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Cited by 220Parkinson's Disease Mechanisms and TreatmentsPain Management and Opioid UseNeurological disorders and treatments

Prevalence of pain in Parkinson's disease: A systematic review using the modified QUADAS tool

Broen, Martijn P.G., Braaksma, Meriam M., Patijn, J., Weber, Wim E.J.·2012·Movement Disorders
DOI 10.1002/mds.24054
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Abstract

Pain has been studied more intensely as a symptom of Parkinson's disease (PD) in recent years. However, studies on the characteristics and prevalence of pain in PD have yielded conflicting results, prompting us to do a systematic review of the literature. A systematic review of the literature was conducted, using different databases. The last inclusion date was March 15, 2011. The modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool was used, which is especially designed for judging prevalence studies on their methodological quality. Only articles that met the predefined criteria were used in this review. We found 18 articles, of which only 8 met the methodological criteria. Prevalence frequency ranges from 40% to 85% with a mean of 67.6%. Pain is most frequently located in the lower limbs, with almost one-half of all PD patients complaining about musculoskeletal pain (46.4%). The pain fluctuates with on-off periods. Surprisingly, only 52.4% of PD patients with pain used analgesics, most often nonopioids. PD patients seem to be predisposed to develop pain and physicians should be aware of pain as a common feature of PD. As many as one-half of PD patients with pain may be missing out on a potentially useful treatment, and proper treatment could increase quality of life in PD patients.

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Crossref · 10.1002/mds.24054

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  • Dystonic, radicular and central neuropathic pain are less common in Parkinson's disease.

    “Dystonic, radicular and central neuropathic pain are less common (Broen et al. 2012).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Broen et al. 2012

  • Pain is reported by 40-85% of Parkinson's disease patients.

    “Pain is reported by 40-85% of patients (Broen et al. 2012).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Broen et al. 2012

  • Musculoskeletal pain is reported by almost half of Parkinson's disease patients.

    “Musculoskeletal pain is reported by almost half of the patients, but such pain is common in this age group and may not always be related to the PD.”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Broen et al. 2012

  • Musculoskeletal pain is common in this age group and may not always be related to Parkinson's disease.

    “Musculoskeletal pain is reported by almost half of the patients, but such pain is common in this age group and may not always be related to the PD.”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Broen et al. 2012

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Authors
Broen, M. P. G., Braaksma, M. M., Patijn, J., & Weber, W. E. J.
Affiliations
Maastricht University Medical Centre (NL)
Corresponding author
Broen, Martijn P.G.
ORCID
Weber, Wim E.J.
Venue
Movement Disorders
Publisher
Wiley
Published
2012-01-09
Volume
27
Issue
4
Pages
480-484
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
DOI
10.1002/mds.24054
OpenAlex
W2123037855
Cited by
220
References
47
Citations by year
2026: 8 · 2025: 18 · 2024: 24 · 2023: 18 · 2022: 18 · 2021: 16 · 2020: 27 · 2019: 19 · 2018: 16 · 2017: 14 · 2016: 18 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Movement Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Parkinson's disease, pain prevalence, musculoskeletal pain, lower limb pain, on-off phenomenon, analgesic use, non-opioid analgesics, quality of life
MeSH terms
Diagnostic Tests, Routine, Humans, Pain, Parkinson Disease, Review Literature as Topic, Prevalence

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