The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Flavonoids: Promising anticancer agents
Abstract
Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention is widely discussed. Compelling data from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and chemotherapy. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, antioxidation and reversal of multidrug resistance or a combination of these mechanisms. Based on these results, flavonoids may be promising anticancer agents. © 2003 Wiley Periodicals, Inc. Med Res Rev, 23, No. 4, 519–534, 2003
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[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Cited by
Flavonoids in Food and Their Health Benefits
YAO, L. H., JIANG, Y. M., SHI, J., TOM�S-BARBER�N, F. A., DATTA, N., SINGANUSONG, R., & CHEN, S. S. (2004) · Plant Foods for Human Nutrition · doi:10.1007/s11130-004-0049-7 · Cited by 1,545
Distribution and biological activities of the flavonoid luteolin
Lopez-Lazaro, M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709787001712 · Cited by 1,106
Huang, W.-Y., Cai, Y.-Z., & Zhang, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580903191585 · Cited by 1,009
Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering
Nabavi, S. M., Šamec, D., Tomczyk, M., Milella, L., Russo, D., Habtemariam, S., Suntar, I., Rastrelli, L., Daglia, M., Xiao, J., et al. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.005 · Cited by 664
Flavonoids as prospective compounds for anti-cancer therapy
Ravishankar, D., Rajora, A. K., Greco, F., & Osborn, H. M. I. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.10.004 · Cited by 572
Metadata
- Authors
- Ren, W., Qiao, Z., Wang, H., Zhu, L., & Zhang, L.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2003-04-15
- Volume
- 23
- Issue
- 4
- Pages
- 519-534
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2134979720
- Cited by
- 1,150
- References
- 3
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
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