The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
Abstract
Cancer chemoprevention involves the use of natural or synthetic compounds to reduce the risk of developing cancer. One of the potential strategies for preventing cancer in the human population is to use food-based natural products to induce cytoprotective enzymes, such as NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase, superoxide dismutase, and heme oxygenase-1. The regulatory regions of these inducible genes contain the antioxidant response element (ARE), which is activated upon binding of the nuclear factor E2-related protein 2 (Nrf2) transcription factor protein. Nrf2 has been shown to be essential in the upregulation of these genes in response to oxidative stress and treatment with certain dietary phytochemicals. This review presents the current body of knowledge regarding the molecular mechanisms of Nrf2 regulation, and highlights the need for future investigations into how these mechanisms apply to natural product inducers of cytoprotective enzymes.
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Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947
Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480 · cited 6×
“2B), show these cysteines are required for efficient ubiquitination and basal inhibition of Nrf2 in cell culture [16], and these cysteines may play a role as well in sensing of ARE inducers.”
InfluentialDysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060
Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2887-2900.2006 · Cited by 759 · cited 1×
“2A) that mediate binding to the Keap1 Kelch repeats [20, 21].”
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · cited 2×
“Interestingly, recent studies have found somatic mutations in the KEAP1 gene in human lung cancer cells, which result in increased activity of Nrf2 and higher levels of ARE-regulated genes [81, 82].”
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
Liby, K. T., Yore, M. M., & Sporn, M. B. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2129 · Cited by 637 · cited 1×
“While the effects of chemopreventive agents are likely pleotropic in nature [63, 64], there is a large body of evidence accumulating that induction of cytoprotective enzymes by chemopreventive agents through the Nrf2 pathway will be an important and viable part of preventing cancer in the human population.”
Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., & Pickett, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207293200 · Cited by 615
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
Tong, K. I., Kobayashi, A., Katsuoka, F., & Yamamoto, M. (2006) · Biological Chemistry · doi:10.1515/bc.2006.164 · Cited by 473 · cited 3×
“For instance, is the observed ARE activation by genistein [57] due mainly to its ability to inhibit phosphorylation of Nrf2 Y568 by Src kinases, or is it also acting at the level of downregulating Nrf2 ubiquitination? Furthermore, might other natural product–ARE inducers similar in structure to genistein act primarily…”
Cited by
Surh, Y.-J., Kundu, J., & Na, H.-K. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 758
Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760
Renoprotective effect of the antioxidant curcumin: Recent findings
Trujillo, J., Chirino, Y. I., Molina-Jijón, E., Andérica-Romero, A. C., Tapia, E., & Pedraza-Chaverrí, J. (2013) · Redox Biology · doi:10.1016/j.redox.2013.09.003 · Cited by 566
Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy
Laszczyk, M. (2009) · Planta Medica · doi:10.1055/s-0029-1186102 · Cited by 489
Williams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448
Metadata
- Authors
- Eggler, A. L., Gay, K. A., & Mesecar, A. D.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2008-04-24
- Volume
- 52 Suppl 1
- Pages
- S84-94
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1978373182
- Cited by
- 235
- References
- 9
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008). Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200700249
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