The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The thioredoxin system—From science to clinic
Abstract
The thioredoxin system—formed by thioredoxin reductase and its characteristic substrate thioredoxin—is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA‐synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine—ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized. © 2003 Wiley Periodicals, Inc. Med Res Rev, 24, No. 1, 40–89, 2004
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Cites
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene
Matsui, M., Oshima, M., Oshima, H., Takaku, K., Maruyama, T., Yodoi, J., & Taketo, M. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0208 · Cited by 546 · cited 1×
“Thioredoxin converts the Syrian hamster (29-231) recombinant prion protein to an insoluble form.”
BackgroundNonn, L., Williams, R. R., Erickson, R. P., & Powis, G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.916-922.2003 · Cited by 438
Cooper, C. E., Patel, R. P., Brookes, P. S., & Darley-Usmar, V. M. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02191-6 · Cited by 180
Cited by
Oxidative Stress and Antioxidant Defense
Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182439613 · Cited by 4,935
Mitochondrial metabolism of reactive oxygen species
Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336
Thioredoxin and Related Molecules–From Biology to Health and Disease
Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.25 · Cited by 724
Selenium: its role as antioxidant in human health
Tinggi, U. (2008) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-007-0019-4 · Cited by 607
The thioredoxin system in cancer
Arnér, E. S. J., & Holmgren, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.10.009 · Cited by 589
Metadata
- Authors
- Gromer, S., Urig, S., & Becker, K.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2003-10-21
- Volume
- 24
- Issue
- 1
- Pages
- 40-89
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2149585271
- Cited by
- 479
- References
- 5
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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