The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanisms of hypolipidemic and anti‐obesity effects of tea and tea polyphenols
Abstract
Among the health‐promoting effects of tea and tea polyphenols, the cancer‐chemopreventive effects in various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food research. It has been demonstrated that the body weights of rats and their plasma triglyceride, cholesterol, and LDL‐cholesterol have been significantly reduced by feedings of oolong, black, pu‐erh, and green tea leaves to the animals. It has been suggested that the inhibition of growth and suppression of lipogenesis in MCF‐7 breast cancer cells may be through down‐regulation of fatty acid synthase gene expression in the nucleus and stimulation of cell energy expenditure in the mitochondria. The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down‐regulation of EGFR/PI3K/Akt/Sp‐1 signal transduction pathways.
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Cites
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089
Cited by
Tea Polyphenols for Health Promotion
Khan, N., & Mukhtar, H. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.06.011 · Cited by 1,156
Beneficial effects of green tea: A literature review
Chacko, S. M., Thambi, P. T., Kuttan, R., & Nishigaki, I. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-13 · Cited by 987
Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619
Tea and its consumption: Benefits and risks
Hayat, K., Iqbal, H., Malik, U., Bilal, U., & Mushtaq, S. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.678949 · Cited by 405
Araghizadeh, A., Kohanteb, J., & Fani, M. M. (2013) · Medical Principles and Practice · doi:10.1159/000348299 · Cited by 345
Metadata
- Authors
- Lin, J., & Lin‐Shiau, S.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2006-02
- Volume
- 50
- Issue
- 2
- Pages
- 211-217
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2172122060
- Cited by
- 301
- References
- 3
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, J., & Lin‐Shiau, S. (2006). Mechanisms of hypolipidemic and anti‐obesity effects of tea and tea polyphenols. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200500138
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