Cited by 181Redox biology and oxidative stressSulfur Compounds in BiologyNitric Oxide and Endothelin Effects

Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species

Cooper, Chris E., Patel, Rakesh P., Brookes, Paul S., Darley-Usmar, Victor M.·2002·Trends in Biochemical Sciences

Abstract

The control of signal transduction involves post-translational modification of proteins at key amino acids. Cysteine residues are important in the control of 'redox' cell-signaling pathways, as thiol chemistry offers the possibility of modification by structurally diverse species, including those derived from oxidized lipids, peroxides or nitric oxide. An important and provocative study of the modification of thiols in the transcription factor OxyR recently extended this hypothesis. The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule.

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Crossref · 10.1016/s0968-0004(02)02191-6

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Authors
Cooper, C. E., Patel, R. P., Brookes, P. S., & Darley-Usmar, V. M.
Affiliations
  • University of Essex (GB)
  • University of Alabama at Birmingham (US)
Corresponding author
Darley-Usmar, Victor M.
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2002-10
Volume
27
Issue
10
Pages
489-492
ISSN
0968-0004 (ISSN-L)
OpenAlex
W1999952146
Cited by
180
References
22
Citations by year
2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 11
FWCI
5.06
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Biochemical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
redox signaling, nanotransducers, thiol modification, cysteine residues, reactive oxygen species, reactive nitrogen species, nitrosative stress, OxyR, post-translational modification, protein oxidation, nitrosylation, oxidized lipids, peroxides, nitric oxide
MeSH terms
Animals, Cysteine, Escherichia coli, Oxidation-Reduction, Protein Processing, Post-Translational, Proteins, Sulfhydryl Compounds, Signal Transduction, Reactive Oxygen Species, Reactive Nitrogen Species

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