Cited by 35Nanoparticle-Based Drug DeliveryNanotechnology research and applicationsNanoparticles: synthesis and applications

Ultrasmall silica nanoparticles in translational biomedical research: Overview and outlook

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Singh, Neetu, Shi, Sixiang, Goel, Shreya·2023·Advanced Drug Delivery Reviews

Abstract

The exemplary progress of silica nanotechnology has attracted extensive attention across a range of biomedical applications such as diagnostics and imaging, drug delivery, and therapy of cancer and other diseases. Ultrasmall silica nanoparticles (USNs) have emerged as a particularly promising class demonstrating unique properties that are especially suitable for and have shown great promise in translational and clinical biomedical research. In this review, we discuss synthetic strategies that allow precise engineering of USNs with excellent control over size and surface chemistry, functionalization, and pharmacokinetic and toxicological profiles. We summarize the current state-of-the-art in the biomedical applications of USNs with a particular focus on select clinical studies. Finally, we illustrate long-standing challenges in the translation of inorganic nanotechnology, particularly in the context of ultrasmall nanomedicines, and provide our perspectives on potential solutions and future opportunities in accelerating the translation and widespread adoption of USN technology in biomedical research.

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Crossref · 10.1016/j.addr.2022.114638

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  • Nanoparticle radiopharmaceuticals allow co-delivery of therapeutic agents, contrast agents, or multiple radiotracers.

    “These platforms allow the co-delivery of therapeutic agents, contrast agents, or multiple radiotracers, creating finely tuned symphonies of treatment and imaging tailored to individual patient profiles [81].”

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Authors
Singh, N., Shi, S., & Goel, S.
Affiliations
University of Utah (US)
Corresponding author
  • Shi, Sixiang
  • Goel, Shreya
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2023-01
Volume
192
Pages
114638
ISSN
0169-409X (ISSN-L)
OpenAlex
W4311094710
Cited by
35
References
131
Citations by year
2026: 4 · 2025: 13 · 2024: 11 · 2023: 7
FWCI
0.53
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (acceptedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P30CA042014)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
nanomedicine, translational research, nanoparticle synthesis, surface functionalization, pharmacokinetics, nanotoxicology, drug delivery, cancer therapy, biomedical imaging
MeSH terms
Humans, Silicon Dioxide, Biomedical Research, Nanotechnology, Nanomedicine, Nanoparticles

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