Resveratrol Attenuates Oxidative Damage and Ameliorates Cognitive Impairment in the Brain of Senescence-Accelerated Mice
Abstract
Aims Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM).Main methods Senescence-accelerated mice were administered with Res (25, 50, 100mg·kg(-1)·d(-1)) for 8weeks. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the content of malondialdehyde (MDA) in mice brain were determined. The gene expression of SOD in mice brain was investigated by real time reverse transcriptase-polymerase chain reaction (RT-PCR).Key findings The results showed that resveratrol significantly improved learning and memory ability in Morris water maze test and neuromuscular coordination and sensorimotor capacity in tightrope test. Meanwhile, Res increased the activities of antioxidant enzymes with a reduction in lipid peroxidation. And real time RT-PCR analysis also indicated that the change of SOD mRNA was the same as the modification of SOD activity in mice brain. Furthermore, Res could prevent cerebral mitochondrial DNA deletions which might be one of the causes resulting in learning and memory impairment.Significance These results suggest that the pharmacological action of Res may offer a novel therapeutic strategy for the treatment of age-related conditions.
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RSV can reduce oxidative damage in the brain of aged mice by increasing levels of SOD and plasma GPx, decreasing malondialdehyde, and lowering expression of pro-inflammatory proteins (IL1β and TNFα) in old mice, as well as in patients with coronary artery disease.
“It has been demonstrated that RSV can reduce oxidative damage in the brain of aged mice by increasing the levels of SOD and plasma GPx, decreasing malondialdehyde, and lowering the expression of several pro-inflammatory proteins (IL1β and tumour necrosis factor α) in old mice, as well as in patients with coronary artery disease [321,322].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [321]
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- Authors
- Liu, G.-S., Zhang, Z.-S., Yang, B., & He, W.
- Affiliations
- Ningxia University (CN)
- Tianjin University of Science and Technology (CN)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 91
- Issue
- 17-18
- Pages
- 872-877
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2044184576
- Cited by
- 82
- References
- 33
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 8
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the People's Republic of China (20101208110001)
- Program for Changjiang Scholars and Innovative Research Team in University (IRT1166)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, Polygonum cuspidatum, senescence-accelerated mice, cognitive impairment, oxidative stress, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, lipid peroxidation, mitochondrial DNA deletions, learning and memory, neuroprotection, aging
- MeSH terms
- Resveratrol, Aging, Animals, Antioxidants, Brain, Cognition Disorders, DNA, Mitochondrial, Glutathione Peroxidase, Male, Malondialdehyde, Memory, RNA, Messenger, Stilbenes, Superoxide Dismutase, Gene Deletion, Oxidative Stress, Maze Learning, Fallopia japonica, Mice
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