Cited by 1,260Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS

Yang, Chung S, Landau, Janelle M, Huang, Mou-Tuan, Newmark, Harold L·2001·Annual Review of Nutrition

Abstract

Plants consumed by humans contain thousands of phenolic compounds. The effects of dietary polyphenols are of great current interest due to their antioxidative and possible anticarcinogenic activities. A popular belief is that dietary polyphenols are anticarcinogens because they are antioxidants, but direct evidence for this supposition is lacking. This chapter reviews the inhibition of tumorigenesis by phenolic acids and derivatives, tea and catechins, isoflavones and soy preparations, quercetin and other flavonoids, resveratrol, and lignans as well as the mechanisms involved based on studies in vivo and in vitro. Polyphenols may inhibit carcinogenesis by affecting the molecular events in the initiation, promotion, and progression stages. Isoflavones and lignans may influence tumor formation by affecting estrogen-related activities. The bioavailability of the dietary polyphenols is discussed extensively, because the tissue levels of the effective compounds determine the biological activity. Understanding the bioavailability and blood and tissue levels of polyphenols is also important in extrapolating results from studies in cell lines to animal models and humans. Epidemiological studies concerning polyphenol consumption and human cancer risk suggest the protective effects of certain food items and polyphenols, but more studies are needed for clear-cut conclusions. Perspectives on the application of dietary polyphenols for the prevention of human cancer and possible concerns on the consumption of excessive amounts of polyphenols are discussed.

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Crossref · 10.1146/annurev.nutr.21.1.381

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  • The aleuron layer of wheat bran contains phytoprotectants that have antioxidative and anti-inflammatory potential, and anticarcinogenic activities in rodent animal models of colon and skin cancer.

    “The aleuron layer of wheat bran contains a number of phytoprotectants (i.e., ferulic acid, alkylresorcinols, apigenin, lignans, and phytic acid), which have antioxidative and anti-inflammatory potential, and anticarcinogenic activities in rodent animal models of colon and skin cancer (56–59).”

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Authors
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L.
Affiliations
Rutgers, The State University of New Jersey (US)
Venue
Annual Review of Nutrition
Published
2001-07
Volume
21
Issue
1
Pages
381-406
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
OpenAlex
W2158944838
Cited by
1,260
References
120
Citations by year
2026: 14 · 2025: 18 · 2024: 23 · 2023: 39 · 2022: 45 · 2021: 55 · 2020: 43 · 2019: 50 · 2018: 52 · 2017: 59 · 2016: 56 · 2015: 61 · 2014: 71 · 2013: 65 · 2012: 69
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA056673, CA56673)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
dietary polyphenols, anticarcinogenic activity, carcinogenesis inhibition, antioxidants, phenolic acids, tea catechins, isoflavones, soybean, quercetin, flavonoids, resveratrol, lignans, bioavailability, cancer prevention, cancer risk
MeSH terms
Absorption, Antioxidants, Biological Availability, Biotransformation, Catechin, Diet, Flavonoids, Humans, Isoflavones, Phenols, Polymers, Tea, Anticarcinogenic Agents

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