Understanding the tumor microenvironment for effective immunotherapy

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198

Understanding the tumor immune microenvironment (TIME) for effective therapy

Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400

Immune Checkpoint Inhibitors in Cancer Therapy

Shiravand, Y., Khodadadi, F., Kashani, S. M. A., Hosseini-Fard, S. R., Hosseini, S., Sadeghirad, H., Ladwa, R., O’Byrne, K., & Kulasinghe, A. (2022) · Current Oncology · doi:10.3390/curroncol29050247 · Cited by 1,353

Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications

Muhammad, P., Zada, A., Rashid, J., Hanif, S., Gao, Y., Li, C., Li, Y., Fan, K., & Wang, Y. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202314686 · Cited by 374

Targeting the Warburg Effect in Cancer: Where Do We Stand?

Barba, I., Carrillo-Bosch, L., & Seoane, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063142 · Cited by 276

The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis

Güven, D. C., Şahin, T. K., Erul, E., Rizzo, A., Ricci, A. D., Aksoy, S., & Yalçın, Ş. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1039121 · Cited by 220

A comprehensive review of immune checkpoint inhibitors for cancer treatment

Hossain, M. A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113365 · Cited by 213

Targeting of TAMs: can we be more clever than cancer cells?

Kzhyshkowska, J. G., Shen, J., & Larionova, I. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01232-z · Cited by 187

Immunotherapy in Breast Cancer

Dvir, K., Giordano, S. B., & Leone, J. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147517 · Cited by 184

Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering

Chen, A., Wang, W., Mao, Z., He, Y., Chen, S., Liu, G., Su, J. D., Feng, P., Shi, Y., Yan, C., et al. (2023) · Advanced Materials · doi:10.1002/adma.202307686 · Cited by 160

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

Glaviano, A., Lau, H., Carter, L. M., Lee, E. H. C., Lam, H. Y., Okina, E., Tan, D. J. J., Tan, W., Ang, H. L., Carbone, D., et al. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01634-6 · Cited by 169

Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer

Liu, L., Mo, M., Chen, X., Chao, D., Zhang, Y., Chen, X., Wang, Y., Zhang, N., He, N., Yuan, X., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02647-8 · Cited by 91

Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

Yang, Z., Tian, H., Chen, X., Li, B., Bai, G., Cai, Q., Xu, J., Guo, W., Wang, S., Peng, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52977-0 · Cited by 85

The Complex Tumor Microenvironment in Ovarian Cancer: Therapeutic Challenges and Opportunities

Garlisi, B., Lauks, S., Aitken, C., Ogilvie, L. M., Lockington, C., Petrik, D., Eichhorn, J. S., & Petrik, J. (2024) · Current Oncology · doi:10.3390/curroncol31070283 · Cited by 91

Targeting of the tumor microenvironment by curcumin

Fu, X., He, Y., Li, M., Huang, Z., & Najafi, M. (2021) · BioFactors · doi:10.1002/biof.1776 · Cited by 79

Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer

Tong, P., Yang, J., Zhou, Y.-F., Tang, Y., Tang, M.-T., Zang, Y., Pan, Y., Dong, L., Tan, Y., Nam, K. T., et al. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216381 · Cited by 72

Crosstalk between metabolism and cell death in tumorigenesis

Yang, S., Hu, C., Chen, X., Tang, Y., Li, J., Yang, H., Yang, Y., Ying, B., Xiao, X., Li, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01977-1 · Cited by 71

Comprehensive Pan-Cancer Analysis of KIF18A as a Marker for Prognosis and Immunity

Liu, T., Yang, K. Y., Chen, J., Qi, L.-M., Zhou, X., & Wang, P. (2023) · Biomolecules · doi:10.3390/biom13020326 · Cited by 62

Artificial Intelligence-Assisted Score Analysis for Predicting the Expression of the Immunotherapy Biomarker PD-L1 in Lung Cancer

Cheng, G., Zhang, F., Xing, Y., Hu, X., Zhang, H., Chen, S., Li, M., Peng, C., Ding, G., Zhang, D., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.893198 · Cited by 65

The interactions of docetaxel with tumor microenvironment

Gupta, R., Kadhim, M. M., Jalil, A. T., Alasheqi, M. Q., Alsaikhan, F., Mukhamedova, N. K., Ramírez‐Coronel, A. A., Jawhar, Z. H., Ramaiah, P., & Najafi, M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110214 · Cited by 65

Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer

Haider, M. A., Elsherbeny, A., Pittalà, V., Fallica, A. N., Alghamdi, M. A., Hussain, Z., Khoder, G., & Greish, K. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031853 · Cited by 62

Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions

Mandal, K., Barik, G. K., & Santra, M. K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02400-z · Cited by 69

Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation by Natural Products

Lafta, H. A., AbdulHussein, A. H., Al-Shalah, S. A. J., Alnassar, Y. S., Mohammed, N. M., Akram, S. M., Qasim, M. T., & Najafi, M. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230201145909 · Cited by 61

Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis

Shu, J., Jiang, J., & Zhao, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1177847 · Cited by 57

Immune checkpoint inhibitors associated cardiovascular immune-related adverse events

Jo, W., Won, T., Daoud, A., & Čiháková, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1340373 · Cited by 55

Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment

Aden, D., Sureka, N., Zaheer, S., Chaurasia, J. K., & Zaheer, S. (2024) · Immunology · doi:10.1111/imm.13871 · Cited by 58

Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma

Zhang, T., Lei, X., Jia, W., Li, J., Nie, Y., Mao, Z., Wang, Y., Tao, K., & Song, W. (2022) · Cancer Medicine · doi:10.1002/cam4.5227 · Cited by 53

Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer

Qi, Y., Yao, Q., Li, X., Li, X., Zhang, W., & Qu, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-44681-8 · Cited by 52

Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance

Xiao, Y., Hassani, M., Moghaddam, M. B., Fazilat, A., Ojarudi, M., & Valilo, M. (2025) · Medical Oncology · doi:10.1007/s12032-025-02675-8 · Cited by 58

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Zheng, J., Jiang, J., Pu, Y., Xu, T., Sun, J., Zhang, Q., He, L., & Liang, X. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1248421 · Cited by 52

Understanding the tumor microenvironment in head and neck squamous cell carcinoma

Sadeghirad, H., Shiravand, Y., Radfar, P., Ladwa, R., Perry, C., Han, X., Warkiani, M. E., Adams, M. N., Hughes, B. G. M., O'Byrne, K. J., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1397 · Cited by 52

Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment

Wang, L., Gu, M., Zhang, X., Kong, T., Liao, J., Zhang, D., & Li, J. (2025) · Advanced Science · doi:10.1002/advs.202413367 · Cited by 47

Nanotechnology in leukemia therapy: revolutionizing targeted drug delivery and immune modulation

Bishoyi, A. K., Nouri, S., Hussen, A., Bayani, A., Khaksari, M. N., & Samarkhazan, H. S. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01686-z · Cited by 48

Aggregable gold nanoparticles for cancer photothermal therapy

Wu, M., Xiao, Y., Wu, R., Lei, J., Li, T. X., & Zheng, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00403e · Cited by 44

The Role of Circulating Biomarkers in Lung Cancer

Herath, S., Sadeghirad, H., Radfar, P., Ladwa, R., Warkiani, M. E., O'Byrne, K. J., & Kulasinghe, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.801269 · Cited by 47

Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies

Luo, H., Ma, W., Chen, Q., Yáng, Z., & Dai, Y. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102042 · Cited by 44

Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer

Monkman, J. H., Kim, H., Mayer, A. T., Mehdi, A. M., Matigian, N., Cumberbatch, M., Bhagat, M., Ladwa, R., Mueller, S. N., Adams, M. N., et al. (2023) · Immunology · doi:10.1111/imm.13646 · Cited by 44

Advances in Targeted and Chemotherapeutic Strategies for Colorectal Cancer: Current Insights and Future Directions

Shaham, S. H., Vij, P., & Tripathi, M. K. (2025) · Biomedicines · doi:10.3390/biomedicines13030642 · Cited by 47

Modelling the tumor immune microenvironment for precision immunotherapy

Mackenzie, N. J., Nicholls, C., Templeton, A. R., Perera, O. M., Jeffery, P. L., Zimmermann, K., Kulasinghe, A., Kenna, T., Vela, I., Williams, E. D., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1400 · Cited by 45

A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma

Shirazi, A. Z., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., Yaghoobi, M., Ormsby, R. J., Poonnoose, S. I., Tumes, D. J., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01394-x · Cited by 40

Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy

Jin, Z., Sun, X., Wang, Y., Zhou, C., Yang, H., & Zhou, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1018903 · Cited by 39

Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy

Cong, X., Chen, J., & Xu, R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.916952 · Cited by 40

Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy

Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37

Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy

Sadeghirad, H., Liu, N., Monkman, J. H., Ma, N., Cheikh, B. B., Jhaveri, N., Tan, C. W., Warkiani, M. E., Adams, M. N., Nguyen, Q. H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1135489 · Cited by 35

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions

Kamaraj, R., Ghosh, S., Das, S., Sen, S., Kumar, P. R., Majumdar, M., Dasgupta, R., Mukherjee, S., Das, S., Ghose, I., et al. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00253 · Cited by 37

Emerging role of circulating tumor cells in immunotherapy

Rzhevskiy, A. S., Kapitannikova, A. Y., Malinina, P., Volovetsky, A. B., Es, H. A., Kulasinghe, A., Thiery, J. P., Maslennikova, A., Zvyagin, A. V., & Warkiani, M. E. (2021) · Theranostics · doi:10.7150/thno.59677 · Cited by 39

Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images

Patkar, S., Chen, A., Basnet, A., Bixby, A., Rajendran, R., Chernet, R., Faso, S., Kumar, P. A., Desai, D., El-Zammar, O., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00765-w · Cited by 41

Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies

Guo, Y., Gao, F., Ahmed, A. R., Rafiq, M., Yu, B., Cong, H., & Shen, Y. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01358h · Cited by 38

Deciphering head and neck cancer microenvironment: Single‐cell and spatial transcriptomics reveals human papillomavirus‐associated differences

Lee, H., Park, S., Yun, J. H., Seo, C., Ahn, J. M., Cha, H., Shin, Y. S., Park, H. R., Lee, D., Roh, J., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29386 · Cited by 36

Ultrasmall silica nanoparticles in translational biomedical research: Overview and outlook

Singh, N., Shi, S., & Goel, S. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114638 · Cited by 35

Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response

Sadeghirad, H., Monkman, J. H., Tan, C. W., Liu, N., Yunis, J., Donovan, M. L., Moradi, A., Jhaveri, N., Perry, C., Adams, M. N., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05409-y · Cited by 35

Prodrug nanoparticles potentiate tumor chemo-immunometabolic therapy by disturbing oxidative stress

Zhao, H., Li, Y., Shi, H., Niu, M., Li, D., Zhang, Z., Feng, Q., Zhang, Y., & Wang, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.011 · Cited by 33

Advances in landscape and related therapeutic targets of the prostate tumor microenvironment

Li, D., Xu, W., Chang, Y. E., Xiao, Y., He, Y., & Ren, S. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023092 · Cited by 37

mRNA vaccines in tumor targeted therapy: mechanism, clinical application, and development trends

Gao, Y., Yang, L., Li, Z., Peng, X., & Li, H. (2024) · Biomarker Research · doi:10.1186/s40364-024-00644-3 · Cited by 34

The Road to Precision Nanomedicine: An Insight on Drug Repurposing and Advances in Nanoformulations for Treatment of Cancer

Elmahboub, Y., Albash, R., Ahmed, S., & Salah, S. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03233-1 · Cited by 32

Single-Cell Profiling Reveals Heterogeneity of Primary and Lymph Node Metastatic Tumors and Immune Cell Populations and Discovers Important Prognostic Significance of CCDC43 in Oral Squamous Cell Carcinoma

Wang, Z., Zhang, H., Zhai, Y., Li, F., Shi, X., & Ying, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843322 · Cited by 33

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

Lalani, A. R., Fakhari, F., Radgoudarzi, S., Rastegar‐Pouyani, N., Moloudi, K., Khodamoradi, E., Taeb, S., & Najafi, M. (2023) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13760 · Cited by 33

AFF3 is a novel prognostic biomarker and a potential target for immunotherapy in gastric cancer

Zeng, Y., Zhang, X., Li, F., Wang, Y., & Wei, M. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24437 · Cited by 30

Reprogramming cellular senescence in the tumor microenvironment augments cancer immunotherapy through multifunctional nanocrystals

Wang, Z., Chen, Y., Fang, H., Xiao, K., Wu, Z., Xie, X., Liu, J., Chen, F., He, Y., Wang, L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp7022 · Cited by 35

The Immune Contexture of Liposarcoma and Its Clinical Implications

Resag, A., Toffanin, G., Benešová, I., Müller, L., Potkrajcic, V., Ozaniak, A., Lischke, R., Bartůňková, J., Rosato, A., Jöhrens, K., et al. (2022) · Cancers · doi:10.3390/cancers14194578 · Cited by 30

NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Bonine, N., Zanzani, V., Hemelryk, A. V., Vanneste, B., Zwicker, C., Thoné, T., Roelandt, S., Bekaert, S.-L., Köster, J., Janoueix‐Lerosey, I., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114804 · Cited by 29

Targeting tumor microenvironment for non-small cell lung cancer immunotherapy

Wang, L., Jia, Q., Chu, Q., & Zhu, B. (2023) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2022.11.001 · Cited by 30

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach

Adhikary, S., Pathak, S., Palani, V., Acar, A., Banerjee, A., Al-Dewik, N. I. E., Essa, M. M., Mohammed, S. G. A. A., & Qoronfleh, M. W. (2024) · Biomedicines · doi:10.3390/biomedicines12010217 · Cited by 28

Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma

Chen, K., Wang, Q., Liu, X., Wang, F., Ma, Y., Zhang, S., Shao, Z., Yang, Y., & Tian, X. (2022) · Genes · doi:10.3390/genes13101760 · Cited by 26

Extracellular vesicle-based macromolecule delivery systems in cancer immunotherapy

Chen, H., Sun, T., & Jiang, C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.014 · Cited by 25

High-Throughput immunogenetics for precision medicine in cancer

Agathangelidis, A., Vlachonikola, E., Davi, F., Langerak, A. W., & Chatzidimitriou, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.10.009 · Cited by 25

KIF2C is a Biomarker Correlated With Prognosis and Immunosuppressive Microenvironment in Human Tumors

Zhang, X., Li, Y., Hu, P., Xu, L., & Qiu, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.891408 · Cited by 25

Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer

Zhang, E., Ding, C., Li, S., Aikemu, B., Zhou, X., Fan, X., Sun, J. P., Yang, X. Y., & Zheng, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02892-z · Cited by 26

The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses

Chun, J., Park, S., Lee, M., Ha, I. J., & Jeong, M.-K. (2023) · Cancers · doi:10.3390/cancers15030653 · Cited by 23

Advancements in Single‐Cell Proteomics and Mass Spectrometry‐Based Techniques for Unmasking Cellular Diversity in Triple Negative Breast Cancer

Nalla, L. V., Kanukolanu, A., Yeduvaka, M., & Gajula, S. N. R. (2024) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202400101 · Cited by 23

Recent advances in biomarkers for predicting the efficacy of immunotherapy in non-small cell lung cancer

Zhang, J., Song, Z., Zhang, Y., Zhang, C., Xue, Q., Zhang, G., & Tan, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1554871 · Cited by 25

Immunotherapeutic targets in non‐small cell lung cancer

Sadeghirad, H., Bahrami, T., Layeghi, S. M., Yousefi, H., Rezaei, M., Hosseini‐Fard, S. R., Radfar, P., Warkiani, M. E., O'Byrne, K. J., & Kulasinghe, A. (2022) · Immunology · doi:10.1111/imm.13562 · Cited by 24

Phytocompounds-based therapeutic approach: Investigating curcumin and green tea extracts on MCF-7 breast cancer cell line

Fawzy, R. M., AbdEl-Aziz, A., Bassiouny, K., & Fayed, A. M. (2024) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2023.100339 · Cited by 23

Pediatric Solid Cancers: Dissecting the Tumor Microenvironment to Improve the Results of Clinical Immunotherapy

Belgiovine, C., Mebelli, K., Raffaele, A., Cicco, M. D., Rotella, J., Pedrazzoli, P., Zecca, M., Riccipetitoni, G., & Comoli, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063225 · Cited by 22

Natural products as promising modulators of breast cancer immunotherapy

Alqathama, A. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1410300 · Cited by 21

The Pandora’s box of novel technologies that may revolutionize lung cancer

Sadeghirad, H., Rad, H. S., Shiravand, Y., Radfar, P., Arpon, D. R., Warkiani, M. E., O'Byrne, K. J., & Kulasinghe, A. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.06.022 · Cited by 21

The main battlefield of mRNA vaccine – Tumor immune microenvironment

Li, X., Ma, S., Gao, T., Mai, Y., Song, Z., & Yang, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109367 · Cited by 22

Immune Checkpoint Inhibitors and Lupus Erythematosus

von Eckstaedt, H. V., Singh, A., Reid, P. D., & Trotter, K. C. (2024) · Pharmaceuticals · doi:10.3390/ph17020252 · Cited by 20

Insights into the Relationship Between the Gut Microbiome and Immune Checkpoint Inhibitors in Solid Tumors

Čierniková, S., Ševčíková, A., Novisedláková, M., & Mego, M. (2024) · Cancers · doi:10.3390/cancers16244271 · Cited by 20

Tailored therapies for triple-negative breast cancer: current landscape and future perceptions

Khan, Y., Rizvi, S., Raza, A., Khan, A., Hussain, M. S., Khan, N. U., Alshammari, S. O., Alshammari, Q. A., Alshammari, A., & Ellakwa, D. E. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03896-4 · Cited by 21

Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues

Rothzerg, E., Feng, W., Song, D., Li, H., Wei, Q., Fox, A. H., Wood, D., Xu, J., & Liu, Y. (2022) · Cancer Informatics · doi:10.1177/11769351221140101 · Cited by 20

Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy

Nenkov, M., Shi, Y. H., Ma, Y., Gaßler, N., & Chen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010006 · Cited by 23

Progress of Immune Checkpoint Inhibitors Therapy for pMMR/MSS Metastatic Colorectal Cancer

Qu, F., Wu, S., & Yu, W. (2024) · OncoTargets and Therapy · doi:10.2147/ott.s500281 · Cited by 20

Immune checkpoint inhibitors and immunosuppressive tumor microenvironment: current challenges and strategies to overcome resistance

Gill, G. S., Kharb, S., Goyal, G., Das, P., Kurdia, K. C., Dhar, R., & Karmakar, S. (2025) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2025.2504906 · Cited by 19

Advances in Stimuli‐Responsive Release Strategies for Sonosensitizers in Synergistic Sonodynamic Immunotherapy against Tumors

Ding, R., Yang, H., Wang, J., Liu, Y., Mu, S., Wang, D., & Li, J. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502183 · Cited by 19

Carrier-Free Nanomedicine for Cancer Immunotherapy

Fu, Y., Bian, X., Li, P., Huang, Y., & Li, C. (2022) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2022.3315 · Cited by 19

CircRNA Regulation of T Cells in Cancer: Unraveling Potential Targets

Li, Z., Yin, S., Yang, K., Zhang, B., Wu, X., Zhang, M., & Gao, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126383 · Cited by 19

Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses

Cao, J., Zhang, C., Jiang, G., Jin, S., Wang, Q., Wang, A., & Bai, D. (2020) · Bioengineered · doi:10.1080/21655979.2020.1868119 · Cited by 19

Research advances on the immune research and prospect of immunotherapy in pituitary adenomas

Nie, D., Fang, Q., Li, B., Cheng, J., Li, C., Gui, S., Zhang, Y., & Zhao, P. (2021) · World Journal of Surgical Oncology · doi:10.1186/s12957-021-02272-9 · Cited by 18

Spatial profiling technologies and applications for brain cancers

Croft, P. K., Sadeghirad, H., Gasper, H. M., O'Byrne, K. J., Lakhani, S. R., & Kulasinghe, A. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1900735 · Cited by 18

The Aging-Related Prognostic Signature Reveals the Landscape of the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

Chen, F., Gong, X., Meng, X., Feng, Y., Wu, J., Yu, C., & Li, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.857994 · Cited by 17

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Li, H., Zu, X., Hu, J., Xiao, Z., Cai, Z., Gao, N., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.964393 · Cited by 16

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Zhou, X., Chen, B., Zhang, Z., Huang, Y., Li, J., Wei, Q., Cao, D., & Ai, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113258 · Cited by 18

Reprogramming tumor-associated macrophages using exosomes from M1 macrophages

Mahmoudi, M., Taghavi-Farahabadi, M., Hashemi, S. M., Mousavizadeh‬, K., Rezaei, N., & Mojtabavi, N. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150697 · Cited by 17

Battlegrounds of treatment resistance: decoding the tumor microenvironment

Bayat, M., & Nahand, J. S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04055-5 · Cited by 17

Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems

Perra, M., Castangia, I., Aroffu, M., Fulgheri, F., Rached, R. A., Manca, M. L., Cortés, H., Prado-Audelo, M. L. D., Nomura-Contreras, C. A., Romero‐Montero, A., et al. (2025) · Discover Oncology · doi:10.1007/s12672-025-01820-z · Cited by 16

Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with Wilms tumour

Tian, X., Xiang, B., Jin, L., Mi, T., Wang, J.-K., Zhanghuang, C., Zhang, Z., Chen, M., Shi, Q., Liu, F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.920666 · Cited by 16

CD8+ Cell Density Gradient across the Tumor Epithelium–Stromal Interface of Non-Muscle Invasive Papillary Urothelial Carcinoma Predicts Recurrence-Free Survival after BCG Immunotherapy

Drachneris, J., Rasmusson, A., Morkūnas, M., Fabijonavicius, M., Čekauskas, A., Jankevičius, F., & Laurinavičius, A. (2023) · Cancers · doi:10.3390/cancers15041205 · Cited by 15

Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironment

Wang, P., Wang, X., Man, C., Gong, D., & Fan, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1200619 · Cited by 17

AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection

Chen, Z., Xie, T., Chen, S., Li, Z., Yao, S., Lü, X., He, W., Tang, C., Yang, D., Li, S., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101270 · Cited by 15

The latest applications of exosome-mediated drug delivery in anticancer therapies

Wen, Z., Zhang, W., & Wu, W. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114500 · Cited by 15

Navigate Towards the Immunotherapy Era: Value of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer Patients With Brain Metastases

Yang, G., Xing, L., & Sun, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852811 · Cited by 15

The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies

Sadeghirad, H., Bazaz, S. R., Monkman, J. H., Warkiani, M. E., Rezaei, N., O'Byrne, K. J., & Kulasinghe, A. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1215 · Cited by 37

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Zhang, Y., & Liu, Z. (2025) · Advanced Science · doi:10.1002/advs.202508692 · Cited by 13

Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses

Oliver, A. J., Lau, P. K. H., Unsworth, A., Loi, S., Darcy, P. K., Kershaw, M. H., & Slaney, C. Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00070 · Cited by 169

Role of tumor microenvironment in regulator of tumor progression and immunotherapy

周平平 (2026) · Discover Oncology · doi:10.1007/s12672-026-04421-6 · Cited by 4

Research Progress on the Regulation of Tumor Microenvironment in Immunotherapy

Ren, J., Xie, W., & Zhang, H. (2025) · Journal of Contemporary Medical Practice · doi:10.53469/jcmp.2025.07(04).51