The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works

Role of reactive oxygen species (ROS) in apoptosis induction

Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F. (2000) · Apoptosis · doi:10.1023/a:1009616228304 · Cited by 2,774 · see citing works

The mitochondrial permeability transition

Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

The Atlas of Mouse Development

Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,749 · see citing works

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

Susín, S. A., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, É., Geuskens, M., & Kroemer, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1331 · Cited by 1,133 · see citing works

Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

Chae, H. Z., Robison, K. E., Poole, L. B., Church, G. M., Storz, G., & Rhee, S. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7017 · Cited by 749 · see citing works

Detection of catalase in rat heart mitochondria.

Radi, R., Turrens, J. F., Chang, L. Y., Bush, K. M., Crapo, J. D., & Freeman, B. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54740-2 · Cited by 573 · see citing works

The house mouse

Theiler, K. (1972) · Cited by 550 · see citing works

[57] Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria

Boveris, A. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05060-6 · Cited by 488 · see citing works

Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

Kokoszka, J. E., Coskun, P. E., Esposito, L., & Wallace, D. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051627098 · Cited by 488 · see citing works

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

Zambrowicz, B., Friedrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C., & Sands, A. (1998) · Nature · doi:10.1038/33423 · Cited by 436 · see citing works

Cloning and Expression of a Novel Mammalian Thioredoxin

Spyrou, G., Enmark, E., Miranda‐Vizuete, A., & Gustafsson, J.-Α. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2936 · Cited by 397 · see citing works

Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin

Chae, H. Z., Kim, H. J., Kang, S. W., & Rhee, S. G. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00037-6 · Cited by 390 · see citing works

Thioredoxin‐2 (TRX‐2) is an essential gene regulating mitochondria‐dependent apoptosis

Tanaka, T., Hosoi, F., Yamaguchi‐Iwai, Y., Nakamura, H., Masutani, H., Ueda, S., Nishiyama, A., Takeda, S., Wada, H., Spyrou, G., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1695 · Cited by 322 · cited 3× · see citing works

Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.

Chae, H. Z., Uhm, T.-B., & Rhee, S. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7022 · Cited by 309 · see citing works

UV activates growth factor receptors via reactive oxygen intermediates.

Huang, R. P., Wu, J. X., Fan, Y., & Adamson, E. D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.1.211 · Cited by 276 · see citing works

Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2

Gladyshev, V. N., Liu, A., Novoselov, S. V., Krysan, K., Sun, Q., Kryukov, V. M., Kryukov, G. V., & Lou, M. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100020200 · Cited by 234 · see citing works

Oxidative damage to mitochondria and aging

Remmen, H. V. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00093-6 · Cited by 233 · see citing works

A high-yield preparative method for isolation of rat liver mitochondria

Bustamante, E., Soper, J. W., & Pedersen, P. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90661-3 · Cited by 203 · see citing works

Human Mitochondrial Thioredoxin

Damdimopoulos, A. E., Miranda-Vizuete, A., Pelto-Huikko, M., Gustafsson, J.-Å., & Spyrou, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203036200 · Cited by 192 · see citing works

Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses

Miller, M. T., & Str�mland, K. (1999) · Teratology · doi:10.1002/(sici)1096-9926(199911)60:5 · Cited by 187 · see citing works

Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells*

Chen, Y., Cai, J.-Y., Murphy, T., & Jones, D. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202026200 · Cited by 166 · see citing works

The Mitochondrial Thioredoxin System

Miranda‐Vizuete, A., Damdimopoulos, A. E., & Spyrou, G. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.4-801 · Cited by 155 · see citing works

Glucose Metabolism By Rat Embryos in Vitro

Tanimura, T., & Shepard, T. H. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-135-34985 · Cited by 132 · see citing works

Reactive Oxygen Species Participate in the Control of Mouse Embryonic Cell Death

Vidal, E. S., Lomelı́, H., Castro‐Obregón, S., Cuervo, R., Escalante‐Alcalde, D., & Covarrubias, L. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3828 · Cited by 119 · see citing works

Mice with a Partial Deficiency of Manganese Superoxide Dismutase Show Increased Vulnerability to the Mitochondrial Toxins Malonate, 3-Nitropropionic Acid, and MPTP

Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Albers, D. W., Klivènyi, P., Carlson, E. J., Epstein, C. J., & Beal, M. F. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7525 · Cited by 114 · see citing works

Decreased Pulmonary Radiation Resistance of Manganese Superoxide Dismutase (MnSOD)-Deficient Mice is Corrected by Human Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Intratracheal Gene Therapy

Epperly, M. W., Epstein, C. J., Travis, E. L., & Greenberger, J. S. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)154[0365:dprrom]2.0.co;2 · Cited by 93 · see citing works

Selenium regulation of thioredoxin reductase activity and mRNA levels in rat liver

Hadley, K. B., & Sunde, R. A. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00189-9 · Cited by 90 · see citing works

Ultrastructural study of mitochondria and their cristae in embryonic rats and primate (N. nemistrina)

Shepard, T. H., Muffley, L. A., & Smith, L. T. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199811)252:3 · Cited by 78 · see citing works

Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping

Knopp, E. A., Arndt, T. L., Eng, K., Caldwell, M., LeBoeuf, R. C., Deeb, S. S., & O’Brien, K. D. (1999) · Mammalian Genome · doi:10.1007/s003359901053 · Cited by 61 · see citing works

Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity

Asikainen, T. M., Huang, T., Taskinen, E., Levonen, A., Carlson, E. J., Lapatto, R., Epstein, C. J., & Raivio, K. O. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00776-6 · Cited by 48 · see citing works

cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene

Miranda‐Vizuete, A., Damdimopoulos, A. E., & Spyrou, G. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00129-3 · Cited by 44 · see citing works

Crosstalk of reactive oxygen species and NF-κB signaling

Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505 · see citing works

Mitochondria, oxidative stress and cell death

Ott, M., Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0756-2 · Cited by 1,976 · see citing works

From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

Papp, L. V., Lu, J., Holmgren, A., & Khanna, K. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1528 · Cited by 1,332 · see citing works

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works

Mitochondrial Oxidative Stress: Implications for Cell Death

Orrenius, S., Gogvadze, V. G., & Zhivotovsky, B. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105122 · Cited by 1,266 · see citing works

Trends in oxidative aging theories

Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works

Selenium, Selenoproteins, and Immunity

Avery, J., & Hoffmann, P. R. (2018) · Nutrients · doi:10.3390/nu10091203 · Cited by 913 · see citing works

Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals

Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776 · see citing works

Mitochondrial Energetics and Therapeutics

Wallace, D. C., Fan, W., & Procaccio, V. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092314 · Cited by 727 · see citing works

Thioredoxin and Related Molecules–From Biology to Health and Disease

Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.25 · Cited by 724 · see citing works

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Hanschmann, E.-M., Godoy, J. R., Berndt, C., Hudemann, C., & Lillig, C. H. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4599 · Cited by 677 · see citing works

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

Arnér, E. S. J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.014 · Cited by 675 · see citing works

Redox compartmentalization in eukaryotic cells.

Go, Y., & Jones, D. P. (2008) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagen.2008.01.011 · Cited by 635 · see citing works

Is the oxidative stress theory of aging dead?

Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Bindoli, A., Rigobello, M. P., Scutari, G., Gabbiani, C., Casini, A., & Luigi Messori, A. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.02.026 · Cited by 594 · see citing works

The thioredoxin system in cancer

Arnér, E. S. J., & Holmgren, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.10.009 · Cited by 589 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Anticancer Activity of Metal Complexes: Involvement of Redox Processes

Jungwirth, U., Kowol, C. R., Keppler, B. K., Hartinger, C. G., Berger, W., & Heffeter, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3663 · Cited by 559 · see citing works

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009) · Biochemical Journal · doi:10.1042/bj20091541 · Cited by 530 · see citing works

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

Meyer, Y., Buchanan, B. B., Vignols, F., & Reichheld, J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134201 · Cited by 482 · see citing works

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9414-9423.2004 · Cited by 485 · see citing works

Genetics and development of neural tube defects

Copp, A. J., & Greene, N. D. E. (2009) · The Journal of Pathology · doi:10.1002/path.2643 · Cited by 480 · see citing works

The thioredoxin system—From science to clinic

Gromer, S., Urig, S., & Becker, K. (2003) · Medicinal Research Reviews · doi:10.1002/med.10051 · Cited by 482 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

Lei, X. G., Zhu, J., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 437 · see citing works

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

Jones, N. C., Lynn, M. L., Gaudenz, K., Sakai, D., Aoto, K., Rey, J., Glynn, E. F., Ellington, L. R., Du, C., Dixon, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1725 · Cited by 426 · see citing works

Reactive Oxygen Species in Mitochondria-Mediated Cell Death

Orrenius, S. (2007) · Drug metabolism reviews (Softcover ed.) · doi:10.1080/03602530701468516 · Cited by 455 · see citing works

Function of reactive oxygen species during animal development: Passive or active?

Covarrubias, L., Hernández-García, D., Schnabel, D., Vidal, E. S., & Castro‐Obregón, S. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.041 · Cited by 402 · see citing works

Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development

Jakupoglu, C., Przemeck, G. K. H., Schneider, M., Moreno, S. G., Mayr, N., Hatzopoulos, A. K., de Angelis, M. H., Wurst, W., Bornkamm, G. W., Brielmeier, M., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1980-1988.2005 · Cited by 357 · see citing works

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00734-4 · Cited by 357 · see citing works

Selenocysteine in proteins—properties and biotechnological use

Johansson, L., Gafvelin, G., & Arnér, E. S. J. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.05.010 · Cited by 353 · see citing works

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

Berndt, C., Lillig, C. H., & Holmgren, A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01162.2006 · Cited by 350 · see citing works

Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

Karihtala, P., & Soini, Y. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_514.x · Cited by 342 · see citing works

Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 337 · see citing works

Mitochondria as therapeutic targets for cancer chemotherapy

Galluzzi, L., Larochette, N., Zamzami, N., & Kroemer, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209598 · Cited by 342 · see citing works

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

Banjac, A., Perisic, T., Sato, H., Seiler, A., Bannai, S., Weiss, N., Kölle, P., Tschoep, K., Issels, R. D., Daniel, P. T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210796 · Cited by 324 · see citing works

Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects

Harris, M. J., & Juriloff, D. M. (2006) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20333 · Cited by 311 · see citing works

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

Mahmood, D. F. D., Abderrazak, A., Hadri, K. E., Simmet, T., & Rouis, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4757 · Cited by 305 · see citing works

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

Leung, L., Kwong, M., Hou, S., Lee, C., & Chan, J. Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308439200 · Cited by 299 · see citing works

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T. E., Vatner, S. F., & Sadoshima, J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17700 · Cited by 274 · see citing works

System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

Mandal, P. K., Seiler, A., Perisic, T., Kölle, P., Banjac Canak, A., Förster, H., Weiss, N., Kremmer, E., Lieberman, M. W., Bannai, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121327 · Cited by 269 · see citing works

Thioredoxin-2 Inhibits Mitochondria-Located ASK1-Mediated Apoptosis in a JNK-Independent Manner

Zhang, R., Al-Lamki, R., Bai, L., Streb, J. W., Miano, J., Bradley, J., & Min, W. (2004) · Circulation Research · doi:10.1161/01.res.0000130525.37646.a7 · Cited by 273 · see citing works

The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease

Papaconstantinou, J. (2019) · Cells · doi:10.3390/cells8111383 · Cited by 259 · see citing works

Thioredoxin and Its Role in Toxicology

Watson, W. H. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfh050 · Cited by 246 · see citing works

Human selenoproteins at a glance

Gromer, S., Eubel, J., Lee, B. L., & Jacob, J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5143-y · Cited by 245 · see citing works

Redox Regulation of Cellular Stress Response in Aging and Neurodegenerative Disorders: Role of Vitagenes

Calabrese, V., Guagliano, E., Sapienza, M. A., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Mancuso, C., Butterfield, D. A., & Stella, A. G. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9203-y · Cited by 241 · see citing works

Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.

Nonn, L., Berggren, M. M., & Powis, G. (2003) · PubMed · Cited by 216 · see citing works

PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B., et al. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2940 · Cited by 215 · see citing works

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works

Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system

Drechsel, D. A., & Patel, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.101196 · Cited by 199 · see citing works

Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2 Emission from Isolated Heart Mitochondria

Stanley, B. A., Sivakumaran, V., Shi, S., McDonald, I., Lloyd, D., Watson, W. H., Aon, M. A., & Paolocci, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.284612 · Cited by 197 · see citing works

Glutathione‐dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

Zhang, H., Limphong, P., Pieper, J., Liu, Q., Rodesch, C., Christians, E., & Benjamin, I. (2012) · The FASEB Journal · doi:10.1096/fj.11-199869 · Cited by 201 · see citing works

Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations

Brennan, L., & Kantorow, M. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.05.018 · Cited by 193 · see citing works

Oxidative stress and cell death

Rumora, L., Petrik, J., & Žanić‐Grubišić, T. (2003) · Cited by 192 · see citing works

Principles in Redox Signaling: From Chemistry to Functional Significance

Bindoli, A., & Rigobello, M. P. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4655 · Cited by 189 · see citing works

Thioredoxin and Its Related Molecules: Update 2005

Nakamura, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.823 · Cited by 185 · see citing works

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 189 · see citing works

Reactive oxygen species: A radical role in development?

Hernández-García, D., Wood, C., Castro-Obregón, S., & Covarrubias, L. (2010) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2010.03.020 · Cited by 207 · see citing works

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Liu, X., Zhang, Y., Zhuang, L., Olszewski, K. L., & Gan, B. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.11.010 · Cited by 184 · see citing works

Thioredoxin-2 Inhibits Mitochondrial ROS Generation and ASK1 Activity to Maintain Cardiac Function

Huang, Q.-H., Zhou, H., Zhang, H.-F., Huang, Y., Hinojosa-Kirschenbaum, F., Fan, P., Yao, L., Belardinelli, L., Tellides, G., Giordano, F. J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.012725 · Cited by 149 · see citing works

Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration

Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., Cheeseman, M. T., Davies, B., & Davies, K. E. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002338 · Cited by 171 · see citing works

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168 · see citing works

The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

Cox, A. G., Brown, K., Arnér, E. S. J., & Hampton, M. B. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.08.021 · Cited by 164 · see citing works

Mitochondrial Thioredoxin-Responding Off–On Fluorescent Probe

Lee, M. H., Han, J. H., Lee, J.-H., Choi, H. G., Kang, C., & Kim, J. S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308446y · Cited by 161 · see citing works

The system biology of thiol redox system in Escherichia coli and yeast: Differential functions in oxidative stress, iron metabolism and DNA synthesis

Tolédano, M. B., Kumar, C., Moan, N. L., Spector, D., & Tacnet, F. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.002 · Cited by 159 · see citing works

Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance

He, F., Huang, Y., Song, Z. Q., Zhou, H. J., Zhang, H., Perry, R. J., Shulman, G. I., & Wang, M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201416 · Cited by 158 · see citing works

Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress

Li, L., Shoji, W., Takano, H., Nishimura, N., Aoki, Y., Takahashi, R., Goto, S., Kaifu, T., Takai, T., & Obinata, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.022 · Cited by 153 · see citing works

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

Kalinina, E. V., Chernov, N., & Saprin, A. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908130099 · Cited by 159 · see citing works

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

Lillig, C. H., Lönn, M. E., Enoksson, M., Fernandes, A. P., & Holmgren, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401896101 · Cited by 147 · see citing works

Redox balance and cardioprotection

Tullio, F., Angotti, C., Perrelli, M.-G., Penna, C. R. R., & Pagliaro, P. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0392-7 · Cited by 148 · see citing works

Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation

Mandal, P. K., Schneider, M., Kölle, P., Kuhlencordt, P. J., Förster, H., Beck, H., Bornkamm, G. W., & Conrad, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1509 · Cited by 145 · see citing works

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Sahoo, S., Meijles, D. N., & Pagano, P. J. (2016) · Clinical Science · doi:10.1042/cs20150087 · Cited by 146 · see citing works

Redox Regulation of Cell Survival by the Thioredoxin Superfamily: An Implication of Redox Gene Therapy in the Heart

Ahsan, M., Lekli, I., Ray, D., Yodoi, J., & Das, D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2683 · Cited by 134 · see citing works

Selenium Cytotoxicity in Cancer

Wallenberg, M., Misra, S., & Björnstedt, M. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12207 · Cited by 135 · see citing works

Selenoproteins and the aging brain

Zhang, S., Rocourt, C. R. B., & Cheng, W. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.006 · Cited by 135 · see citing works

High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

Eriksson, S. E., Prast‐Nielsen, S., Flaberg, E., Székely, L., & Arnér, E. S. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.016 · Cited by 128 · see citing works

Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

McCann, J. C., & Ames, B. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-180885 · Cited by 125 · see citing works

Redox atlas of the mouse

Godoy, J. R., Funke, M., Ackermann, W., Haunhorst, P., Oesteritz, S., Capani, F., Elsässer, H., & Lillig, C. H. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.05.006 · Cited by 124 · see citing works

Mitochondrial Thiols in the Regulation of Cell Death Pathways

Yin, F., Sancheti, H., & Cadenas, E. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4639 · Cited by 112 · see citing works

Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions

Maulik, N., & Das, D. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.12.008 · Cited by 124 · see citing works

Negative regulators of cardiac hypertrophy

Hardt, S. E. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.015 · Cited by 122 · see citing works

Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

Rackham, O., Shearwood, A.-M. J., Thyer, R. T., McNamara, E. L., Davies, S. M. K., Callus, B. A., Miranda‐Vizuete, A., Berners‐Price, S. J., Cheng, Q., Arnér, E. S. J., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.015 · Cited by 121 · see citing works

Redox Control in Mammalian Embryo Development

Ufer, C., Wang, C. C., Borchert, A., Heydeck, D., & Kühn, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3044 · Cited by 120 · see citing works

Thioredoxin h 5 Is Required for Victorin Sensitivity Mediated by a CC-NBS-LRR Gene in Arabidopsis

Sweat, T. A., & Wolpert, T. (2007) · The Plant Cell · doi:10.1105/tpc.106.047563 · Cited by 120 · see citing works

Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells

Čėnas, N., Prast‐Nielsen, S., Nivinskas, H., Šarlauskas, J., & Arnér, E. S. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511972200 · Cited by 119 · see citing works

The Emerging Role of the Thioredoxin System in Angiogenesis

Dunn, L., Buckle, A., Cooke, J. P., & Ng, M. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209643 · Cited by 119 · see citing works

Free Radicals and Reactive Oxygen Species

Kehrer, J., Robertson, J., & Smith, C. V. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00114-7 · Cited by 95 · see citing works

Salmonella Type III Secretion Effector SlrP Is an E3 Ubiquitin Ligase for Mammalian Thioredoxin

Bernal-Bayard, J., & Ramos‐Morales, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010363 · Cited by 117 · see citing works

Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome

Bondareva, A. A., Capecchi, M. R., Iverson, S. V., Li, Y., Lopez, N. I., Lucas, O., Merrill, G. F., Prigge, J. R., Siders, A. M., Wakamiya, M., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.026 · Cited by 117 · see citing works

The Role of Thioredoxin Reductases in Brain Development

Soerensen, J., Jakupoglu, C., Beck, H., Förster, H., Schmidt, J., Schmahl, W., Schweizer, U., Conrad, M., & Brielmeier, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001813 · Cited by 114 · see citing works

The thioredoxin system in retroviral infection and apoptosis

Masutani, H., Ueda, S., & Yodoi, J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401625 · Cited by 114 · see citing works

Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer’s Rat Model

Wu, C., Yang, L., Tucker, D., Dong, Y., Zhu, L., Duan, R., Liu, T. C., & Zhang, Q. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001519 · Cited by 113 · see citing works

Mitochondrial Thioredoxin System

Patenaude, A., Murthy, M. R. V., & Mirault, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402496200 · Cited by 140 · see citing works

Nucleoredoxin, a Novel Thioredoxin Family Member Involved in Cell Growth and Differentiation

Funato, Y., & Miki, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1550 · Cited by 114 · see citing works

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.

Pérez, V. I., Lew, C. M., Cortez, L. A., Webb, C. R., Rodriguez, M. R., Liu, Y.-H., Qi, W., Li, Y., Chaudhuri, A., Remmen, H. V., et al. (2008) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2007.11.018 · Cited by 118 · see citing works

Stress Induction and Mitochondrial Localization of Oxr1 Proteins in Yeast and Humans

Elliott, N., & Volkert, M. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3180-3187.2004 · Cited by 111 · see citing works

Regulation of Cell Survival and Death by Pyridine Nucleotides

Oka, S., Hsu, C., & Sadoshima, J. (2012) · Circulation Research · doi:10.1161/circresaha.111.247932 · Cited by 109 · see citing works

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

Dey, S., Sidor, A., & O'Rourke, B. P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.726968 · Cited by 111 · see citing works

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

Chocrón, E. S., Munkácsy, E., & Pickering, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.035 · Cited by 106 · see citing works

Reactive Oxygen Species and the Aging Eye

Babizhayev, M. A., & Yegorov, Y. E. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181ea31ff · Cited by 103 · see citing works

The mitochondrial thioredoxin is required for liver development in zebrafish.

Zhang, J., Cui, X., Wang, L., Liu, F., Jiang, T., Li, C., Li, D. W. C., Huang, M., Liao, S., Wang, J., et al. (2014) · Current molecular medicine · doi:10.2174/1566524014666140724103927 · Cited by 9 · see citing works

THE ROLE OF THE MITOCHONDRIAL THIOREDOXIN-2 SYSTEM IN CELL FUNCTION

Nonn, L. (2003) · UA Campus Repository (The University of Arizona) · Cited by 1 · see citing works

Mitochondrial Thioredoxin System

Patenaude, A., Murthy, M. R. V., & Mirault, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402496200 · Cited by 140 · see citing works

Thioredoxin‐2 (TRX‐2) is an essential gene regulating mitochondria‐dependent apoptosis

Tanaka, T., Hosoi, F., Yamaguchi‐Iwai, Y., Nakamura, H., Masutani, H., Ueda, S., Nishiyama, A., Takeda, S., Wada, H., Spyrou, G., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1695 · Cited by 322 · see citing works

Mitochondrial and cytosolic thioredoxin reductase knockout mice

Conrad, M., Bornkamm, G. W., & Brielmeier, M. (2007) · Springer eBooks · doi:10.1007/0-387-33827-6_18 · Cited by 9 · see citing works