Tea Polyphenols for Health Promotion
Open accessAbstract
People have been consuming brewed tea from the leaves of the Camellia sinensis plant for almost 50 centuries. Although health benefits have been attributed to tea, especially green tea consumption since the beginning of its history, scientific investigations of this beverage and its constituents have been underway for less than three decades. Currently, tea, in the form of green or black tea, next to water, is the most widely consumed beverage in the world. In vitro and animal studies provide strong evidence that polyphenols derived from tea may possess the bioactivity to affect the pathogenesis of several chronic diseases. Among all tea polyphenols, epigallocatechin-3-gallate has been shown to be responsible for much of the health promoting ability of green tea. Tea and tea preparations have been shown to inhibit tumorigenesis in a variety of animal models of carcinogenesis. However, with increasing interest in the health promoting properties of tea and a significant rise in scientific investigation, this review covers recent findings on the medicinal properties and health benefits of tea with special reference to cancer and cardiovascular diseases.
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The 1H NMR signals in the ethanolic extracts are characteristic of aromatic protons typically found in flavonoids and polyphenolic compounds such as flavones and chalcones.
“These signals are characteristic of aromatic protons, which are typically found flavonoids and polyphenolic compounds, such as flavones and chalcones [39,40,41].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [41]
The Introduction describes ring structures in tea catechins and lists flavonols, but it does not interpret ¹H NMR signals from ethanolic extracts. Searches for aromatic-proton signals, flavones, and chalcones found no passage addressing the claimed spectral assignment. The paper’s discussion of polyphenols alone does not verify that assignment. (LLM, conf=0.72)
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Tea and its consumption: Benefits and risks
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“Pharmacological research focuses mainly on the polyphenols of tea due to their antioxidant, anticancer properties,[1] nevertheless, tea drinkers experience the immediate effect of two other compounds: Both caffeine and theanine exert their activities on the central nervous system.”
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- Authors
- Khan, N., & Mukhtar, H.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Mukhtar, Hasan
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 81
- Issue
- 7
- Pages
- 519-533
- ISSN
- 0024-3205 (ISSN-L)
- PMC
- PMC3220617
- OpenAlex
- W2000519650
- Cited by
- 1,156
- References
- 123
- Citations by year
- 2026: 37 · 2025: 52 · 2024: 60 · 2023: 54 · 2022: 69 · 2021: 61 · 2020: 65 · 2019: 66 · 2018: 66 · 2017: 71 · 2016: 64 · 2015: 56 · 2014: 71 · 2013: 90 · 2012: 81
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service
- National Cancer Institute (R01CA101039, R01CA 78809, R01CA078809, R01CA120451)
- National Institute of Diabetes and Digestive and Kidney Diseases (P50DK065303)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- tea polyphenols, Camellia sinensis, green tea, black tea, epigallocatechin gallate, health promotion, cancer prevention, cardiovascular disease, tumorigenesis inhibition, chronic disease pathogenesis
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Biotransformation, Diabetes Mellitus, Epidemiologic Methods, Flavonoids, Health Promotion, Histamine Antagonists, Humans, Longevity, Obesity, Phenols, Tea, Anticarcinogenic Agents, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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