The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Induction of cell apoptosis in 3T3‐L1 pre‐adipocytes by flavonoids is associated with their antioxidant activity
Abstract
Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3‐L1 pre‐adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC ROO value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time‐ and dose‐dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time‐ and dose‐dependent increase in the caspase‐3 activity. Western analysis indicated that treatment of quercetin markedly down‐regulated PARP and Bcl‐2 proteins, and activated caspase‐3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3‐L1 pre‐adipocytes.
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Apoptosis in the Pathogenesis and Treatment of Disease
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.011 · Cited by 290
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Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Ahn, J., Lee, H., Kim, S., Park, J., & Ha, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.077 · Cited by 522
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Quercetin and metabolic syndrome: A review
Hosseini, A., Razavi, B. M., Banach, M., & Hosseinzadeh, H. (2021) · Phytotherapy Research · doi:10.1002/ptr.7144 · Cited by 386
Flavonoids as Antiobesity Agents: A Review
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Metadata
- Authors
- Hsu, C., & Yen, G.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2006-10-30
- Volume
- 50
- Issue
- 11
- Pages
- 1072-1079
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2040640228
- Cited by
- 165
- References
- 5
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hsu, C., & Yen, G. (2006). Induction of cell apoptosis in 3T3‐L1 pre‐adipocytes by flavonoids is associated with their antioxidant activity. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200600040
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