Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents

Cited by (795)

Items 401–500 of 795

1. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor
   Xia Wen, Gabriell Thorne, Longqin Hu, Melanie S. Joy, Lauren M. Aleksunes · 2015 · Journal of Biochemical and Molecular Toxicology
2. Dexmedetomidine Pretreatment Attenuates Kidney Injury and Oxidative Stress during Orthotopic Autologous Liver Transplantation in Rats
   Xiaofang Yu, Xinjin Chi, Shan Wu, Yi Jin, Hui Yao, Yiheng Wang, Zhengyuan Xia, Jun Cai · 2015 · Oxidative Medicine and Cellular Longevity
3. Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms
   Aurélie de Rus Jacquet, Mitali Arun Tambe, Sin Ying Ma, George P. McCabe, Jay Hansford C. Vest, Jean‐Christophe Rochet · 2017 · Journal of Ethnopharmacology
4. Effects of epigallocatechin-3-gallate on oxidative stress, inflammation, and bone loss in a rat periodontitis model
   Fan Qin, Xiao-Hong Zhou, Tengfei Wang, Fengjiao Zeng, Xia Liu, Yu Xuan Gu, Bin Chen, Jie Yang, Zi-Yi Pang, Jianguo Liu et al. · 2023 · Journal of Dental Sciences
5. Neuroprotective effects of flavonoids: endoplasmic reticulum as the target
   Bita Amiri, Maryam Yazdani Tabrizi, Mahdyieh Naziri, Farzaneh Moradi, Mohammadreza Arzaghi, Iman Archin, Fatemeh Behaein, Anahid Bagheri Pour, Parna Ghannadikhosh, Saba Imanparvar et al. · 2024 · Frontiers in Neuroscience
6. Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
   Nicole Blaquière, Elisia Villemure, Steven T. Staben · 2020 · Journal of Medicinal Chemistry
7. Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display
   Gurkan Guntas, Steven M. Lewis, Kathleen M. Mulvaney, Erica W. Cloer, Ashutosh Tripathy, Thomas R. Lane, Michael B. Major, Brian A. Kuhlman · 2015 · Protein Engineering Design and Selection
8. Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells
   Rebeca Alvariño, Eva Alonso, Marie‐Aude Tribalat, Sandra Gegunde, OP Thomas, Luis Miguel Botana · 2017 · Neurotoxicity Research
9. Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets
   Sabrina Taliani, Federico Da Settimo, Claudia Martini, Sonia Laneri, Ettore Novellino, Giovanni Greco · 2020 · Molecules
10. Angelica Sinensis polysaccharide antagonizes 5-Fluorouracil-induced spleen injury and dysfunction by suppressing oxidative stress and apoptosis
    Kunhang Du, Lu Wang, Ziling Wang, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Ningke Fan, Yaping Wang · 2023 · Biomedicine & Pharmacotherapy
11. Curcumin and a hemi-analogue with improved blood–brain barrier permeability protect against amyloid-beta toxicity in Caenorhabditis elegans via SKN-1/Nrf activation
    Elaine Hui-Chien Lee, Sherlyn Sheau-Chin Lim, Kah-Hay Yuen, Chong Yew Lee · 2018 · Journal of Pharmacy and Pharmacology
12. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction
    Sumi Lee, Dhulfiqar Ali Abed, Lesa J. Beamer, Longqin Hu · 2020 · SLAS DISCOVERY
13. Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
    Debasis Mondal, Devin Narwani, Shahnawaz Notta, Dawood Ghaffar, Nikhil Maneesh Mardhekar, Syed S. A. Quadri · 2020 · Cancer Drug Resistance
14. Prognostic value of a novel glycolysis-related gene expression signature for gastrointestinal cancer in the Asian population
    Rong Mu Xia, Hua Tang, Jiemiao Shen, Shuyu Xu, Yinyin Liang, Yuxin Zhang, Xing Gong, Yue Min, Di Zhang, Chenzhe Tao et al. · 2021 · Cancer Cell International
15. Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress
    Lin Chen, Qin Ru, Qi Xiong, Jun Yang, Guodong Xu, Yuxiang Wu · 2022 · Oxidative Medicine and Cellular Longevity
16. Polyethylene glycol capped gold nanoparticles ameliorate renal ischemia–reperfusion injury in diabetic mice through AMPK-Nrf2 signaling pathway
    Hanan Mohammed Saleh, Mohamed Salama, Rehab Hussein · 2022 · Environmental Science and Pollution Research
17. Flexion of Nrf2 by tea phytochemicals: A review on the chemopreventive and chemotherapeutic implications
    Suchisnigdha Datta, Sukanya Ghosh, Anupam Bishayee, Dona Sinha · 2022 · Pharmacological Research
18. Involvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin
    Leiyan He, Yao-xue Guo, Ye Deng, Li Chun, Cheng-zi Zuo, Wenxing Peng · 2017 · Xenobiotica
19. Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activities
    Yakov F. Zverev · 2017 · Reviews on Clinical Pharmacology and Drug Therapy
20. Eukaryotic cell survival mechanisms: Disease relevance and therapeutic intervention
    Krishna Sundar Twayana, Palaniyandi Ravanan · 2018 · Life Sciences
21. Protective effect of Schisandra chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway
    Lianlin Su, Ping Li, Tulin Lu, Chunqin Mao, De Ji, Min Hao, Ziyan Huang · 2019 · Revista Brasileira de Farmacognosia
22. Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
    Pablo Duarte, Patrycja Michalska, Enrique Crisman, Antonio Cuadrado, Rafael M. Leon · 2022 · Antioxidants
23. CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome
    Sara Emanuela Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittalà, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini et al. · 2022 · Free Radical Biology and Medicine
24. Biological mechanisms and clinical efficacy of sulforaphane for mental disorders
    Wensi Zheng, Xiaolong Li, Tianhong Zhang, Jijun Wang · 2022 · General Psychiatry
25. Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis
    G. McCreath, Malo M.F. Scullion, Damon A. Lowes, Nigel R. Webster, Helen F. Galley · 2015 · British Journal of Anaesthesia
26. Epalrestat Upregulates Heme Oxygenase-1, Superoxide Dismutase, and Catalase in Cells of the Nervous System
    Kaori Yama, Keisuke Sato, Yu Murao, Ryosuke Tatsunami, Yoshiko Tampo · 2016 · Biological and Pharmaceutical Bulletin
27. A rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders
    Kathrin Schmeißer, Yasmin Fardghassemi, J. Alex Parker · 2017 · Experimental Neurology
28. Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology
    Ivana Matić, Daniela Strobbe, Michele Frison, Michelangelo Campanella · 2015 · Pharmacological Research
29. Protective effect of low molecular-weight seleno-aminopolysaccharides against H2O2-induecd oxidative stress in intestinal epithelial cells
    Zhengshun Wen, Li Ma, Xingwei Xiang, Zhen Tang, Rongfa Guan, Youle Qu · 2018 · International Journal of Biological Macromolecules
30. Advances in Immunosuppressive Agents Based on Signal Pathway
    Zhiqing Xu, Ming Chu · 2022 · Frontiers in Pharmacology
31. RedOx Status, Proteasome and APEH: Insights into Anticancer Mechanisms of t10,c12-Conjugated Linoleic Acid Isomer on A375 Melanoma Cells
    Paolo Bergamo, Ennio Cocca, Rosanna Palumbo, Marta Gogliettino, Mosé Rossi, Gianna Palmieri · 2013 · PLoS ONE
32. Cafestol Inhibits Cyclic‐Strain‐Induced Interleukin‐8, Intercellular Adhesion Molecule‐1, and Monocyte Chemoattractant Protein‐1 Production in Vascular Endothelial Cells
    Wen‐Rui Hao, Li‐Chin Sung, Chun‐Chao Chen, Po‐Yuan Chen, Tzu‐Hurng Cheng, Hung‐Hsing Chao, Ju‐Chi Liu, Jin-Jer Chen · 2018 · Oxidative Medicine and Cellular Longevity
33. Reactive oxygen species in health and disease
    Yaoxing Ren, Jitian Li, Xiaofeng Dai · 2026 · Molecular Biomedicine
34. The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity
    Michele Frison, Danilo Faccenda, Rosella Abeti, Manuel Rigon, Daniela Strobbe, Britannie S. England-Rendon, Diana Cash, Katy Barnes, Mona Sadeghian, Marija Sajic et al. · 2021 · Molecular Psychiatry
35. Evidence for Multilevel Chemopreventive Activities of Natural Phenols from Functional Genomic Studies of Curcumin, Resveratrol, Genistein, Quercetin, and Luteolin
    Łukasz Huminiecki · 2022 · International Journal of Molecular Sciences
36. Sulforaphane, an Nrf-2 Agonist, Modulates Oxidative Stress and Inflammation in a Rat Model of Cuprizone-Induced Cardiotoxicity and Hepatotoxicity
    Ghadha Ibrahim Fouad · 2023 · Cardiovascular Toxicology
37. Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin’s neuroprotective action against diabetes-induced cognitive impairment
    Yanfang Zheng, Chenxiang Wang, Wenjing Liu, Jiaying Chen, Yibin Sun, Dennis Chang, Huan Wang, Wen Xu, Jin‐Jian Lu, Xian Zhou et al. · 2024 · Biomedicine & Pharmacotherapy
38. Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue
    Yoon Jin Lee, Sun Bum Kwon, Chul Han Kim, Hyun Deuk Cho, Hae Seon Nam, Sang-Han Lee, Mi Woo Lee, Doo Hyun Nam, Chang Yong Choi, Moon Kyun Cho · 2015 · Annals of Dermatology
39. Nuclear factor erythroid 2-related factor 2-antioxidant activation through the action of ataxia telangiectasia-mutated serine/threonine kinase is essential to counteract oxidative stress in bovine mammary epithelial cells
    Y.F. Ma, Z.H. Wu, Min Gao, Juan J. Loor · 2018 · Journal of Dairy Science
40. Low-dose dexamethasone in combination with luteolin improves myocardial infarction recovery by activating the antioxidative response
    Haitao Wang, Xiaoqin Yao, Keli Huang, Jing Zhang, Jingrong Xiao, Jìng Guo, Dachuang Wei, Bo Xiang · 2022 · Biomedicine & Pharmacotherapy
41. Emerging Therapeutic Targets in Oncologic Photodynamic Therapy
    Gina Manda, Mihail Eugen Hinescu, Ionela Victoria Neagoe, L.F. Vieira Ferreira, Rica Boscencu, Paul R. Vasos, Selma Huveyda Basaga, Antonio Cuadrado · 2019 · Current Pharmaceutical Design
42. Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment
    Jannik Paulus, Norbert Sewald · 2024 · Journal of Peptide Science
43. Targeting metabolic diseases with celastrol: A comprehensive review of anti-inflammatory mechanisms and therapeutic potential
    Xiaojuan Wang, Mohamad Hafizi Abu Bakar, Song Liqun, Mohd Asyraf Kassim, Khairul Anuar Shariff, Thiruventhan Karunakaran · 2025 · Journal of Ethnopharmacology
44. Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling
    Feng Li, Jing Liang, Dongfang Tang · 2018 · Biomedicine & Pharmacotherapy
45. Downregulation of Keap1 contributes to poor prognosis and Axitinib resistance of renal cell carcinoma via upregulation of Nrf2 expression
    Haipeng Huang, Yunhong Wu, Weijin Fu, Xiaoming Wang, Liquan Zhou, Xiaolong Xu, Fu Huang, Yi Wu · 2019 · International Journal of Molecular Medicine
46. The electrophilic character of quinones is essential for the suppression of Bach1
    Chuanyang Su, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song · 2017 · Toxicology
47. An overview of the possible therapeutic role of SUMOylation in the treatment of Alzheimer’s disease
    Serena Marcelli, Elena Ficulle, Laura Piccolo, Massimo Corbo, Marco Feligioni · 2017 · Pharmacological Research
48. Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1
    June Lee, Karabasappa Mailar, Ok-Kyung Yoo, Won Jun Choi, Young‐Sam Keum · 2018 · European Journal of Medicinal Chemistry
49. Dissecting the prevention of estrogen-dependent breast carcinogenesis through Nrf2-dependent and independent mechanisms
    Aldo Giudice, Antônio Barbieri, Sabrina Bimonte, Marco Cascella, Arturo Cuomo, Anna Crispo, Giovanni Francesco D'Arena, Massimiliano Galdiero, Maria Elena Della Pepa, Gerardo Botti et al. · 2019 · OncoTargets and Therapy
50. Use of nanoparticles of metals and non-metals in poultry farming
    Оksana Tsekhmistrenko, V. Bityutskyy, Svitlana Tsekhmistrenko, O. Melnychenko, N. O. Tymoshok, M. Spivak · 2019 · Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva
51. Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes
    Zi‐Long Song, Feifei Bai, Baoxin Zhang, Jianguo Fang · 2020 · Journal of Agricultural and Food Chemistry
52. Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer
    Pinghan Wang, Fangyi Long, Hong Lin, Song Wang, Ting Wang · 2022 · Oxidative Medicine and Cellular Longevity
53. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome
    Zhen Dai, Lu-yan An, Xiao-yi Chen, Fan Yang, Ni Zhao, Cuicui Li, Ren Ren, Bingyan Li, Weiyan Tao, Pei Li et al. · 2022 · Journal of Medicinal Chemistry
54. Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms
    Xuefeng Liu, Qi Wang, Jia-Fang Zheng, Zuo-Hu Chai, Fang Dai, Xiaojie Jin, Bo Zhou · 2022 · Free Radical Biology and Medicine
55. An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver
    Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldomero Oliva, Marı́a Isabel Rodrı́guez-Franco, Ana Isabel Rojo, Antonio Cuadrado · 2022 · Redox Biology
56. Construction of a novel quinoxaline as a new class of Nrf2 activator
    Murugesh Kandasamy, Kit‐Kay Mak, Thangaraj Devadoss, Punniyakoti Thanikachalam Veeraveedu, Raghavendra Sakirolla, Hira Choudhury, Mallikarjuna Rao Pichika · 2019 · BMC Chemistry
57. Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries
    Li‐Ye Liang, Mengmeng Wang, Liu Ming, Wei Zhao, Xin Wang, Lin Shi, Mei-Jia Zhu, Yuan‐Ling Zhao, Lian Liu, Preeti Maurya et al. · 2019 · Toxicology in Vitro
58. Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats
    Chia-Fa Lin, Tsung-Hung Chueh, Cheng-Hsun Chung, Shue-Dong Chung, Tzu-Ching Chang, Chiang‐Ting Chien · 2019 · Journal of the Formosan Medical Association
59. Mechanisms of pollutant-induced toxicity in skin and detoxification: Anti-pollution strategies and perspectives for cosmetic products
    Fanny Richard, T. Creusot, Sophie Catoire, Christophe Egles, Hervé Ficheux · 2019 · Annales Pharmaceutiques Françaises
60. Stevia rebaudianaextract attenuate metabolic disorders in diabetic ratsviamodulation of glucose transport and antioxidant signaling pathways and aquaporin‐2 expression in two extrahepatic tissues
    Elahe Bayat, Zahra Rahpeima, Sanaz Dastghaib, Fatemeh Gholizadeh, Mehran Erfani, Gholamreza Asadikaram, Pooneh Mokarram · 2020 · Journal of Food Biochemistry
61. Design, synthesis, and evaluation of mono‐carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis
    Ya Ning Zhao, Zhiwei Zheng, Menghan Zhang, Yi Wang, Rongdang Hu, Weijia Lin, Chenyang Huang, Chuchu Xu, Jianzhang Wu, Hui Deng · 2021 · Journal of Periodontal Research
62. Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation
    Dhulfiqar Ali Abed, Sumi Lee, Xia Wen, Ahmed R. Ali, Vaibhav S. Mangipudy, Lauren M. Aleksunes, Longqin Hu · 2021 · Bioorganic & Medicinal Chemistry
63. Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose
    Huankai Yao, Wenting Zhang, Feng Yang, Fengwei Ai, Dan Du, Yan Li · 2021 · Journal of Enzyme Inhibition and Medicinal Chemistry
64. Calcitriol Ameliorates Brain Injury in the Rat Model of Cerebral Ischemia-Reperfusion Through Nrf2/HO-1 Signalling Axis: An in Silico and in Vivo Study
    Zeinab Vahidinia, Negar Khassafi, Abolfazl Azami Tameh, Mohammad Karimian, Zahra Zare-Dehghanani, Fatemeh Moradi, Mohammad Taghi Joghataei · 2022 · Journal of Stroke and Cerebrovascular Diseases
65. Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and the possible mechanism
    Zheng Shi, Zhe‐Peng Deng, Xiaoyu Peng, Yongqiang Tian · 2022 · Journal of Ethnopharmacology
66. Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake
    Jiaojiao Zhang, Shaozhen Wu, Qingqing Wang, Qinjie Yuan, Yane Li, Patricia Reboredo‐Rodríguez, Alfonso Varela‐López, Zhiping He, Fenghua Wu, Hao Hu et al. · 2022 · International Journal of Molecular Sciences
67. Designing a whole cell bioreporter to show antioxidant activities of agents that work by promotion of the KEAP1–NRF2 signaling pathway
    Negar Mozaheb, Ehsan Arefian, Mohammad Ali Amoozegar · 2019 · Scientific Reports
68. Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction
    Tao Shen, Haizhen Li, Ailing Li, Yanru Li, Xiao‐Ning Wang, Dong‐Mei Ren · 2018 · Vascular Pharmacology
69. Treatment of dilated cardiomyopathy in a mouse model of Friedreich’s ataxia using N-acetylcysteine and identification of alterations in microRNA expression that could be involved in its pathogenesis
    Shannon Chiang, Michael L.H. Huang, Des Raymond Richardson · 2020 · Pharmacological Research
70. Protective Effects of Ginsenosides (20R)‐Rg3 on H2O2‐Induced Myocardial Cell Injury by Activating Keap‐1/Nrf2/HO‐1 Signaling Pathway
    Yan Dong Zhao, Yu Wang, Min Zhang, Yugang Gao, Zhaowei Yan · 2021 · Chemistry & Biodiversity
71. Bromophenol Bis (2,3,6-Tribromo-4,5-dihydroxybenzyl) Ether Protects HaCaT Skin Cells from Oxidative Damage via Nrf2-Mediated Pathways
    Hui Dong, Mingfei Liu, Li Wang, Yankai Liu, Xuxiu Lu, Dimitrios Stagos, Xiukun Lin, Ming Liu · 2021 · Antioxidants
72. Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model
    Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama et al. · 2021 · Kidney360
73. Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury
    Bolin Bao, Hanghang Liu, Yaobao Han, Liyao Xu, Wei Xing, Zhen Li · 2023 · ACS Applied Materials & Interfaces
74. Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice
    Liying Tang, Houjian Zhang, Yi Liao, Shengmei Zhou, Yaqiong Yang, Mouxin Zhang, Yuli Guo, Tingyu Xie, Shikun Chen, Weijie Ouyang et al. · 2024 · American Journal Of Pathology
75. Synthesis of coumarin derivatives and their cytoprotective effects on t-BHP-induced oxidative damage in HepG2 cells
    Tomomi Ando, Mina Nagumo, Masayuki Ninomiya, Kaori Y. Tanaka, Robert J. Linhardt, Mamoru Koketsu · 2018 · Bioorganic & Medicinal Chemistry Letters
76. Colon-Targeted Delivery Facilitates the Therapeutic Switching of Sofalcone, a Gastroprotective Agent, to an Anticolitic Drug via Nrf2 Activation
    Wooseong Kim, Soo‐Jin Kim, Sanghyun Ju, Hanju Lee, Seongkeun Jeong, Jin‐Wook Yoo, In‐Soo Yoon, Yunjin Jung · 2019 · Molecular Pharmaceutics
77. (E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential
    Pablo Rayff da Silva, Maria de Almeida, Jamire Muriel da Silva, Sonaly Lima Albino, Renan Fernandes do Espírito Santo, Maria do Carmo Alves de Lima, Cristiane Flora Villarreal, Ricardo Olímpio de Moura, Vanda Lúcia dos Santos · 2020 · International Journal of Molecular Sciences
78. Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection
    Zi‐Long Song, Yanan Hou, Feifei Bai, Jianguo Fang · 2020 · Bioorganic Chemistry
79. Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response
    Amy Y. Sato, G Pellegrini, Meloney D. Cregor, Kevin McAndrews, Roy B. Choi, María Maiz, Olivia Johnson, Linda Doyle McCabe, George P. McCabe, Mário G. Ferruzzi et al. · 2020 · Journal of Bone and Mineral Research
80. Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses
    Agieshkumar Balakrishna Pillai, Aashika Raagavi JeanPierre, Vignesh Mariappan, Pajanivel Ranganadin, Rao S.R. · 2022 · Cell Stress and Chaperones
81. Terpenoids from Diplophyllum taxifolium with quinone reductase-inducing activity
    Xiao Wang, Jiao‐Zhen Zhang, Jinchuan Zhou, Tao Shen, Hong‐Xiang Lou · 2015 · Fitoterapia
82. Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-κB and JNK Activation in LPS-Stimulated BV2 Microglia
    Hsiou‐Yu Ding, Pei-Shan Wu, Ming‐Jiuan Wu · 2016 · International Journal of Molecular Sciences
83. Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction
    Barbara Cosimelli, Giovanni Greco, Sonia Laneri, Ettore Novellino, Antonia Sacchi, Giorgio Amendola, Sandro Cosconati, Roberta Bortolozzi, Giampietro Viola · 2019 · Journal of Enzyme Inhibition and Medicinal Chemistry
84. Pharmacological intervention in oxidative stress as a therapeutic target in neurological disorders
    Sudhanshu Sharma, Dia Advani, Ankita Das, Nishtha Malhotra, Akanksha Khosla, Vanshika Arora, Ankita Jha, Megha Yadav, Rashmi K. Ambasta, Pravir Kumar · 2021 · Journal of Pharmacy and Pharmacology
85. Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response
    Bhavana Chhunchha, Eri Kubo, Ronald R. Krueger, Dhirendra P. Singh · 2023 · Antioxidants
86. Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits
    Pinky Pinky, Neha Neha, Mubashshir Ali, Prachi Tiwari, Mohammad Mumtaz Alam, Haroonrashid M. Hattiwale, Azfar Jamal, Suhel Parvez · 2023 · Ageing Research Reviews
87. Camellia oil exhibits anti‐fatigue property by modulating antioxidant capacity, muscle fiber, and gut microbial composition in mice
    Shiying Huang, Huiyu Sun, Lin Dai, Xinjue Huang, R Chen, Minli Li, Jialing Huang, Fuchuan Guo · 2024 · Journal of Food Science
88. Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages
    Annika Lundqvist, Lisa U. Magnusson, Christina Ullström, Jeļena Krasiļņikova, Галина Телышева, Tatiana Dizhbite, Lillemor Mattsson Hultén · 2015 · Biochemical and Biophysical Research Communications
89. Propofol pretreatment attenuates remote kidney injury induced by orthotopic liver autotransplantation, which is correlated with the activation of Nrf2 in rats
    Mian Ge, Gangjian Luo, Weifeng Yao, Chenfang Luo, Shaoli Zhou, Dongdong Yuan, Xinjin Chi, Ziqing Hei · 2014 · Molecular Medicine Reports
90. Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors
    Angelo Sparaneo, Federico Pio Fabrizio, Annamaria la Torre, Paolo Graziano, Massimo Di Maïo, Andrea Fontana, Michele Bisceglia, Antônio Rossi, Stefano Pizzolitto, Giovanna De Maglio et al. · 2019 · International Journal of Molecular Sciences
91. Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2
    Jiaxin Wei, Chenye Mou, Yongjie Bao, Yanfei Xie, Haixiao Jin, Haowei Shen, Wenhua Zhou, Jinrong Zhang, Shan He, Bojun Chen et al. · 2021 · Journal of Functional Foods
92. The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies
    Federico Manai, Stefano M. Govoni, Marialaura Amadio · 2022 · Cells
93. Biological activity of selenorganic compounds at heavy metal salts intoxication
    N. Y. Rusetskaya, В. Б. Бородулин · 2015 · Biomeditsinskaya Khimiya
94. BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model
    Tetsushi Kataura, Shinji Saiki, Kei‐ichi Ishikawa, Wado Akamatsu, Yukiko Sasazawa, Nobutaka Hattori, Masaya Imoto · 2020 · Journal of Neurochemistry
95. Gamma-oryzanol alleviates osteoarthritis development by targeting Keap1–Nrf2 binding to interfere with chondrocyte ferroptosis
    Zi-Han Dai, Chen-Cheng Zhou, Caiyu Yu, Chengjie Qian, Shuqing Jin, Shi-qi Du, Yi-yun Lv, Chen Jin, Gang Zheng, Yu Zhan · 2024 · International Immunopharmacology
96. Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes
    Lorraine M. Deck, Lisa J. Whalen, Lucy A. Hunsaker, Robert E. Royer, David L. Vander Jagt · 2017 · Bioorganic & Medicinal Chemistry
97. CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways
    Shanshan Wang, Qian Luo, Yuefang Zhou, Peihong Fan · 2019 · ACS Omega
98. The Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in Glaucoma: A Review
    Mingxuan Wang, Jia Li, Yajuan Zheng · 2020 · Medical Science Monitor
99. Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐induced obesity treatment and induces immunometabolic changes in female mice and women
    Sébastien Le Garf, Brigitte Sibille, Isabelle Mothe‐Satney, Cyril Eininger, Philippe Fauque, Joseph Murdaca, Giulia Chinetti, Jaap G. Neels, Anne‐Sophie Rousseau · 2021 · The FASEB Journal
100. Investigating the effect of Sulforaphane on AMPK/AKT/NRF2 pathway in human granulosa-lutein cells under H2O2-induced oxidative stress
     Maryam Taheri, Nasim Hayati Roudbari, Fardin Amidi, Kazem Parivar · 2022 · European Journal of Obstetrics & Gynecology and Reproductive Biology