaidoun Salah, Rami I. Aqeilan, Jorma J. Palvimo, Lea Sistonen, Klaus Elenius · 2012 · Journal of Biological Chemistry
Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells
Pei-Chen Hsu, Yan-Li Liao, Chin-Li Lin, Wen-hao Lin, Guang-Yaw Liu, Hui-Chih Hung · 2014 · Molecules and Cells
Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Panyu Chen, Mandar Deepak Muzumdar, Kimberly Judith Dorans, Rebecca Robbins, Arjun J. Bhutkar, Amanda M. Del Rosario, Philipp Mertins, Jana Qiao, Claudia Schäfer, Frank B. Gertler et al. · 2017 · Cancer Research
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis
Hua Lu, Charles S. Fermaintt, Natalia A. Cherepanova, Reid Gilmore, Nan Yan, Mark A. Lehrman · 2018 · Proceedings of the National Academy of Sciences
Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders
Julian Ugonotti, Sayantani Chatterjee, Morten Thaysen‐Andersen · 2020 · Molecular Aspects of Medicine
Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine
Shiho Minakata, Shino Manabe, Yoko Inai, Midori Ikezaki, Kazuchika Nishitsuji, Yukishige Ito, Yoshito Ihara · 2021 · Molecules
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2
Ning Dou, Qingqing Hu, Li Li, Qiong Wu, Yandong Li, Yong Gao · 2020 · International Journal of Biological Sciences
The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
Shaun S. Sanders, Luiselys M. Hernandez, Heun Soh, Santi Karnam, Randall S. Walikonis, Anastasios V. Tzingounis, Gareth M. Thomas · 2020 · eLife
The N-glycome regulates the endothelial-to-hematopoietic transition
Dionna M. Kasper, Jared Hintzen, Yinyu Wu, Joey J. Ghersi, Hanna K. Mandl, Kevin E. Salinas, William Armero, Zhiheng He, Ying Sheng, Yixuan Xie et al. · 2020 · Science
Lysine methylation: Implications in neurodegenerative disease
Elyn M. Rowe, Viktoria Xing, Kyle K. Biggar · 2018 · Brain Research
The Role of APP O-Glycosylation in Alzheimer’s Disease
Keiko Akasaka‐Manya, Hiroshi Manya · 2020 · Biomolecules
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential
Roberto Di Blasi, Oleg B. Blyuss, John F. Timms, Daniel Conole, Francesca Ceroni, Harry J. Whitwell · 2021 · ACS Chemical Biology
S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling
Shuang Zhao, Tianyu Song, Ziyu Wang, Jie Gao, Jiawei Cao, Lulu Hu, Zhengrong Huang, Liping Xie, Yong Hua Ji · 2021 · Acta Pharmacologica Sinica
Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy
Weijing Dai, Jian‐Guo Zhang, Siqi Li, Fajian He, Qiao Liu, Jun Gong, Zetian Yang, Yan Qing Gong, Fang Tang, Zhihao Wang et al. · 2022 · Frontiers in Immunology
Identification of an N-Linked Glycosylation in the C4 Region of HIV-1 Envelope gp120 That Is Critical for Recognition of Neighboring CD4 T Cell Epitopes
Hualin Li, Peter C Chien, Michael Tuen, Maria Luisa Visciano, Sandra Cohen, Steven P. Blais, Chong‐Feng Xu, Hui-Tang Zhang, Catarina E. Hioe · 2008 · The Journal of Immunology
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts
Floriane Petit, Anthony Drecourt, Michaël Dussiot, Coralie Zangarelli, Olivier Hermine, Arnold Münnich, Agnès Rötig · 2021 · Blood
Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer
Yizeng Fan, Tao Hou, Yang Gao, Weichao Dan, Tianjie Liu, Bo Liu, Yule Chen, Hongjun Xie, Yang Yu Zhao, Jiaqi Chen et al. · 2021 · Autophagy
A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-I
Yan Liu, Qizhang Liang, Wan Lu, Yong‐Le Yang, Ruiai Chen, Yao‐Wei Huang, Bin Wang · 2021 · Frontiers in Immunology
Role of resveratrol in inhibiting pathological cardiac remodeling
Shaowei Fan, Yuanhui Hu, Yaping You, Wenjing Xue, Ruoning Chai, Xuesong Zhang, Xintian Shou, Jingjing Shi · 2022 · Frontiers in Pharmacology
Association of glutathione-S-transferase with patients of type 2 diabetes mellitus with and without nephropathy
Mohini Sharma, Stuti Gupta, Kalpana Singh, Mohit Mehndiratta, Amar Gautam, Om P. Kalra, Rimi Shukla, Jasvinder Kaur Gambhir · 2016 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
Extensive protein S-nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis
Chaochao Tan, Yunfeng Li, Xiahe Huang, Meijin Wei, Ying Huang, Zhouqin Tang, He Huang, Wen Zhou, Yingchun Wang, Jiliang Hu · 2019 · Cell Death and Disease
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
Jingwen Niu, Shaun S. Sanders, Hey‐Kyeong Jeong, Sabrina M. Holland, Yue Sun, Kaitlin M. Collura, Luiselys M. Hernandez, Haoliang Huang, Michael R. Hayden, George M. Smith et al. · 2020 · Cell Reports
Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits
Dongmei Wang, Luyang Cao, Shunji Pan, Gang Wang, Lewei Wang, Ningyao Cao, Xueqin Hao · 2021 · Food and Chemical Toxicology
Selective and programmed cleavage of GPI-anchored proteins from the surface membrane by phospholipase C
Alexandra Müller, Christine Klöppel, Megan Smith Valentine, Judith Van Houten, Martin C. Simon · 2011 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Carbamylated LL-37 as a modulator of the immune response
Catalin Koro, Annelie Hellvard, Nicolas Delaleu, Veronika Binder, Carsten Scavenius, Brith Bergum, Izabela Główczyk, Helen M. Roberts, Iain Chapple, Melissa M. Grant et al. · 2016 · Innate Immunity
TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1
Mohammad Belayat Hossain, Rehnuma Shifat, David G. Johnson, Mark T. Bedford, Konrad R. Gabrusiewicz, Nahir Cortes‐Santiago, Xuemei Luo, Zhimin Lu, Ravesanker Ezhilarasan, Erik P. Sulman et al. · 2016 · Science Advances
A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis
Cindy Maurel, Anna A. Chami, Rose‐Anne Thépault, Sylviane Marouillat, Hélène Blasco, Philippe Corcia, Christian Robert Andres, Patrick Vourc’h · 2019 · Molecular Neurobiology
Beyond Ruxolitinib: Fedratinib and Other Emergent Treatment Options for Myelofibrosis
Jan Philipp Bewersdorf, Sara Mohamed Jaszczur, Salma Afifi, Jennifer C. Zhao, Amer Methqal Zeidan · 2019 · Cancer Management and Research
Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme
Xueran Chen, Hao Li, Xiaoqing Fan, Chenggang Zhao, Kaiqin Ye, Zhiyang Zhao, Lizhu Hu, Huihui Ma, Hongzhi Wang, Zhiyou Fang · 2020 · Molecular Therapy — Oncolytics
Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
Fanny L. Lemarié, Nicholas S. Caron, Shaun S. Sanders, Mandi E. Schmidt, Yen T.N. Nguyen, Seung‐Hyun Ko, Xiaohong Xu, Mahmoud A. Pouladi, Dale D. O. Martin, Michael R. Hayden · 2021 · Neurobiology of Disease
Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis
Syed Husain Mustafa Rizvi, Di Shao, Yuko Tsukahara, David Richard Pimentel, Robert M. Weisbrod, Naomi M. Hamburg, Mark E. McComb, Reiko Matsui, Markus Michael Bachschmid · 2021 · Free Radical Biology and Medicine
Glycosylation and raft endocytosis in cancer
Ludger Johannes, Anne Billet · 2020 · Cancer and Metastasis Reviews
Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases
Mannix J. Burns, Syed Husain Mustafa Rizvi, Yuko Tsukahara, David Richard Pimentel, Ivan Luptak, Naomi M. Hamburg, Reiko Matsui, Markus Michael Bachschmid · 2020 · International Journal of Molecular Sciences
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma
Xiaoqiang Chai, Jianfei Guo, Rui‐Zhao Dong, Xuan Yang, Chao Deng, Chuanyuan Wei, Jiajie Xu, Weiyu Han, Jia‐Cheng Lu, Chao Gao et al. · 2021 · Clinical and Translational Medicine
Sunitinib in advanced pancreatic neuroendocrine tumors: latest evidence and clinical potential
Catherine Delbaldo, Sandrine J. Faivre, Chantal Dreyer, Éric Raymond · 2011 · Therapeutic Advances in Medical Oncology
Second-generation EGFR and ErbB tyrosine kinase inhibitors as first-line treatments for non-small cell lung cancer
Shouzheng Wang, Junling Li · 2019 · OncoTargets and Therapy
Novel Biomarkers of Hepatitis B and Hepatocellular Carcinoma: Clinical Significance of HBcrAg and M2BPGi
Ian Baudi, Takako Inoue, Yasuhito Tanaka · 2020 · International Journal of Molecular Sciences
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
Bellail, Anita C., Jin, Hong Ri, Lo, Ho-Yin, Jung, Sung Han, Hamdouchi, Chafiq, Kim, Daeho, Higgins, Ryan K., Blanck, Maximilian, le Sage, Carlos, Cross, Benedict C.S. et al. · 2021 · Science Translational Medicine
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis
Hayeong Kwon, Moonjeong Choi, Yujin Ahn, Donghwan Jang, Yunbae Pak · 2022 · Cancer Gene Therapy
The role of protein acetylation in carcinogenesis and targeted drug discovery
Yang, Jingru, Song, Cong, Zhan, Xianquan · 2022 · Frontiers in Endocrinology
Lysine Propionylation Is a Prevalent Post-translational Modification in Thermus thermophilus
Hiroki Okanishi, Kwang Kim, Ryoji Masui, Seiki Kuramitsu · 2014 · Molecular & Cellular Proteomics
Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity
Sadhana A. Samant, Vinodkumar B. Pillai, Nagalingam Ravi Sundaresan, Sanjeev G. Shroff, Mahesh P. Gupta · 2015 · Journal of Biological Chemistry
Basal S -Nitrosylation Is the Guardian of Tissue Homeostasis
Saori Furuta · 2017 · Trends in cancer
Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation
Julia Carracedo, Rafael Ramírez-Carracedo, Irene Martínez de Toda, Carmen Vida, Matilde Alique, Mónica De la Fuente, Rafael Ramı́rez · 2018 · International Journal of Molecular Sciences
Larotrectinib for the treatment of TRK fusion solid tumors
Theodore Willis Laetsch, Douglas S. Hawkins · 2018 · Expert Review of Anticancer Therapy
Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease
Kelly Anne Pike, Michel L. Tremblay · 2018 · Frontiers in Immunology
ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association
Ying Liu, Qian Zhou, Li Zhong, Heng Lin, Ming‐Ming Hu, Yan Zhou, Hong‐Bing Shu, Shu Li · 2018 · Cellular and Molecular Immunology
S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse
Amado Carreras‐Sureda, Laurence Abrami, Ji‐Hee Kim, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex · 2021 · eLife
The Influence of Arginine Methylation in Immunity and Inflammation
Nivine Srour, Sarah Khan, Stéphane Richard · 2022 · Journal of Inflammation Research
Chromatin Modifications Associated with Diabetes
Samuel T. Keating, Assam El‐Osta · 2012 · Journal of Cardiovascular Translational Research
Inactivation of Histone Deacetylase 1 (HDAC1) But Not HDAC2 Is Required for the Glucocorticoid-Dependent CCAAT/Enhancer-Binding Protein α (C/EBPα) Expression and Preadipocyte Differentiation
Claire Kuzmochka, Houssein S. Abdou, Robert J.G. Haché, Ella Atlas · 2014 · Endocrinology
Regulation of dendrite morphology and excitatory synapse formation by zDHHC15
Bhavin S. Shah, Jordan J. Shimell, Shernaz Xerxes Bamji · 2019 · Journal of Cell Science
Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish
Qianwen Ding, Zhen Zhang, Yu Li, Hongliang Liu, Qiang Hao, Yalin Yang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Chao Ran et al. · 2021 · iScience
Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling
Rushita Adhikari Bagchi, Emma Louise Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires Da Silva, Jennifer L. Major et al. · 2022 · Proceedings of the National Academy of Sciences
The Conceivable Functions of Protein Ubiquitination and Deubiquitination in Reproduction
Jiayu Wang, Qi Zhou, Jinli Ding, Tailang Yin, Peng Ye, Yan Zhang · 2022 · Frontiers in Physiology
Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
Lin Dang, Xinyi Cao, Tianye Zhang, Yongzhan Sun, Shanshan Tian, Tianyu Gong, Hui Xiong, Peipei Cao, Yuhao Li, Shengqiang Yu et al. · 2022 · Journal of the American Society of Nephrology
EOGT and O-GlcNAc on secreted and membrane proteins
Shweta Varshney, Pamela Stanley · 2017 · Biochemical Society Transactions
Aberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration
Monika Chauhan, Prashant Kumar Modi, Pushkar Sharma · 2020 · Cell Death and Disease
Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function
Jie Li, Jianqiu Zou, Rodney Littlejohn, Jinbao Liu, Huabo Su · 2020 · Frontiers in Physiology
SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion
Sulagna Sanyal, Payel Mondal, Sabyasachi Sen, Sumita Sengupta, Chandrima Das · 2020 · Biochemical Journal
Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism
Zhi Yang, Minzhen He, Julianne Austin, Jessica M. Pfleger, Maha Abdellatif · 2021 · Molecular Metabolism
Kinase-SUMO networks in diabetes-mediated cardiovascular disease
Eugene B. Chang, Jun‐ichi Abe · 2016 · Metabolism
Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth
Anupama Pal, Michele L. Dziubinski, Marina Pasca di Magliano, Diane M. Simeone, Scott R. Owens, Dafydd G. Thomas, Luke F. Peterson, Harish Potu, Moshe Talpaz, Nicholas J. Donato · 2017 · Neoplasia
The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway
Kaitlin M. Collura, Jingwen Niu, Shaun S. Sanders, Audrey Montersino, Sabrina M. Holland, Gareth M. Thomas · 2020 · Journal of Biological Chemistry
A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress
José A. Martina, David Guerrero‐Gómez, Eva Gómez‐Orte, José Antonio Bárcena, Juan Cabello, Antonio Miranda‐Vizuete, Rosa Puertollano · 2020 · The EMBO Journal
Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway
Xiyue Zhang, Yihua Zhang, Miao Qing, Zhiguang Shi, Lulu Hu, Shangmin Liu, Jie Gao, Shuang Zhao, Hongshan Chen, Zhengrong Huang et al. · 2021 · British Journal of Pharmacology
PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation
Bo Xie, Xinyu Liu, Jie Yang, Jinke Cheng, Jianmin Gu, Song Xue · 2018 · BMC Cell Biology
SUMOylation in α-Synuclein Homeostasis and Pathology
Mor Savyon, Simone Engelender · 2020 · Frontiers in Aging Neuroscience
Role of neddylation in neurological development and diseases
Xin He, Ainong Zhu, Jianguo Feng, Xiaobin Wang · 2021 · Biotechnology and Applied Biochemistry
Mucin-Type O-GalNAc Glycosylation in Health and Disease
Ieva Bagdonaite, Emil M.H. Pallesen, Mathias Ingemann Nielsen, Eric Bennett, Hans Heugh Wandall · 2021 · Advances in experimental medicine and biology
Phosphoproteomics in translational research: a sarcoma perspective
Jonathan Christopher Noujaim, Leo S. Payne, Ian Robert Judson, Robin L. Jones, Paul H. Huang · 2016 · Annals of Oncology
Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus
Roberto Lande, Raffaella Palazzo, Nicolas Gestermann, Camilla Jandus, Mario Falchi, Francesca Spadaro, Valeria Riccieri, Eddie A. James, Alessia Butera, Monica Boirivant et al. · 2020 · Scientific Reports
Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia
Moua Yang, Wei Li, Calvin A. Harberg, Wenjing Chen, Hong Yue, Renan Barroso Ferreira, Sarah L. Wynia‐Smith, Kate S. Carroll, Jacek Zielonka, Robert C. Flaumenhaft et al. · 2020 · Blood Advances
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Andrew Fedoriw, Leilei Shi, Shane W. O’Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian S. Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams et al. · 2022 · Cancer Immunology Research
Autoantibodies to heterogeneous nuclear ribonucleoproteins
Roberto Felice Caporali, Serena Bugatti, E Bruschi, Lorenzo Cavagna, Carlomaurizio Montecucco · 2005 · Autoimmunity
A potential role for protein palmitoylation and zDHHC16 in DNA damage response
Na Cao, Jia-Kai Li, Yuqing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Jing Li, Jing Li · 2016 · BMC Molecular Biology
Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line
Mathias Ingemann Nielsen, Noortje de Haan, Weston Kightlinger, Zilu Ye, Sally Dabelsteen, Minyan Li, Michael C. Jewett, Ieva Bagdonaite, Sergey Y. Vakhrushev, Hans Heugh Wandall · 2022 · Nature Communications
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
Nevine A. Shalaby, Raheel Sayed, Qiao Zhang, Shane O. Scoggin, Susan Eliazer, Adrian Rothenfluh, Michael Buszczak · 2017 · Scientific Reports
EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation
Tie-Bo Zeng, Li Han, Nicholas Pierce, Gerd P. Pfeifer, Piroska E. Szabó · 2019 · Proceedings of the National Academy of Sciences
Lysine glutarylation in human sperm is associated with progressive motility
Yi-min Cheng, Xiao-nian Hu, Zhen Peng, Ting-ting Pan, Fang Wang, Houyang Chen, Wenqiong Chen, Yu Zhang, Xuhui Zeng, Tao Luo · 2019 · Human Reproduction
PRMT5 regulates T cell interferon response and is a target for acute graft-versus-host disease
Katiri Jenna Snyder, Nina C. Zitzer, Yandi Gao, Hannah Kyung Choe, Natalie E. Sell, Lotus M Neidemire-Colley, Anora Ignaci, Charuta Kale, Raymond D. Devine, Maria G. Abad et al. · 2020 · JCI Insight
Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation
Mattéa J. Finelli · 2020 · Frontiers in Aging Neuroscience
Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation
Jing Xu, Tao Yu, Enrica Caterina Pietronigro, Jia Yuan, Jessica Arioli, Yifei Pei, Xuan Luo, Jialin Ye, Gabriela Constantin, Chaoming Mao et al. · 2020 · PLoS Biology
SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells
Xia Li, Yue Jiang, Xuehong Zhang, Xinran Wang, Ran Wei, Kang Qin, Ying Lu · 2021 · Cell Death and Disease
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
Young-Mee Kim, Sarah Krantz, Ankit Jambusaria, Péter T. Tóth, Hyung‐Geun Moon, Isuru Gunarathna, Gye Young Park, Jalees Rehman · 2021 · Nature Communications
ER reductive stress caused by Ero1α S-nitrosation accelerates senescence
Xinhua Qiao, Yingmin Zhang, Aojun Ye, Yini Zhang, Ting Xie, Zhenyu Lv, Shi Chang, Dongli Wu, Boyu Chu, Xun Wu et al. · 2022 · Free Radical Biology and Medicine
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
Adam Hage, Preeti Bharaj, Sarah van Tol, María I. Giraldo, María González-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen et al. · 2022 · Cell Reports
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression
Feng Ru Tang, Chao Yang, Fengping Li, Donghu Yu, Zhiyong Pan, Xinghuan Wang, Zhiqiang Li · 2022 · Molecular Therapy — Nucleic Acids
Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects
Ru Yang, Yun Gao, Hui Li, Wei Chieh Huang, Dezhen Tu, Mengnan Yang, Xingqian Liu, Jau‐Shyong Hong, Hui‐Ming Gao · 2022 · Cell Reports
SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function
Lin Cong, Suresh B. Pakala, Kazufumi Ohshiro, Da‐Qiang Li, Rakesh Kumar · 2011 · Journal of Biological Chemistry
Sorafenib for the treatment of thyroid cancer: an updated review
Jolanta Krajewska, Daria Handkiewicz-Junak, Barbara Jarząb · 2015 · Expert Opinion on Pharmacotherapy
PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells
Martin Puhr, Julia Hoefer, Hannes Neuwirt, Iris Elisabeth Eder, Johann Kern, Georg Schäfer, Stephan Geley, Isabel Maria Heidegger, Helmut Klocker, Zoran Čulig · 2014 · Oncotarget
The SUMO pathway in pancreatic cancer: insights and inhibition
Christian Schneeweis, Zonera Hassan, Markus Schick, Ulrich Bernd Keller, Günter Schneider · 2020 · British Journal of Cancer
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING
Natalia Zamorano Cuervo, Audray Fortin, Elise Caron, Stéfany Chartier, Nathalie Grandvaux · 2021 · Science Signaling
Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models
Shanshan Deng, Antonio Solinas, Diego Francesco Calvisi · 2021 · Frontiers in Oncology
The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3
Hanjiang Luo, Caixia Peng, Xiaofeng Xu, Yuntao Peng, Fang Shi, Qinghua Li, Jianghui Dong, Min Chen · 2022 · Molecular Neurobiology
Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation
Rajnish Kumar, Michael Tuen, Hualin Li, Doris B. Tse, Catarina E. Hioe · 2011 · Vaccine
HDAC3 Is a Master Regulator of mTEC Development
Yael Goldfarb, Noam Kadouri, Ben Zion Levi, Asaf Sela, Yonatan Herzig, Ronald Cohen, Anthony Neil Hollenberg, Jakub Abramson · 2016 · Cell Reports
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling
Huifeng Wang, Bing Xu, Xiaoqian Zhang, Yabing Zheng, Yan Zhao, Xiaotian Chang · 2016 · Cancer Cell International
In utero exposure to PM2.5 during gestation caused adult cardiac hypertrophy through histone acetylation modification
Xiaoqi Wu, Bo Pan, Lingjuan Liu, Weian Zhao, Jing Zhu, Xupei Huang, Jie Tian · 2018 · Journal of Cellular Biochemistry
p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1
Xuesong Han, Xudong Xiang, Hongying Yang, Hongping Zhang, Shuang Liang, Jie Wei, Jing Yu · 2020 · Analytical Cellular Pathology
Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis
Binhui Zhou, Wen‐Yi Yang, Wushan Li, Le D. He, Liaoxun Lu, Lichen Zhang, Zhuangzhuang Liu, Ying Wang, Tianzhu Chao, Rong Huang et al. · 2021 · Frontiers in Immunology
Fostamatinib: A Review in Chronic Immune Thrombocytopenia
Julia Paik · 2021 · Drugs
Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
Zeyu Yin, Yuanming Zou, Dong Wang, Xinyue Huang, Shengjun Xiong, Liu Cao, Ying Zhang, Yingxian Sun, Naijin Zhang · 2022 · Cell Death Discovery
KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy
Lihong Lu, Xue Li, Ziwen Zhong, Wenchang Zhou, Di Zhou, Minmin Zhu, Changhong Miao · 2021 · International Journal of Biological Sciences
When S -Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases
Costanza Montagna, Claudia Cirotti, Salvatore Rizza, Giuseppe Filomeni · 2020 · Antioxidants and Redox Signaling
Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing
Haina Zhang, Ying Dai, Chunhong Zhang, Martin Omondi Alfred, Arunima Ghosh, Ipshita Khanra, Manas Chakraborty, Xuben Yu, Jing Lu Liang · 2020 · Biogerontology
SIRT6‑specific inhibitor OSS‑128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress
Yibo Huang, Junkai Zhang, Dongdong Xu, Peng Yu, Yuan Jin, Lei Zhang · 2021 · Molecular Medicine Reports
A comprehensive review of BET-targeting PROTACs for cancer therapy
Xiaoli Zhou, Fang Zhao, Yong-Tao Xu, Yuanyuan Guan, Tong Yu, Yizhe Zhang, Ying‐Chao Duan, Yuan Zhao · 2022 · Bioorganic & Medicinal Chemistry
Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
Milan Raška, Lýdie Czerneková, Zina Moldoveanu, Kateřina Zachová, Matt C. Elliott, Zdeněk Novák, Stacy D. Hall, Michael Höelscher, Leonard Maboko, Rhubell Brown et al. · 2014 · AIDS Research and Therapy
Cabozantinib for the treatment of progressive metastatic medullary thyroid cancer
Jolanta Krajewska, Tomasz Olczyk, Barbara Jarząb · 2015 · Expert Review of Clinical Pharmacology
Type III or allosteric kinase inhibitors for the treatment of non-small cell lung cancer
Morena Fasano, Carminia Maria Della Corte, Raffaele Califano, Annalisa Capuano, Teresa Troiani, Erika Martinelli, Fortunato Ciardiello, Floriana Morgillo · 2014 · Expert Opinion on Investigational Drugs
IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling
Jill M. Marinis, Jessica E. Hutti, Craig R. Homer, Brian A. Cobb, Lewis C. Cantley, Christine McDonald, Derek W. Abbott · 2012 · Molecular and Cellular Biology
Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations
Ayelet Avin, Maayan Levy, Ziv Porat, Jakub Abramson · 2017 · Nature Communications
Author Correction: Functions and mechanisms of non-histone protein acetylation
Takeo Narita, Brian Tate Weinert, Chunaram Choudhary · 2019 · Nature Reviews Molecular Cell Biology
Quantitative and Site-Specific Chemoproteomic Profiling of Protein O-GlcNAcylation in the Cell Cycle
Jialin Liu, Yi Hao, Yanwen He, Xiang Li, De‐en Sun, Yang Zhang, Pengyuan Yang, Xing Chen · 2021 · ACS Chemical Biology
SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage
Xiaoqing Fan, Suling Sun, Haoran Yang, Huihui Ma, Chenggang Zhao, Wanxiang Niu, Junqi Fan, Zhiyou Fang, Xueran Chen · 2022 · International Journal of Radiation Oncology*Biology*Physics
Association Between Neddylation and Immune Response
Jiali Zhu, Feng Chu, Meirong Zhang, Wenhuan Sun, Fangfang Zhou · 2022 · Frontiers in Cell and Developmental Biology
Dyrk1A phosphorylates parkin at Ser‐131 and negatively regulates its ubiquitin E3 ligase activity
Eunju Im, Kwang Chul Chung · 2015 · Journal of Neurochemistry
Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells
Joel Basken, Scott A. Stuart, Andrew J. Kavran, Thomas Lee, Christopher C. Ebmeier, William M. Old, Natalie G. Ahn · 2017 · Molecular & Cellular Proteomics
Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin
Sidong Cai, Panxia Wang, Tingting Xie, Zhenzhen Li, Jingyan Li, Rui Lan, Yan-qing Ding, Jing Lü, Jiantao Ye, Junjian Wang et al. · 2020 · Pharmacological Research
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
Yen‐Chen Liu, Wei‐Lun Hsu, Yun‐Li Ma, Eminy H.Y. Lee · 2020 · Molecular Therapy
Chemical Catalysis Intervening to Histone Epigenetics
Tamiko Nozaki, Motomu Kanai · 2021 · Accounts of Chemical Research
The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction
Qingfeng Li, Hongzhuang Peng, Huahao Fan, X Zou, Qian Liu, Yao Zhang, Hong Xu, Y Chu, Chenshiyu Wang, Kasirajan Ayyanathan et al. · 2015 · Cell Death and Differentiation
Mediator Influences Telomeric Silencing and Cellular Life Span
Xuefeng Zhu, Beidong Liu, Jonas O. P. Carlsten, Jenny Béve, Thomas Nyström, Lawrence C. Myers, Claes M. Gustafsson · 2011 · Molecular and Cellular Biology
Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies
Shuichiro Nakabo, Motomu Hashimoto, Shinji Ito, Moritoshi Furu, Hiromu Ito, Takao Fujii, Hajime Yoshifuji, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami et al. · 2017 · Lara D. Veeken
TRAF6 neddylation drives inflammatory arthritis by increasing NF-κB activation
Kewei Liu, Kaizhe Chen, Qian Zhang, Lianfang Zhang, Yufei Yan, Changjun Guo, Jin Qi, Kai Yang, Fei Wang, Ping Huang et al. · 2019 · Laboratory Investigation
PRMT1 promotes neuroblastoma cell survival through ATF5
Zhong-Yan Hua, Jeanne N. Hansen, Miao He, Shang‐Kun Dai, Yoonjung Choi, Melody D. Fulton, Sarah M. Lloyd, Marianna Szemes, Ji Sen, Han‐Fei Ding et al. · 2020 · Oncogenesis
PRMT5 Prevents Dilated Cardiomyopathy via Suppression of Protein O-GlcNAcylation
Zhenhua Li, Jingping Xu, Yao Song, Chong Xin, Lantao Liu, Ning Hou, Yan Teng, Xuan Cheng, Tianle Wang, Zhenyang Yu et al. · 2021 · Circulation Research
Auto-antibodies to post-translationally modified proteins in osteoarthritis
Xuanxiao Xie, Myrthe A. M. van Delft, Farag Shuweihdi, Sarah R. Kingsbury, Leendert Adrianus Trouw, Gina M. Doody, Philip G. Conaghan, Frédérique Ponchel · 2021 · Osteoarthritis and Cartilage