Small Molecule Modulators of K eap1‐ N rf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents

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7. Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function
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8. Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol
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9. New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
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11. Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes
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12. Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes
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13. Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease
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14. Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
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15. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart
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17. Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara
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18. Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
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19. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease
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21. Nrf2 Modulation in Breast Cancer
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25. FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway
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27. Reversing ROS‐mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2‐ARE signaling pathway
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28. Exploring the target scope of KEAP1 E3 ligase-based PROTACs
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29. Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor
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30. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage
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31. Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages
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32. Mitochondria-Centric Review of Polyphenol Bioactivity in Cancer Models
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34. Quinones as Neuroprotective Agents
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35. New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular Signal-Transduction Processes
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36. Cytoprotection “gone astray’’: Nrf2 and its role in cancer
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37. Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds
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38. Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells
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39. Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases
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40. “NRF2 addiction” in lung cancer cells and its impact on cancer therapy
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41. Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway
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42. Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants
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43. Active form of vitamin D analogue mitigates neurodegenerative changes in Alzheimer’s disease in rats by targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways
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44. New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications
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45. A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells
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46. Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors
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47. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
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48. Direct inhibition of Keap1–Nrf2 interaction by egg-derived peptides DKK and DDW revealed by molecular docking and fluorescence polarization
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49. Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking
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50. Luteolin Modulates 6-Hydroxydopamine-Induced Transcriptional Changes of Stress Response Pathways in PC12 Cells
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51. Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target
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52. Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: A novel approach to activate Nrf2 function
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53. Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency
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54. Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349
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55. Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis — A review
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56. Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
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57. Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
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58. The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma
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59. Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy
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60. Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection
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61. Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice
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62. CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies
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63. Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma
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64. The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects
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65. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways
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67. Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation
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68. Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart
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69. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells
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70. Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
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71. Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology
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72. Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication
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75. Ginger Oleoresin Alleviated γ‐Ray Irradiation‐Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells
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76. Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes
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77. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress
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78. Antioxidative and antibacterial gallium (III)-phenolic coating for enhanced osseointegration of titanium implants via pro-osteogenesis and inhibiting osteoclastogenesis
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79. Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
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80. Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
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81. Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As Inhibition of COX-2 Activity
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82. Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects
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86. Nrf2: bane or blessing in cancer?
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87. 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress
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88. Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease
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89. Differential Impact of Flavonoids on Redox Modulation, Bioenergetics, and Cell Signaling in Normal and Tumor Cells: A Comprehensive Review
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90. Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds
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91. Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway
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92. Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs
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93. Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases
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94. Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
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95. Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.
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96. Role of puerarin in pathological cardiac remodeling: A review
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97. Activation of the Phase II Enzymes for Neuroprotection by Ginger Active Constituent 6-Dehydrogingerdione in PC12 Cells
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98. Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells
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99. Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships
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100. A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis
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