Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Qian, Xiao, Xina, Qiu, Yijie, Xu, Zhiqiang, Chen, Chunyu, Chong, Baochen, Zhao, Xinjun, Hai, Shan +3 more·2023·MedComm

DOI 10.1002/mco2.261

Cites (1,499)

Items 401–600 of 1,498

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Aleša Bricelj, Christian Steinebach, Robert D. Kuchta, Michael Gütschow, Izidor Sosič · 2021 · Frontiers in Chemistry
The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association
Abdollah Allahverdi, Renliang Yang, Nikolay Korolev, Yan-Ping Fan, Curt Alexander Davey, Chuan‐Fa Liu, Lars Nordenskiöld · 2010 · Nucleic Acids Research
Reducing acetylated tau is neuroprotective in brain injury
Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Koh, Yeojung, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Barker, Sarah, Miller, Emiko, Franke, Kathryn, Noterman, Maria F. et al. · 2021 · Cell
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
von Schimmelmann, Melanie, Feinberg, Philip A, Sullivan, Josefa M, Ku, Stacy M, Badimon, Ana, Duff, Mary Kaye, Wang, Zichen, Lachmann, Alexander, Dewell, Scott, Ma'ayan, Avi et al. · 2016 · Nature Neuroscience
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling
Kristin B. Runkle, Akriti Kharbanda, Ewa Stypulkowski, Xing-Jun Cao, Wei Wang, Benjamin Aaron Garcia, Eric S. Witze · 2016 · Molecular Cell
Post-translational myristoylation: Fat matters in cellular life and death
Dale D. O. Martin, Erwan Beauchamp, Luc G. Berthiaume · 2010 · Biochimie
Lysine benzoylation is a histone mark regulated by SIRT2
He Huang, Di Zhang, Yi Wang, Mathew Perez‐Neut, Zhen Hai Han, Yujun George Zheng, Quan Hao, Yingming Zhao · 2018 · Nature Communications
Methylation of the Retinoblastoma Tumor Suppressor by SMYD2
Louis Saddic, Lisandra E. West, Aaron Aslanian, John R. Yates, Seth M. Rubin, Or Gozani, Julien Sage · 2010 · Journal of Biological Chemistry
Kinase inhibitors and monoclonal antibodies in oncology: clinical implications
Helen Gharwan, Hunter Groninger · 2015 · Nature Reviews Clinical Oncology
Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma
Robert C. Kane, Ann T. Farrell, Rajanikanth Madabushi, Brian P. Booth, Somesh Chattopadhyay, Rajeshwari Sridhara, Robert L. Justice, Richard Pazdur · 2009 · The Oncologist
dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications
Kai‐Yao Huang, Tzong-Yi Lee, Hui-Ju Kao, Chen-Tse Ma, Chao-Chun Lee, Tsai-Hsuan Lin, Wen‐Chi Chang, Hsien‐Da Huang · 2018 · Nucleic Acids Research
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota
Hiroko Nagao‐Kitamoto, Jhansi L. Leslie, Sho Kitamoto, Chunsheng Jin, Kristina A. Thomsson, Merritt G. Gillilland, Peter Kuffa, Yoshiyuki Goto, Robert R. Jenq, Chiharu Ishii et al. · 2020 · Nature Medicine
RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage
Marco Gatti, Sabrina Pinato, Alessio Maiolica, Francesca Rocchio, Maria Giulia Prato, Ruedi H. Aebersold, Lorenza Penengo · 2015 · Cell Reports
“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
Yuxing Xia, Stefan Prokop, Benoit I. Giasson · 2021 · Molecular Neurodegeneration
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Róisín O’Flaherty, Tomonori Izumi, Yuka Mimura‐Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto et al. · 2017 · Protein & Cell
Mechanism and regulation of the Lys6-selective deubiquitinase USP30
Malte Gersch, Christina Gladkova, Alexander F. Schubert, Martin A. Michel, Sarah Maslen, David Komander · 2017 · Nature Structural & Molecular Biology
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor
Alexander A. Chumanevich, Corey P. Causey, Bryan Knuckley, Justin E. Jones, Deepak Poudyal, Alena P. Chumanevich, Tia Davis, Lydia E. Matesic, Paul R. Thompson, Lorne J. Hofseth · 2011 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Malonylation of GAPDH is an inflammatory signal in macrophages
Silvia Galván-Peña, Richard G. Carroll, Carla F. Newman, Elizabeth C. Hinchy, Eva M. Pålsson‐McDermott, Elektra Kantzari Robinson, Sergio Covarrubias, Alan J. Nadin, Andrew M. James, Moritz Haneklaus et al. · 2019 · Nature Communications
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation
Xuesen Zhang, Michael J. Bolt, Michael J. Guertin, Wei Chen, Sheng Zhang, Brian D. Cherrington, Daniel Joseph Slade, Christina J. Dreyton, Venkataraman Subramanian, Kevin L. Bicker et al. · 2012 · Proceedings of the National Academy of Sciences
Lenvatinib: Role in thyroid cancer and other solid tumors
Maria E. Cabanillas, Mouhammed Amir Habra · 2015 · Cancer Treatment Reviews
Protein carbamylation is a hallmark of aging
Laëtitia Gorisse, Christine Piétrement, Vincent Vuiblet, Christian E.H. Schmelzer, Martin Köhler, Laurent Duca, Laurent Debelle, Paul Fornés, Stéphane Jaisson, Philippe Gillery · 2015 · Proceedings of the National Academy of Sciences
Selective Deimination of Vimentin in Calcium Ionophore-Induced Apoptosis of Mouse Peritoneal Macrophages
Hiroaki Asaga, Michiyuki Yamada, Tatsuo Senshu · 1998 · Biochemical and Biophysical Research Communications
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
Yingying Tong, Dong Sheng Guo, Shuhai Lin, Jiazhen Liang, Dianqiang Yang, Chunmin Ma, Fei Shao, Min Li, Qiujing Yu, Yuhui Jiang et al. · 2021 · Molecular Cell
Activation mechanism of PINK1
Zhong Yan Gan, Sylvie Callegari, Simon A. Cobbold, Thomas R. Cotton, Michael J. Mlodzianoski, Alexander F. Schubert, Niall D. Geoghegan, Kelly L. Rogers, Andrew P. Leis, Grant Dewson et al. · 2021 · Nature
N‐terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects
Sylvia Varland, Camilla Osberg, Thomas Arnesen · 2015 · PROTEOMICS
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Matteo Spinelli, Salvatore Fusco, Marco Mainardi, Federico Scala, Francesca Natale, Rosita Lapenta, Andrea Mattera, Marco Rinaudo, Domenica Donatella Li Puma, Cristian Ripoli et al. · 2017 · Nature Communications
PTMD: A Database of Human Disease-Associated Post-Translational Modifications
Haodong Xu, Yongbo Wang, Shaofeng Lin, Wankun Deng, Di Peng, Qinghua Cui, Yu Xue · 2018 · Genomics Proteomics & Bioinformatics
Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update
Robert Jr. Roskoski · 2021 · Pharmacological Research
The Rheumatoid Arthritis-Associated Citrullinome
Ronak R. Tilvawala, Son Hong Nguyen, Aaron J. Maurais, Venkatesh V. Nemmara, Mitesh Nagar, Ari J. Salinger, Sunil Nagpal, Eranthie Weerapana, Paul R. Thompson · 2018 · Cell chemical biology
Beyond histone acetylation—writing and erasing histone acylations
Shuai Zhao, Xingrun Zhang, Haitao Li · 2018 · Current Opinion in Structural Biology
SENP3 is responsible for HIF‐1 transactivation under mild oxidative stress via p300 de‐SUMOylation
Chao Huang, Yan Yi Han, Yumei Wang, Xuxu Sun, Shan Yan, Edward T.H. Yeh, Yuying Chen, Hui Cang, Hui Li, Guiying Shi et al. · 2009 · The EMBO Journal
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer
Hongyi Liu, Yingying Liu, Fan Yang, Lin Zhang, Fanglin Zhang, Xin Hu, Zhimin Shao, Da‐Qiang Li · 2020 · Nucleic Acids Research
Histone propionylation is a mark of active chromatin
Adam Fiseha Kebede, Anna Nieborak, Lara Zorro Shahidian, Stéphanie Le Gras, Florian Martin Richter, Diana Aguilar‐Gómez, Marijke P. A. Baltissen, Gergő Mészáros, Helena de Fatima Magliarelli, Aaron Taudt et al. · 2017 · Nature Structural & Molecular Biology
Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress
Маргарита Е. Неганова, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev · 2020 · Seminars in Cancer Biology
Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
Xiangyuan Luo, Kongming Wu, Xingxing He · 2021 · Journal of Experimental & Clinical Cancer Research
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment
Wen Li, Feifei Li, Xia Zhang, Hui‐Kuan Lin, Chuan Shan Xu · 2021 · Signal Transduction and Targeted Therapy
Cellular pathways influenced by protein arginine methylation: Implications for cancer
Jian Xu, Stéphane Richard · 2021 · Molecular Cell
Structural Basis for Recruitment of Ubc12 by an E2 Binding Domain in NEDD8's E1
Danny T. C. Huang, Amir Paydar, Min Zhuang, Michael Brett Waddell, James M. Holton, Brenda Arlene Schulman · 2005 · Molecular Cell
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
Mikyoung Chang, Wei Jin, Jae‐Hoon Chang, Yichuan Xiao, George C. Brittain, Jiayi Yu, Xiaofei Zhou, Yi-Hong Wang, Xuhong Cheng, Pingwei Li et al. · 2011 · Nature Immunology
Nonreceptor Protein-Tyrosine Phosphatases in Immune Cell Signaling
Lily I. Pao, Karen Badour, Katherine Siminovitch, Benjamin G. Neel · 2007 · Annual Review of Immunology
MAP4K Family Kinases in Immunity and Inflammation
Huai‐Chia Chuang, Xiaohong Wang, Tse‐Hua Tan · 2015 · Advances in immunology
Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest
Helle D. Ulrich · 2005 · Trends in Cell Biology
The brain, sirtuins, and ageing
Akiko Satoh, Shin‐ichiro Imai, Leonard Guarente · 2017 · Nature reviews. Neuroscience
Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation
Thu Ha Truong, Kate S. Carroll · 2012 · Biochemistry
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis
Zhongwei Li, Diandian Wang, Jun Lü, Baiqu Huang, Yibo Wang, Meichen Dong, Dongmei Fan, Hongyuan Li, Yanyan Gao, Pingfu Hou et al. · 2020 · Cell Death and Differentiation
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation
Shuai Wang, Feng Xie, Feng Chu, Zhengkui Zhang, Bing Yang, Tong Dai, Liang Gao, Lin Wang, Li Ling, Junling Jia et al. · 2017 · Nature Immunology
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
Fulong Li, Jinping Liu, Ruoxuan Bao, Guoquan Yan, Xu Feng, Yanping Xu, Yiping Sun, Weili Yan, Zhi‐Qiang Ling, Yue Xiong et al. · 2018 · Nature Communications
Crizotinib in c-MET- or ROS1-positive NSCLC: results of the AcSé phase II trial
Denis Moro‐Sibilot, Nathalie Cozic, Maurice Pérol, Julien Mazières, Josiane Otto, Pierre Jean Souquet, Rastislav Bahleda, Marie Wislez, Gérard Zalcman, Sophie de Guibert et al. · 2019 · Annals of Oncology
Enhancer of zeste homolog 2 (EZH2) inhibitors
Nitya Gulati, Wendy Béguelin, Lisa G. Giulino-Roth · 2018 · Leukemia & lymphoma/Leukemia and lymphoma
Cysteine sulfenylation directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response
John M. Hourihan, Lorenza E. Moronetti Mazzeo, L. Paulette Fernández-Cárdenas, T. Blackwell · 2016 · Molecules and Cells
Nrf2: Molecular and epigenetic regulation during aging
Alejandro Silva‐Palacios, Marcos Ostolga-Chavarría, Cecilia Zazueta, Mina Königsberg · 2018 · Ageing Research Reviews
Ketone bodies in epilepsy
Melanie A. McNally, Adam L. Hartman · 2012 · Journal of Neurochemistry
Molecular mechanisms for protein kinase A-mediated modulation of immune function
Knut Martin Torgersen, Torkel Vang, Hilde Abrahamsen, Sheraz Yaqub, Kjetil Taskén · 2002 · Cellular Signalling
Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer
Lihui Li, Mingsong Wang, Guangyang Yu, Ping Chen, Hui Li, Dongping Wei, Ji Ye Zhu, Li Xie, Huixun Jia, Jie-Yi Shi et al. · 2014 · JNCI Journal of the National Cancer Institute
Immunometabolism in the development of rheumatoid arthritis
Weyand, Cornelia M., Goronzy, Jörg J. · 2020 · Immunological Reviews
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
Young Chan Kim, Sang Eun Lee, Somi K. Kim, Hyunduk Jang, Injoo Hwang, Sooryeonhwa Jin, Eun-Byeol Hong, Kyoung‐Soon Jang, Hyo-Soo Kim · 2019 · Nature Chemical Biology
Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis
Loretah Chibaya, Baktiar O. Karim, Hong Zhang, Stephen N. Jones · 2021 · Proceedings of the National Academy of Sciences
MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
Lai, Binbin, Lee, Ji-Eun, Jang, Younghoon, Wang, Lifeng, Peng, Weiqun, Ge, Kai · 2017 · Nucleic Acids Research
Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma
A. Benjamin Suttle, H A Ball, Mathiéu Molimard, Thomas E. Hutson, C Carpenter, Dilip Rajagopalan, Ying Lin, Suzanne Swann, Rafael G. Amado, L. N. Pandite · 2014 · British Journal of Cancer
Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges
Manuel M. Müller · 2017 · Biochemistry
DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane
Juan Wang, Jian-Wei Hao, Xu Wang, Huiling Guo, Hui-Hui Sun, Xiao-Ying Lai, Li-Ying Liu, Mingxia Zhu, Hao-Yan Wang, Yi-Fan Li et al. · 2019 · Cell Reports
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
Azhar Ali, Elena Levantini, Jun Ting Teo, Julian Goggi, John G. Clohessy, Chan Wu, Leilei Chen, Henry He Yang, Indira Krishnan, Olivier N. Kocher et al. · 2018 · EMBO Molecular Medicine
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts
Ying Zhang, Zhaoyong Liu, Xia Yang, Weiqing Lu, Yelong Chen, Youbin Lin, Jin Wang, Suxia Lin, Jing‐Ping Yun · 2020 · Theranostics
Targeting p300 Addiction in CBP -Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression
Hideaki Ogiwara, Mariko Sasaki, Takafumi Mitachi, Takahiro Oike, Saito Higuchi, Yuichi Tominaga, Takashi Kohno · 2015 · Cancer Discovery
Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors
Xiaotian Chang, Jinxiang Han · 2005 · Molecular Carcinogenesis
Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation
Gozde Colak, Olga Pougovkina, Lunzhi Dai, Minjia Tan, Heleen te Brinke, He Huang, Zhongyi Cheng, Jeong-Soon Park, Xuelian Wan, Xiaojing Liu et al. · 2015 · Molecular & Cellular Proteomics
Short-chain fatty acid, acylation and cardiovascular diseases
Xiaofeng Chen, Xiangqi Chen, Xiaoqiang Tang · 2020 · Clinical Science
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Patrick C. Bradshaw · 2021 · Antioxidants
The Relative Activities of the C2GnT1 and ST3Gal-I Glycosyltransferases Determine O-Glycan Structure and Expression of a Tumor-associated Epitope on MUC1
Martin Dalziel, Caroline Whitehouse, Ian McFarlane, Inka Brockhausen, Stephen Gschmeissner, Tilo Schwientek, Henrik Clausen, Joy Burchell, Joyce Taylor‐Papadimitriou · 2001 · Journal of Biological Chemistry
Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins
Gianluca Figlia, Philipp Willnow, Aurelio A. Teleman · 2020 · Developmental Cell
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
Xiao, Yichuan, Jin, Jin, Chang, Mikyoung, Chang, Jae-Hoon, Hu, Hongbo, Zhou, Xiaofei, Brittain, George C, Stansberg, Christine, Torkildsen, Øivind, Wang, Xiaodong et al. · 2013 · Nature Medicine
Protein N-Glycosylation, Protein Folding, and Protein Quality Control
Jürgen Roth, Christian Zuber, Sujin Park, Insook Jang, Yangsin Lee, Katarína Gaplovská-Kyselá, Valérie Le Fourn, Roger Santimaria, Bruno Guhl, Jin Won Cho · 2010 · Molecules and Cells
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Wei Wang, Yuxuan Zheng, Shuhui Sun, Wei Li, Moshi Song, Qianzhao Ji, Zeming Wu, Zunpeng Liu, Yanling Fan, Feifei Liu et al. · 2021 · Science Translational Medicine
Lens proteomics: the accumulation of crystallin modifications in the mouse lens with age.
Yoji Ueda, Melinda K. Duncan, Larry L. David · 2002 · PubMed
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
Atsuo T. Sasaki, Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, Lewis C. Cantley · 2011 · Science Signaling
Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction
Jeremy Martin Henley, Tim J. Craig, Kevin A. Wilkinson · 2014 · Physiological Reviews
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development
Brooke N. Benner, Logan Good, Dionisia Marie Quiroga, Thomas E Schultz, Mahmoud Attia Mohamed Kassem, William Edgar Carson, Mathew Amprayil Cherian, Sagar D. Sardesai, Robert Wesolowski · 2020 · Drug Design Development and Therapy
A Periplasmic Reducing System Protects Single Cysteine Residues from Oxidation
Matthieu Depuydt, Stephen E. Leonard, Didier Vertommen, Katleen Denoncin, Pierre Morsomme, Khadija Wahni, Joris Messens, Kate S. Carroll, Jean‐François Collet · 2009 · Science
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking
Wei-Chien Yuan, Yu-Ru Lee, Shu‐Yu Lin, Li-Ying Chang, Yen Pei Tan, Chin‐Chun Hung, Jean‐Cheng Kuo, Cheng‐Hsin Liu, Mei-Yao Lin, Ming Xu et al. · 2014 · Molecular Cell
Sumo-1 Function Is Dispensable in Normal Mouse Development
Fuping Zhang, Laura Mikkonen, Jorma Toppari, Jorma J. Palvimo, Irma Thesleff, Olli A. Jänne · 2008 · Molecular and Cellular Biology
Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results
John C. Byrd, William G. Wierda, Anna Schuh, Stephen Devereux, Jorge M Chaves, Jennifer R. Brown, Peter Hillmen, Peter Martin, Farrukh Tauseef Awan, Deborah Marie Stephens et al. · 2019 · Blood
Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
Okabe, Jun, Orlowski, Christian, Balcerczyk, Aneta, Tikellis, Chris, Thomas, Merlin C., Cooper, Mark E., El-Osta, Assam · 2012 · Circulation Research
Myristoylation: An Important Protein Modification in the Immune Response
Daniel Ikenna Udenwobele, Ruey‐Chyi Su, Sara Victoria Good, Terry Blake Ball, Shailly Varma Shrivastav, Anuraag Shrivastav · 2017 · Frontiers in Immunology
Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch
Daniel Panne, Sarah M. McWhirter, Tom Maniatis, Stephen C. Harrison · 2007 · Journal of Biological Chemistry
Molecular Substrates of Altered Axonal Growth and Brain Connectivity in a Mouse Model of Schizophrenia
Mukai, Jun, Tamura, Makoto, Fénelon, Karine, Rosen, Andrew M., Spellman, Timothy J., Kang, Rujun, MacDermott, Amy B., Karayiorgou, Maria, Gordon, Joshua A., Gogos, Joseph A. · 2015 · Neuron
The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Peleg, Shahaf, Feller, Christian, Ladurner, Andreas G., Imhof, Axel · 2016 · Trends in Biochemical Sciences
Phosphoproteomics in cancer
Harsha Gowda, Akhilesh Pandey · 2010 · Molecular Oncology
Structural basis for redox regulation of Yap1 transcription factor localization
Matthew J. A. Wood, Gisela Storz, Nico Tjandra · 2004 · Nature
Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus
Francesco Paneni, Sarah Costantino, Rodolfo Battista, Lorenzo Castello, Giuliana Capretti, Sergio Chiandotto, Giuseppe Scavone, Angelo Villano, Dario Pitocco, Gaetano Antonio Lanza et al. · 2014 · Circulation Cardiovascular Genetics
14-3-3 and FHA Domains Mediate Phosphoprotein Interactions
David Chevalier, Erin R. Morris, John C. Walker · 2008 · Annual Review of Plant Biology
Elucidating Human Phosphatase-Substrate Networks
Xun Li, Matthias Wilmanns, Janet M. Thornton, Maja Köhn · 2013 · Science Signaling
Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis
Peter Charles Taylor · 2018 · Lara D. Veeken
Peptidylarginine deiminase 4 and citrullination in health and disease
Consuelo Anzilotti, Federico Pratesi, Cristina Tommasi, Paola Migliorini · 2009 · Autoimmunity Reviews
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5
Xing Feng, Heng Zhang, Ling‐bing Meng, Huiwen Song, Qingxin Zhou, Chao Qu, Pan Zhao, Qinghua Li, Chang Zou, Xing Liu et al. · 2020 · Autophagy
Monoubiquitylation of α-Synuclein by Seven in Absentia Homolog (SIAH) Promotes Its Aggregation in Dopaminergic Cells
Ruth Rott, Raymonde Szargel, Joseph Haskin, Vered Shani, Alla Shainskaya, Irena Manov, Esti Liani, Eyal Avraham, Simone Engelender · 2007 · Journal of Biological Chemistry
Everolimus for subependymal giant cell astrocytoma: 5‐year final analysis
David Neal Franz, Karen D. Agricola, Maxwell Mays, Cindy Tudor, Marguerite M. Caré, Katherine D. Holland‐Bouley, Noah C. Berkowitz, Sara Miao, Séverine Peyrard, Darcy A. Krueger · 2015 · Annals of Neurology
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis
Erika Darrah, Antony Rosen, Jon T. Giles, Felipe Andrade · 2011 · Annals of the Rheumatic Diseases
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
Xun Shangguan, Jianli He, Zehua Ma, Weiwei Zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Zhixiang Xin, Quan Zheng et al. · 2021 · Nature Communications
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism
Sandra Nitsch, Lara Zorro Shahidian, Robert Schneider · 2021 · EMBO Reports
Nilotinib: A second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia
DeRemer, David L., Ustun, Celalettin, Natarajan, Kavita · 2008 · Clinical Therapeutics
An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation
Jie Zhang, Zhiwei Ye, Shweta Singh, Danyelle M. Townsend, Kenneth D. Tew · 2018 · Free Radical Biology and Medicine
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts
Tushar Damodar Bhagat, Dagny Von Ahrens, Meelad M. Dawlaty, Yiyu Zou, Joelle Baddour, Abhinav Achreja, Hongyun Zhao, Lifeng Yang, Brijesh Patel, Changsoo Kwak et al. · 2019 · eLife
Role of Protein Glycosylation in Host-Pathogen Interaction
Borong Lin, Xue Qing, Jinling Liao, Kan Zhuo · 2020 · Cells
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation
Belinda Mei Tze Ling, Narendra Bharathy, Teng‐Kai Chung, Wai Kay Kok, SiDe Li, Yong Hua Tan, Vinay Kumar Rao, Suma Gopinadhan, Vittorio Sartorelli, Martin J. Walsh et al. · 2012 · Proceedings of the National Academy of Sciences
The Mechanistic Impact of N-Glycosylation on Stability, Pharmacokinetics, and Immunogenicity of Therapeutic Proteins
Qun Zhou, Huawei Qiu · 2018 · Journal of Pharmaceutical Sciences
Sorafenib: a clinical and pharmacologic review
Iyer, Renuka, Fetterly, Gerald, Lugade, Amit, Thanavala, Yasmin · 2010 · Expert Opinion on Pharmacotherapy
Ubiquitination of -synuclein by Siah-1 promotes -synuclein aggregation and apoptotic cell death
J. T. Lee, Tiffany C. Wheeler, Lian Li, Lih‐Shen Chin · 2007 · Human Molecular Genetics
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
Guo, Xing, Wang, Xiaorong, Wang, Zhiping, Banerjee, Sourav, Yang, Jing, Huang, Lan, Dixon, Jack E. · 2016 · Nature Cell Biology
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Zheng, Yan, Liu, Aiyi, Wang, Zi-Jun, Cao, Qing, Wang, Wei, Lin, Lin, Ma, Kaijie, Zhang, Freddy, Wei, Jing, Matas, Emmanuel et al. · 2019 · Brain
Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity
Sungmin Song, Soyoung Kim, Yeon‐Mi Hong, Dong‐Gyu Jo, Joo‐Yong Lee, Sang Mi Shim, Chul‐Woong Chung, Soo Jung Seo, Yung Joon Yoo, Jae‐Young Koh et al. · 2003 · Molecular Cell
Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3
Lai Wei, David Kung‐Chun Chiu, Felice Ho‐Ching Tsang, Cheuk‐Ting Law, Carol Lai‐Hung Cheng, Sandy Leung–Kuen Au, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Chun‐Ming Wong, Chun‐Ming Wong · 2017 · Journal of Hepatology
High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome
Hassan, Ahmed M., Mancano, Giulia, Kashofer, Karl, Fröhlich, Esther E., Matak, Andrija, Mayerhofer, Raphaela, Reichmann, Florian, Olivares, Marta, Neyrinck, Audrey M., Delzenne, Nathalie M. et al. · 2019 · Nutritional Neuroscience
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
Hongfa Xu, Hao Wang, Wei Zhao, Sirui Fu, Yong Li, Wenjun Ni, Yongjie Xin, Wei Li, Chenzi Yang, Yanyan Bai et al. · 2020 · Theranostics
Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis
Guang Yang, Ying Yuan, Hongfeng Yuan, Jiapei Wang, Haolin Yun, Yu Geng, Man Zhao, Linhan Li, Yejing Weng, Zixian Liu et al. · 2020 · EMBO Reports
Global functions of O‐glycosylation: promises and challenges in O‐glycobiology
Hans Heugh Wandall, Mathias Ingemann Nielsen, Sarah King‐Smith, Noortje de Haan, Ieva Bagdonaite · 2021 · FEBS Journal
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting
Wei Liu, Lei Xie, Yao-Hui He, Zhi-Yong Wu, Lu-Xin Liu, Xuefeng Bai, Dan-Xia Deng, Xiu‐E Xu, Lian-Di Liao, Wan Lin et al. · 2021 · Nature Communications
Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
Florian Rudolf Fritzsche, Wilko Weichert, A.-E. Roske, Volker Gekeler, Thomas L. Beckers, Carsten Stephan, Klaus Jung, Katharina Scholmann, Carsten Denkert, Manfred Dietel et al. · 2008 · BMC Cancer
Cellular consequences of arginine methylation
Benjamin M. Lorton, David Shechter · 2019 · Cellular and Molecular Life Sciences
Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
Xiucong Bao, Zheng Liu, Wei Zhang, Kornelia Gladysz, Yi Man Eva Fung, Gaofei Tian, Ying Xiong, Jason W.H. Wong, Karen Wing Yee Yuen, Xiang Li · 2019 · Molecular Cell
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Dae‐Sung Hwangbo, Hye‐Yeon Lee, Leen Suleiman Abozaid, Kyung‐Jin Min · 2020 · Nutrients
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
Ying Qin, Qi Li, Wenbo Liang, Rongzhen Yan, Liqe Tong, Mu-Tian Jia, Chunyuan Zhao, Wei Zhao · 2021 · Nature Communications
Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence
Sen, Payel, Lan, Yemin, Li, Catherine Y., Sidoli, Simone, Donahue, Greg, Dou, Zhixun, Frederick, Brian, Chen, Qijun, Luense, Lacey J., Garcia, Benjamin A. et al. · 2019 · Molecular Cell
Modular evolution of phosphorylation-based signalling systems
Jing Jin, Tony J. Pawson · 2012 · Philosophical Transactions of the Royal Society B Biological Sciences
The ubiquitin–proteasome system in kidney physiology and disease
Catherine Meyer‐Schwesinger · 2019 · Nature Reviews Nephrology
Role of Nitric Oxide in Insulin Secretion and Glucose Metabolism
Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi · 2019 · Trends in Endocrinology and Metabolism
Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?
Simin Qi, Gang Cheng, Xiangdong Cheng, Zhiyuan Xu, Beihua Xu, Weidong Zhang, Jiang‐Jiang Qin · 2020 · Frontiers in Cell and Developmental Biology
Redox changes in obesity, metabolic syndrome, and diabetes
Bato Korać, Andjelika Kalezic, Vanja Pekovic‐Vaughan, Aleksandra Korać, Aleksandra Janković · 2021 · Redox Biology
Protein Carbamylation Renders High-Density Lipoprotein Dysfunctional
Michael Holzer, Martin Gauster, Thomas Pfeifer, Christian Wadsack, Guenter Fauler, Philipp Stiegler, Harald C. Köfeler, Eckhard Beubler, Rufina Schuligoi, Ákos Heinemann et al. · 2011 · Antioxidants and Redox Signaling
Carbamylation-Derived Products: Bioactive Compounds and Potential Biomarkers in Chronic Renal Failure and Atherosclerosis
Stéphane Jaisson, Christine Piétrement, Philippe Gillery · 2011 · Clinical Chemistry
Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis
Ryan S. Green, Erica Lyn Stone, Mari Tenno, Eero Lehtonen, Marilyn G. Farquhar, Jamey D. Marth · 2007 · Immunity
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation
Zhenke Wen, Ke Jin, Yi Shen, Zhen Yang, Yinyin Li, Bowen Wu, Lü Tian, Stanford Shoor, Niall E. Roche, Jörg J. Goronzy et al. · 2019 · Nature Immunology
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D. Webster, Hai Ngu, Christopher M. Rose, Donald S. Kirkpatrick, Zora D. Modrusan, Ying-Jiun Jasmine Chen, Debra L. Dugger et al. · 2020 · Cell
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ
Nikolay Burnaevskiy, Thomas G. Fox, Daniel A. Plymire, James M. Ertelt, Bethany A. Weigele, Andrey S. Selyunin, Sing Sing Way, Steven M. Patrie, Neal M. Alto · 2013 · Nature
Phosphatidylethanolamine is the donor of the ethanolamine residue linking a glycosylphosphatidylinositol anchor to protein.
Anant K. Menon, Victoria L. Stevens · 1992 · Journal of Biological Chemistry
Histone lysine crotonylation during acute kidney injury in mice
Olga Ruiz‐Andrés, María Dolores Sánchez-Niño, Pablo Cannata‐Ortiz, Marta Ruiz‐Ortega, Jesús Egido, Alberto Ortíz, Ana Belen Sanz · 2016 · Disease Models & Mechanisms
Cyclin E in normal physiology and disease states
Chen Chu, Yan Geng, Yu Zhou, Piotr Siciński · 2021 · Trends in Cell Biology
Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3
Evgenij Evdokimov, Prashant Sharma, Stephen J. Lockett, Margaret Lualdi, Michael R. Kuehn · 2008 · Journal of Cell Science
Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism
Andrew Advani, Qingling Huang, Kerri Thai, Suzanne L. Advani, Kathryn White, Darren J. Kelly, Darren A. Yuen, Kim Alexander Connelly, Philip A. Marsden, Richard E. Gilbert · 2011 · American Journal Of Pathology
Crosstalk between phosphorylation and O‐Glc NA cylation: friend or foe
Saar A. M. van der Laarse, Aneika C. Leney, Albert J. R. Heck · 2018 · FEBS Journal
The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
Weigang Liu, Xun Tang, Xuehong Qi, Xue Fu, Shantwana Ghimire, Rui Ma, Shigui Li, Ning Zhang, Huaijun Si · 2020 · International Journal of Molecular Sciences
Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
M. Markofski, J. Dickinson, M. Drummond, C. Fry, S. Fujita, D. Gundermann, E. Glynn, K. Jennings, D. Paddon-Jones, P. Reidy et al. · 2015 · Experimental Gerontology
Targeting E3 Ubiquitin Ligases for Cancer Therapy
Yi Sun · 2003 · Cancer Biology & Therapy
Discovering the landscape of protein modifications
E. Keith Keenan, Derek K. Zachman, Matthew D. Hirschey · 2021 · Molecular Cell
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies
Beatrice Greco, Valeria Malacarne, Federica De Girardi, Giulia Maria Scotti, Francesco Manfredi, Elia Angelino, Camilla Sirini, Barbara Camisa, Laura Falcone, Marta Angiola Moresco et al. · 2022 · Science Translational Medicine
Potential roles of N-glycosylation in cell adhesion
Jianguo Gu, Tomoya Isaji, Qingsong Xu, Yoshinobu Kariya, Wei Gu, Tomohiko Fukuda, Yuguang Du · 2012 · Glycoconjugate Journal
Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism
John A. Smestad, Luke N. Erber, Yue Chen, Louis James Maher · 2018 · iScience
Histone Acetyltransferase Activity of p300 Is Required for the Promotion of Left Ventricular Remodeling After Myocardial Infarction in Adult Mice In Vivo
Shoichi Miyamoto, Teruhisa Kawamura, Tatsuya Morimoto, Koh Ono, Hiromichi Wada, Yosuke Kawase, Akira Matsumori, Ryosuke Nishio, Toru Kita, Koji Hasegawa · 2006 · Circulation
Uncovering post-translational modification-associated protein–protein interactions
Wang, Shu, Osgood, Arianna O., Chatterjee, Abhishek · 2022 · Current Opinion in Structural Biology
USP4 inhibits p53 through deubiquitinating and stabilizing ARF‐BP1
Xinna Zhang, Franklin G. Berger, Jianhua Yang, Xiongbin Lu · 2011 · The EMBO Journal
Protein kinase C in the immune system: from signalling to chromatin regulation
Pek Siew Lim, Christopher R. Sutton, Sudha Rao · 2015 · Immunology
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance
Lonskaya, Irina, Hebron, Michaeline L., Desforges, Nicole M., Schachter, Joel B., Moussa, Charbel E-H · 2014 · Journal of Molecular Medicine
Overexpression and Ribozyme-mediated Targeting of Transcriptional Coactivators CREB-binding Protein and p300 Revealed Their Indispensable Roles in Adipocyte Differentiation through the Regulation of Peroxisome Proliferator-activated Receptor γ
Nobuyuki Takahashi, Teruo Kawada, Takayuki Yamamoto, Tsuyoshi Goto, Aki Taimatsu, Naohito Aoki, Hiroaki Kawasaki, Kazunari Taira, Kazunari K. Yokoyama, Yasutomi Kamei et al. · 2002 · Journal of Biological Chemistry
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons
Monica G. Boselli, Byung‐Hoon Lee, Jessica Robert, Miguel A. Prado, Sang‐Won Min, Chialin Cheng, M. Catarina Silva, Changhyun Seong, Suzanne Elsasser, Ketki M. Hatle et al. · 2017 · Journal of Biological Chemistry
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
He Huang, Zhouqing Luo, Shankang Qi, Jing Li Huang, Peng Xu, Xiuxuan Wang, Li Ping Gao, Fangyi Li, Jian Wang, Wenhui Zhao et al. · 2017 · Cell Research
Destabilization of Fatty Acid Synthase by Acetylation Inhibits <i>De Novo</i> Lipogenesis and Tumor Cell Growth
Lin, Huai-Peng, Cheng, Zhou-Li, He, Ruo-Yu, Song, Lei, Tian, Meng-Xin, Zhou, Li-Sha, Groh, Beezly S., Liu, Wei-Ren, Ji, Min-Biao, Ding, Chen et al. · 2016 · Cancer Research
Ubiquitin Makes Its Mark on Immune Regulation
Barbara A. Malynn, Averil I. Ma · 2010 · Immunity
p53 β-hydroxybutyrylation attenuates p53 activity
Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han, Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong et al. · 2019 · Cell Death and Disease
Histone citrullination: a new target for tumors
Dongwei Zhu, Yue Zhang, Shengjun Wang · 2021 · Molecular Cancer
PSD-95 protects synapses from β-amyloid
Dore, Kim, Carrico, Zachary, Alfonso, Stephanie, Marino, Marc, Koymans, Karin, Kessels, Helmut W., Malinow, Roberto · 2021 · Cell Reports
The role of O-glycosylation in human disease
Ana Magalhães, Henrique O. Duarte, Celso Albuquerque Reis · 2021 · Molecular Aspects of Medicine
Histone Deacetylase 9 Is a Negative Regulator of Adipogenic Differentiation
Tapan K. Chatterjee, Gila Idelman, Victor Blanco, Andra L. Blomkalns, Mark Piegore, Daniel S. Weintraub, Santosh Kumar, Srinivas Rajsheker, David R. Manka, Steven M. Rudich et al. · 2011 · Journal of Biological Chemistry
The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity
François‐Michel Boisvert, Alexandre Rhie, Stéphane Richard, Aidan J. Doherty · 2005 · Cell Cycle
Identification and Characterization of Propionylation at Histone H3 Lysine 23 in Mammalian Cells
Bo Liu, Yi-Hui Lin, Agus Darwanto, Xuehui Song, Guoliang Xu, Kangling Zhang · 2009 · Journal of Biological Chemistry
Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development
Shang‐Kun Dai, Pei-Pei Liu, Xiao Li, Lin‐Fei Jiao, Zhao‐Qian Teng, Chang‐Mei Liu · 2022 · Development
Protein carbamylation and cardiovascular disease
Frederik Hendrik Verbrugge, W.H. Wilson Tang, Stanley L. Hazen · 2015 · Kidney International
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection
Christopher Schliehe, Elizabeth K. Flynn, Bojan Vilagos, Udochuku Richson, Savitha Swaminathan, Berislav Bošnjak, Lisa Bauer, Richard K. Kandasamy, Isabel M Griesshammer, Lindsay Kosack et al. · 2014 · Nature Immunology
Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
Nicholas Giovannone, J. Liang, Aristotelis Antonopoulos, Jenna Geddes-Sweeney, Sandra L. King, Stephen M. Pochebit, Neil Bhattacharyya, G. S. Lee, Anne Dell, Hans R. Widlund et al. · 2018 · Nature Communications
Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis
Albert Salas‐Huetos, Leila Maghsoumi‐Norouzabad, Emma Rae James, Douglas T. Carrell, Kenneth Ivan Aston, Timothy G. Jenkins, Nerea Becerra‐Tomás, Ahmad Zare Javid, Reza Abed, Pedro Javier Torres et al. · 2020 · Obesity Reviews
Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases
Xavier Verhelst, Ana M. Dias, Jean‐Frédéric Colombel, Séverine Vermeire, Hans Van Vlierberghe, Nico Callewaert, Salomé S. Pinho · 2019 · Gastroenterology
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
Eric S. Lightcap, Pengfei Yu, Stephen Grossman, Keli Song, Mithun Khattar, Kristina Xega, Xingyue He, James M. Gavin, Hisashi Imaichi, James Garnsey et al. · 2021 · Science Translational Medicine
Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives
Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, Mirosław Soszyński, Luciano Pirola, Aneta Balcerczyk · 2022 · Cellular and Molecular Life Sciences
Protein post-translational modifications in the regulation of cancer hallmarks
Haiying Wang, Liqian Yang, Minghui Liu, Jianyuan Luo · 2022 · Cancer Gene Therapy
Methylation multiplicity and its clinical values in cancer
Xiaofeng Dai, Tiejun Ren, Yuxin Zhang, Nan Nan · 2021 · Expert Reviews in Molecular Medicine
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Ronald A. Albright, Paul R. Stabach, Wenxiang Cao, Dillon Kavanagh, Isabelle Mullen, Alexander A. Braddock, Mariel S. Covo, Martin Tehan, Guangxiao Yang, Zhiliang Cheng et al. · 2015 · Nature Communications
Protein palmitoylation and its pathophysiological relevance
Jiayu Jin, Xiuling Zhi, Xinhong Wang, Dan Meng · 2020 · Journal of Cellular Physiology
Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth
Changliang Shan, Shannon Elf, Quanjiang Ji, Hee‐Bum Kang, Lu Zhou, Taro Hitosugi, Lingtao Jin, Ruiting Lin, Liang Zhang, Jae Ho Seo et al. · 2014 · Molecular Cell
Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis
Leendert Adrianus Trouw, Michael Mähler · 2012 · Autoimmunity Reviews
Palmitoylation in Alzheimers disease and other neurodegenerative diseases
Eunsil Cho, Mikyoung Park · 2016 · Pharmacological Research
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration
Hal E. Broxmeyer · 2013 · The Journal of Experimental Medicine
The sulfinic acid switch in proteins
Claus Jacob, Andrea Lisa Holme, F.H. Fry · 2004 · Organic & Biomolecular Chemistry
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti, Thomas W. Hanigan, Ari J. Firestone, Anagha Inguva Sheth, Amanda M. Long, Nhi Ngo, Kenneth M. Lum, Cassandra L. Henry et al. · 2021 · Nature Chemical Biology
Interplay between chromatin marks in development and disease
Sanne Marlijn Janssen, Matthew C. Lorincz · 2021 · Nature Reviews Genetics
Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies
Jing Shi, Peter A. van Veelen, Michael Mähler, George M. C. Janssen, Jan Wouter Drijfhout, Tom W. J. Huizinga, René E. M. Toes, Leendert Adrianus Trouw · 2013 · Autoimmunity Reviews
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
Xiao-Xue Li, Zhijing Wang, Yu Zheng, Yun‐Feng Guan, Pengbo Yang, Xiang Chen, Cong Peng, Jianping He, Yuan-li Ai, Sheng-fu Wu et al. · 2018 · Molecular Cell
Direct cysteine sulfenylation drives activation of the Src kinase
David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying‐Wai Lam et al. · 2018 · Nature Communications
Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges
Xuelian Liu, Yu Zhang, Wei Li, Xin Zhou · 2022 · Frontiers in Cell and Developmental Biology
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
Ryan J. Lumpkin, Hongbo Gu, Yiying Zhu, Marilyn Leonard, Alla S. Ahmad, Karl R. Clauser, Jesse G. Meyer, Eric J. Bennett, Elizabeth A. Komives · 2017 · Nature Communications
Protein Acetylation and Histone Deacetylase Expression Associated with Malignant Breast Cancer Progression
Junko Suzuki, Yunn‐Yi Chen, Gary K. Scott, Sandy DeVries, Koei Chin, Christopher C. Benz, Frederic M. Waldman, E. Shelley Hwang · 2009 · Clinical Cancer Research
Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade
Jeongho Kwon, Eunhye Han, Chi‐Bao Bui, Woo‐Chul Shin, Jun Ho Lee, Sejeong Lee, Young‐Bong Choi, Ann–Hwee Lee, Kyong‐Hoon Lee, Chankyu Park et al. · 2012 · EMBO Reports
Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis
Satomi Yogosawa, Kiyotsugu Yoshida · 2018 · Cancer Science
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population
Yuanyuan Qu, Jinwen Feng, Xiaohui Wu, Lin Bai, Wenhao Xu, Lingli Zhu, Yang Liu, Fujiang Xu, Xuan Zhang, Guojian Yang et al. · 2022 · Nature Communications
Rewiring of the ubiquitinated proteome determines ageing in C. elegans
Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krüger, David Vı́lchez · 2021 · Nature
Cancer metabolism and tumor microenvironment: fostering each other?
Yiyuan Yuan, Huimin Li, Pu Wang, Leilei Chen, Dong Sheng Guo, Hongfei Jiang, Bo He, Siyuan Qin, Kui Wang, Na Li et al. · 2021 · Science China Life Sciences
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I
Marina Guerrin, Akihito Ishigami, Marie‐Claire Méchin, Rachida Nachat, Séverine Valmary‐Degano, Mireille Sebbag, Michel Simon, Tatsuo Senshu, Guy Serre · 2003 · Biochemical Journal
HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes
Jenny Y. Y. Ooi, Natasha Tuano, Haloom Rafehi, Xiao‐Ming Gao, Mark Ziemann, Xiao‐Jun Du, Assam El‐Osta · 2015 · Epigenetics
Quantitative Sub-Cellular Acyl-Coa Analysis Reveals Distinct Nuclear Regulation
Sophie Trefely, Katharina Huber, Joyce Liu, Michael Noji, Stephanie Stransky, Jay Prakash Singh, Mary T. Doan, Claudia D. Lovell, Eliana V. von Krusenstiern, Helen Jiang et al. · 2021 · Molecular Cell
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer
Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang, Shijun Lv, Yonghong Sun, Zhijun Liu, Yu Du, Zhenhai Yu · 2018 · Oncogene
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo
Mingming Zhang, Fang Cai, Shuting Zhang, Si Zhang, Weihong Song · 2014 · Scientific Reports
HDAC signaling in neuronal development and axon regeneration
Yongcheol Cho, Valeria Cavalli · 2014 · Current Opinion in Neurobiology
The role of SIRT1 in diabetic retinopathy
Hedyieh Karbasforooshan, Gholamreza Karimi · 2017 · Biomedicine & Pharmacotherapy