Cited by 49Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismFatty Acid Research and Health

Regulation of genes involved in lipid metabolism by dietary oxidized fat

Ringseis, Robert, Eder, Klaus·2011·Molecular Nutrition & Food Research

Abstract

Although oxidized fats are widely considered to have detrimental effects on human health, a large number of feeding studies with experimental animals have consistently demonstrated that oxidized fats, compared with fresh fats, cause a reduction in the concentrations of triacylglycerols and cholesterol in liver and plasma. The reason for these effects became clear when recently it was shown that thermo-oxidized fats contain characteristic substances such as hydroxylated fatty acids and cyclic fatty acid monomers which are potent ligands and activators of peroxisome proliferator-activated receptor α - a transcription factor controlling genes involved in fatty acid and lipoprotein metabolism. In addition, oxidized fats have also been reported to inhibit expression of genes involved in fatty acid synthesis and cholesterol homeostasis. These effects are mediated by inhibiting the maturation of sterol regulatory-element binding proteins, which are transcription factors regulating genes involved in fatty acid synthesis and cholesterol homeostasis. This review summarizes the phenotypical alterations of lipid metabolism observed in feeding studies dealing with oxidized fats and addresses the molecular mechanisms underlying these lipid metabolism alterations, in particular the lipid lowering effects of dietary oxidized fats.

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Crossref · 10.1002/mnfr.201000424

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Authors
Ringseis, R., & Eder, K.
Affiliations
Justus-Liebig-Universität Gießen (DE)
Corresponding author
Ringseis, Robert
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2010-11-18
Volume
55
Issue
1
Pages
109-121
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2131955003
Cited by
49
References
78
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 5
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
oxidized fats, lipid metabolism, PPARα, hydroxy fatty acids, SREBP, cholesterol homeostasis, fatty acid synthesis, triglycerides, lipoprotein metabolism, gene expression regulation
MeSH terms
Animals, Cholesterol, Dietary Fats, Fatty Acids, Gene Expression Regulation, Humans, Liver, Oxidation-Reduction, Transcription Factors, Triglycerides, PPAR alpha, Lipogenesis, Lipid Metabolism

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