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The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Emerging use of senolytics and senomorphics against aging and chronic diseases

Martel, Jan, Ojcius, David M., Wu, Cheng‐Yeu, Peng, Hsin‐Hsin, Voisin, Laurent, Perfettini, Jean‐Luc, Ko, Yun‐Fei, Young, John D.·2020·Medicinal Research Reviews
DOI 10.1002/med.21702
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Abstract

Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

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Crossref · 10.1002/med.21702

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37 of 37 references verified0 citation errors · 0 not checkable

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  • Multiple interventions, acting at different levels, can delay or even reverse the aging process.

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    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [12]

  • The long-term impact of interventions on whole organisms is still poorly understood.

    “Such interventions have been successful in reducing cell damage and preserving tissue health, but the long-term impact on whole organisms is still poorly understood [11][12][13][14] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [12]

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Metadata

Authors
Martel, J., Ojcius, D. M., Wu, C., Peng, H., Voisin, L., Perfettini, J., Ko, Y., & Young, J. D.
Venue
Medicinal Research Reviews
Publisher
Wiley
Published
2020-06-24
Volume
40
Issue
6
Pages
2114-2131
ISSN
  • 0198-6325
  • 1098-1128
DOI
10.1002/med.21702
Cited by
127
References
37
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Primordia Institute of New Sciences and Medicine

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