Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents

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1. Coupled molecular design diagrams to guide safer chemical design with reduced likelihood of perturbing the NRF2-ARE antioxidant pathway and inducing cytotoxicity
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2. Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test
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3. Design and synthesis of Osthole-based compounds as potential Nrf2 agonists
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4. An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells
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5. Design, Synthesis and Pharmacological Evaluation of N ‐Benzyl Linoleamide Analogues from Tropaeolum tuberosum as NF‐κB Inhibitors and Nrf2 Activators
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6. Luteolin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity through activation of Nrf2/Keap1 signaling
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7. Lactobacillus fermentum ZC529 Protects Intestinal Epithelial Barrier Integrity by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway
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8. Ganoderma lucidum polysaccharides target the gut-brain axis: Unveiling a novel mechanism for ameliorating aging-induced cognitive impairment and oxidative stress
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9. Direct small-molecule inhibitors of the Keap1-Nrf2 protein-protein interaction: Scaffold evolution, PROTAC strategies, and therapeutic implications
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10. Real-time analysis of dynamic compartmentalized GSH redox shifts and H2O2 availability in undifferentiated and differentiated cells
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11. Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives
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12. The Most Severe Paradigm of Early Cardiovascular Disease: Hutchinson-Gilford Progeria. Focus on the Role of Oxidative Stress
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13. NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
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14. Role of K-Loop Cysteine Residues in the Marburg Virus Protein VP24–Human Keap1 Complex
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15. Nrf2/HO-1 Mediated Antioxidant Activities, Cytotoxicity Analysis and LCESI/ MS Profiling of Eulophia nuda L.
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16. Familiar dermatologic drugs as therapies for COVID-19
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17. JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation
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18. Inflammatory response and oxidative stress attenuated by sulfiredoxin‑1 in neuron‑like cells depends on nuclear factor erythroid‑2‑related factor 2
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19. The oxidative stress-inflammation self-perpetuating cycle in multiple sclerosis: from mechanisms to emerging antioxidant strategies
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20. The Effects of Antioxidant Approved Drugs and Under Investigation Compounds with Potential of Improving Sleep Disorders and their Associated Comorbidities Associated with Oxidative Stress and Inflammation
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21. Lycopene regulates Nrf2 to Ameliorate Sulfamethoxazole -induced renal injury and apoptosis via inhibiting oxidative stress and Endoplasmic Reticulum stress
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22. Engineering piperlongumine-inspired analogs as Nrf2-dependent neuroprotectors against oxidative damage by an electrophilicity-based strategy
    Qi Wang, Lin Dong, Xuefeng Liu, Fang Dai, Xiaojie Jin, Bo Zhou · 2022 · Free Radical Biology and Medicine
23. Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury
    Xin Li, Yan Ning Qian, Wanling Shen, Shiying Zhang, Hui Han, Yu Zhang, Shuangmei Liu, Shaokun Lv, Xiuying Zhang · 2023 · Mediators of Inflammation
24. Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities
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25. SerpinA3 Promotes Myocardial Infarction in Rat and Cell-based Models
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26. Pap12-6: A host defense peptide with potent immunomodulatory activity in a chicken hepatic cell culture
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27. Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect
    Xiang Yan, Fusheng Zhao, Senfeng Zhang, Fang Lei, Wen Wang, Yu Zheng · 2019 · Environmental Toxicology and Pharmacology
28. Melatonin Improves H2O2-Induced Oxidative Stress in Sertoli Cells Through Nrf2-Keap1 Signaling Pathway
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29. Neuroprotective Effects of a 3-Amino Quinazoline Derivative via Keap1–Nrf2 Pathway Activation in an ICV-STZ-Induced Rat Model of Sporadic Alzheimer’s Disease
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30. Saroglitazar Mitigated Cyclophosphamide-Induced Testicular Injury: Crosstalk Between Oxidative Stress, Inflammation and Apoptosis
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31. Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver
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32. Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota
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33. Molecular and Cellular Mechanisms of Neuropathic Pain in Aging
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34. Shengqing Jiangzhuo capsule ameliorates diabetic nephropathy by improving Keap1/Nrf2 signaling pathway
    Yanna Yu, Min Li, Weijie Lai, Xin Dong, Shu Zhang, Liangyou Zhang, Gangyi Chen · 2024 · Journal of Pharmacy and Pharmacology
35. Brusatol increases chemotherapeutic drug efficacy in pancreatic ductal adenocarcinoma by suppressing Nrf2 signaling
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36. N-Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation
    Sou Hyun Kim, Min-Woo Kim, Doyoung Kwon, Jae Sung Pyo, Joo Hyun Kim, Jae‐Hwan Kwak, Young‐Suk Jung · 2021 · Molecules
37. Antioxidant Activity of Edible Isothiocyanates
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38. Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
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39. Omega-3 fatty acids upregulate Nrf2 expression and attenuate apoptosis, inflammation, and fibrosis in a rat model of cyclosporine-induced nephropathy
    Ji Young Lee, Young Ki Son, Mi Hwa Lee, Su Mi Lee, Seong Eun Kim, Won Suk An · 2023 · Kosin Medical Journal
40. Ozone Therapy in Wound Care
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41. Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxygenistein derivatives
    Xiaoting Geng, Jing-Jing TANG, Kunpeng Cheng, Yuantao Fu, Rong Hu, Jinrong Lu · 2017 · Chinese Journal of Natural Medicines
42. Fármacos de uso frecuente en dermatología como terapia para COVID-19
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43. Zerdeçalın Genel Sağlık Üzerine Etkileri
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44. Sasa borealis Ethanol Extract Protects PC12 Neuronal Cells against Oxidative Stress
    Min Hye Kang, Yun‐Jeong Ji, Yu Mi Han, Gwi Yeong Jang, Dong Hwi Kim, Jeong Hoon Lee, Geum‐Soog Kim, Su Ji Choi, Hyung Don Kim · 2022 · Applied Sciences
45. Andrographolide, a Diterpene from Andrographis paniculata, and its Influence on the Progression of Neurodegenerative Disorders
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46. CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition
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47. Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy
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48. Tiliroside from Potentilla chinensis attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2
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49. Suspect screening and effect evaluation for small-molecule agonists of the antioxidant response element pathway in fine particulate matter
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50. Investigating Holistic Natural Strategies for The Management of Huntington's Disease
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51. The NFE2L2 rs35652124 polymorphism and the risk of Parkinson’s disease
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52. Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37
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53. Progeria, atherosclerosis and clonal hematopoiesis: links and future perspectives
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54. Participation of ASK-1 in the cardiomyocyte-protective role of mechanical ventilation in a rat model of myocardial infarction
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55. Structural Conformers of (1,3-Dithiol-2-ylidene)ethanethioamides: The Balance between Thioamide Rotation and Preservation of Classical Sulfur–Sulfur Hypervalent Bonds
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56. Dexmedetomidine improves DM-induced oxidative stress injury to protect liver function through Nrf2 pathway.
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57. Activation of the nuclear factor erythroid 2-related factor 2-antioxidant response element signal in rats with diffuse axonal injury
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58. The Anticarcinogenic Properties of Brassica Vegetables
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59. Medicinal plants or bioactive components with antioxidant/anti-apoptotic effects as a potential therapeutic approach in heart failure prevention and management: a literature review
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60. Curcumin inhibits koi herpesvirus (KHV) replication via Nrf2-Keap1/ARE and NF-κB pathways in ornamental koi (Cyprinus carpio haematopterus)
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61. Drynachromoside A from Drynaria fortunei attenuates oxidative stress and fibrosis of diabetic nephropathy via activating Nrf2 in vitro and in vivo
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62. Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner
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63. Flavonoid-rich Phyla nodiflora fraction promotes Keap1 degradation and Nrf2/HO-1 activation to attenuate particulate matter–induced oxidative stress in human keratinocytes
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64. Chicoric acid prevents motor dysfunction in zebrafish Parkinson’s disease model through Nrf2-mediated antioxidant effect
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65. Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies
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66. Vonoprazan mitigates diethyl nitrosamine-induced acute liver injury in mice via modulating p-AMPK/ SIRT1/ PGC-1α and Keap1/Nrf2/HO-1 pathways
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67. Low concentrations of clarithromycin upregulate cellular antioxidant enzymes and phosphorylation of extracellular signal-regulated kinase in human small airway epithelial cells
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68. The Importance of the Redox Modulation in the Prevention and Treatment of Chronic Pulmonary Diseases
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69. Inflammatory process and oxidative/nitrative stress: in vivo study in mucopolysaccharidosis type IV A patients under long-term enzyme replacement therapy
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70. Phlorizin alleviates deltamethrin-induced oxidative stress in brine shrimp Artemia
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71. Nrf2 as a potential target for improving wound healing in the elderly
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72. Diallyl disulfide attenuates hydrogen peroxide-induced oxidative damage of ovine rumen epithelial cells through the nuclear factor erythroid-2 related factor 2 signaling pathway
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73. An Azomethine Derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2) Ameliorated 7,12-dimethylbenz(a)anthracene-induced Mammary Carcinoma through Nrf2-Keap1-HO-1 Pathway
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74. Cardiopulmonary injury in hypoxia and selenium: A review
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75. Nrf2 and Inflammation-Triggered Carcinogenesis
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76. Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives
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77. Association of polymorphisms in NFE2L2 gene encoding transcription factor Nrf2 with multifactorial diseases
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78. Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties
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79. Gene expression analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation
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80. Cytoprotection Activity Evaluation of (E)-3-(3,4-Dichlorophenyl)-1-(3,4-Dihydroxyphenyl)- Prop-2-En-1-One as a New Antioxidant Against H2O2-Induced Oxidative Damage in PC12 Cells
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81. Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Pharmacokinetic Evaluation of 7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranon in Rats
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82. Saprirearine protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis by activating Nrf2
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83. Avenanthramides
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84. FISETIN – A PROSPECTIVE NEUROPROTECTIVE AGENT WITH MULTI-MOLECULAR TARGET ‘S: A REVIEW
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85. Conserved Filovirus Proteins as Targets of Broad-Spectrum Antivirals
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86. Troglitazone as a Novel Nrf2 Activator to Attenuate Oxidative Stress and Exert Neuroprotection
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87. Sortase A inhibition: Updated review of non-peptide ligands for targeting Staphylococcus aureus virulence
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88. Exogenous Catalase Supplementation Alleviates Fusarium graminearum Mycotoxins-Induced Oxidative Stress in Weaned Piglets
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89. Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis
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90. Mechanistic and kinetic insights into the radical scavenging capacity and Keap1-Nrf2 inhibition potency of A-type avenanthramides: DFT and molecular docking
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91. Caenorhabditis elegans as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer’s Disease: Plant Bioactive Compounds and Therapeutic Translation
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92. Pro‐oxidants or anti‐oxidant defenses? Which one to blame in non‐alcoholic steatohepatitis pathogenesis?
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93. Discovery of 3-Amino-2-Hydroxypropoxyisoflavone Derivatives as Potential Anti-HCV Agents
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94. Small-Molecule Inhibitors of Protein–Protein Interactions as Therapeutics
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95. The Influence of Flavonoid Compositions on Nrf2 Transcription Factor Expression in Case of Infections Triggered by Influenza A Virus and Transmissible Gastroenteritis Coronavirus
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96. Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol‐induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway
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97. Potential Therapeutic Impacts of Curcumin Against Age-Related Impaired Cognition and Memory
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98. Regulation of Antioxidant Nrf2 Signaling: An Important Pathway in COPD
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99. Induction of Sirtuin1 Activity in SH-SY5Y Cells by Cyanidin-3-O-Glucocide Induced
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100. Targeting Nrf2 in inflammation and cancer
     Jonathan Cowan · 2014 · UEA Digital Repository (University of East Anglia)