Intake of antioxidant vitamins and risk of Parkinson's disease
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Introduction: Oxidative stress is proposed to be one of the potential mechanisms leading to neurodegeneration in Parkinson's disease. However, previous epidemiologic studies investigating associations between antioxidant vitamins, such as vitamins E and C and carotenoids, and PD risk have produced inconsistent results. Objective: The objective of this work was to prospectively examine associations between intakes of antioxidant vitamins, including vitamins E and C and carotenoids, and PD risk. Methods: Cases were identified in two large cohorts: the Nurses' Health Study and the Health Professionals Follow‐up Study. Cohort members completed semiquantitative food frequency questionnaires every 4 years. Results: A total of 1036 PD cases were identified. Dietary intakes of vitamin E and carotenoids were not associated with PD risk; the multivariable‐adjusted relative risk comparing extreme intake quintiles were 0.93 (95% confidence interval: 0.75–1.14) and 0.97 (95% confidence interval: 0.69–1.37), respectively. Dietary vitamin C intake was significantly associated with reduced PD risk (relative risk: 0.81; 95% confidence interval: 0.65–1.01; p trend , 0.01); however, this result was not significant in a 4‐year lag analysis. For vitamins E and C, intake from foods and supplements combined were also unrelated to PD risk. Conclusions: Our results do not support the hypothesis that intake of antioxidant vitamins reduces the risk of PD. © 2016 International Parkinson and Movement Disorder Society
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Dietary intake of vitamin C has been connected with reduced risk of PD, however two large cohort studies did not confirm this expectation.
“Dietary intake of vitamin C has been connected with a reduced risk of PD, however, two large cohort studies did not confirm this expectation (Hughes et al. 2016).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Hughes et al. 2016
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- Authors
- Hughes, K. C., Gao, X., Kim, I. Y., Rimm, E. B., Wang, M., Weisskopf, M. G., Schwarzschild, M. A., & Ascherio, A.
- Affiliations
- Harvard University (US)
- Pennsylvania State University (US)
- Brigham and Women's Hospital (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Hughes, Katherine C.
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2016-10-27
- Volume
- 31
- Issue
- 12
- Pages
- 1909-1914
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC5154924
- OpenAlex
- W2543634467
- Cited by
- 110
- References
- 35
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 17 · 2022: 19 · 2021: 18 · 2020: 14 · 2019: 13 · 2018: 2 · 2017: 5
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- NIH (UM1 CA186107, UM1 CA167552, R01 NS061858)
- Department of Defense (W81XWH-14-0131)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- Parkinson's disease, antioxidant vitamins, vitamin E, vitamin C, carotenoids, dietary intake, oxidative stress, neurodegeneration, dietary supplements, Nurses' Health Study, Health Professionals Follow-up Study
- MeSH terms
- Adult, Aged, Antioxidants, Ascorbic Acid, Carotenoids, Female, Follow-Up Studies, Health Personnel, Humans, Male, Middle Aged, Nurses, Parkinson Disease, United States, Vitamin E
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