Regulation of genes involved in lipid metabolism by dietary oxidized fat
Abstract
Although oxidized fats are widely considered to have detrimental effects on human health, a large number of feeding studies with experimental animals have consistently demonstrated that oxidized fats, compared with fresh fats, cause a reduction in the concentrations of triacylglycerols and cholesterol in liver and plasma. The reason for these effects became clear when recently it was shown that thermo-oxidized fats contain characteristic substances such as hydroxylated fatty acids and cyclic fatty acid monomers which are potent ligands and activators of peroxisome proliferator-activated receptor α - a transcription factor controlling genes involved in fatty acid and lipoprotein metabolism. In addition, oxidized fats have also been reported to inhibit expression of genes involved in fatty acid synthesis and cholesterol homeostasis. These effects are mediated by inhibiting the maturation of sterol regulatory-element binding proteins, which are transcription factors regulating genes involved in fatty acid synthesis and cholesterol homeostasis. This review summarizes the phenotypical alterations of lipid metabolism observed in feeding studies dealing with oxidized fats and addresses the molecular mechanisms underlying these lipid metabolism alterations, in particular the lipid lowering effects of dietary oxidized fats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Serum TG is first hydrolyzed, liberating FFA during TG catabolism.
“Serum TG is first hydrolyzed, which liberates FFA during TG catabolism26.”
From Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial (2015) · cites this paper as [26]
Cites
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116 · see citing works
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,902 · see citing works
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,342 · see citing works
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11041 · Cited by 1,327 · see citing works
Peroxisome proliferator-activated receptor a target genes
Mandard, S., M�ller, M., & Kersten, S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3216-3 · Cited by 1,222 · see citing works
Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works
Crucial Step in Cholesterol Homeostasis
Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987 · see citing works
Guthrie, J. F., Lin, B.-H., & Frazao, E. (2002) · Journal of Nutrition Education and Behavior · doi:10.1016/s1499-4046(06)60083-3 · Cited by 973 · see citing works
Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7473 · Cited by 943 · see citing works
Shimomura, I., Shimano, H., Horton, J. D., Goldstein, J. L., & Brown, M. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119247 · Cited by 760 · see citing works
Yabe, D., Brown, M. S., & Goldstein, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162488899 · Cited by 557 · see citing works
Peroxisome proliferator-activated receptor $gamma; in diabetes and metabolism
Rangwala, S. M., & Lazar, M. A. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.03.012 · Cited by 456 · see citing works
Maternal Lipid Metabolism and Placental Lipid Transfer
Herrera, E., Amusquivar, E., López‐Soldado, I., & Ortega, H. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091507 · Cited by 322 · see citing works
Fischer, M., You, M., Matsumoto, M., & Crabb, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302140200 · Cited by 291 · see citing works
Goldstein, J. L., Rawson, R. B., & Brown, M. S. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2615 · Cited by 250 · see citing works
Peroxisome proliferator-activated receptor-α and liver cancer: where do we stand?
Peters, J. M., Cheung, C., & Gonzalez, F. J. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0678-9 · Cited by 248 · see citing works
Holden, P. R., & Tugwood, J. D. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0220001 · Cited by 202 · see citing works
Oxidized phospholipids activate PPARα in a phospholipase A2‐dependent manner
Delerive, P., Furman, C., Teissier, E., Fruchart, J., Duriez, P., & Staels, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01364-8 · Cited by 200 · see citing works
Holst, D., Luquet, S. H., Nogueira, V., Kristiansen, K., Leverve, X. M., & Grimaldi, P. A. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00071-4 · Cited by 193 · see citing works
Oxidized Omega-3 Fatty Acids Inhibit NF-κB Activation Via a PPARα-Dependent Pathway
Mishra, A., Chaudhary, A. K., & Sethi, S. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137191.02577.86 · Cited by 188 · see citing works
Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
Espenshade, P. J., Li, W.-P., & Yabe, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182412799 · Cited by 159 · see citing works
Guallar‐Castillón, P., Rodríguez‐Artalejo, F., Fornés, N. S., Banegas, J. R., Etxezarreta, P. A., Ardanáz, E., Barricarte, A., Chirlaque, M., Iraeta, M. D., Larrañaga, N., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.198 · Cited by 149 · see citing works
Crabb, D. W., Galli, A., Fischer, M., & You, M. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.005 · Cited by 143 · see citing works
Long-term Rat Feeding Study with Used Frying Fats
Nolen, G. A., Alexander, J. C., & Artman, N. R. (1967) · Journal of Nutrition · doi:10.1093/jn/93.3.337 · Cited by 118 · see citing works
Sébédio, J. L., & Grandgirard, A. (1989) · Progress in Lipid Research · doi:10.1016/0163-7827(89)90003-9 · Cited by 116 · see citing works
König, B., Koch, A. H., Spielmann, J., Hilgenfeld, C., Stangl, G. I., & Eder, K. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.10.027 · Cited by 112 · see citing works
Self-citationEffect of ingestion of thermally oxidized frying oil on peroxidative criteria in rats
IZAKI, Y., Yoshikawa, S., & Uchiyama, M. (1984) · Lipids · doi:10.1007/bf02534782 · Cited by 106 · see citing works
Effect of Maternal Polyunsaturated Fatty Acid Concentration on Transport by the Human Placenta
Haggarty, P., Ashton, J., Joynson, M., Abramovich, D. R., & Page, K. (1999) · Neonatology · doi:10.1159/000014115 · Cited by 103 · see citing works
Chao, P., Chao, C., Lin, F., & Huang, C.-J. (2001) · Journal of Nutrition · doi:10.1093/jn/131.12.3166 · Cited by 102 · see citing works
van Vlies, N., Ferdinandusse, S., Turkenburg, M., Wanders, R. J. A., & Vaz, F. M. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.07.001 · Cited by 98 · see citing works
Liu, J., & Huang, C. (1995) · Journal of Nutrition · doi:10.1093/jn/125.12.3071 · Cited by 94 · see citing works
Thermally Oxidized Dietary Fat Upregulates the Expression of Target Genes of PPARα in Rat Liver
Sülzle, A., Hirche, F., & Eder, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.6.1375 · Cited by 91 · see citing works
Self-citationThe effects of a dietary oxidized oil on lipid metabolism in rats
Eder, K. (1999) · Lipids · doi:10.1007/s11745-999-0418-0 · Cited by 85 · see citing works
Self-citationBull, A. W. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg131 · Cited by 81 · see citing works
Liu, J., & Lee, Y.-W. (1998) · Journal of Nutrition · doi:10.1093/jn/128.1.116 · Cited by 81 · see citing works
Cheon, Y., Nara, T., Band, M. R., Beever, J. E., Wallig, M. A., & Nakamura, M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00751.2004 · Cited by 78 · see citing works
Muga, S. J., Thuillier, P., Pavone, A., Rundhaug, J. E., Boeglin, W. E., Jisaka, M., BRASH, A. R., & Fischer, S. M. (2000) · PubMed · Cited by 76 · see citing works
König, B., Koch, A. H., Spielmann, J., Hilgenfeld, C., Hirche, F., Stangl, G. I., & Eder, K. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.009 · Cited by 75 · see citing works
Self-citationEffects of deteriorated frying oil and dietary protein levels on liver microsomal enzymes in rats
Huang, C.-J., Cheung, N., & Lu, V. (1988) · Journal of the American Oil Chemists Society · doi:10.1007/bf02542385 · Cited by 72 · see citing works
Wen, G., Ringseis, R., & Eder, K. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.10.002 · Cited by 67 · see citing works
Self-citationKoch, A., König, B., Stangl, G. I., & Eder, K. (2008) · Experimental Biology and Medicine · doi:10.3181/0706-rm-168 · Cited by 61 · see citing works
Self-citationRingseis, R., Muschick, A., & Eder, K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.77 · Cited by 55 · see citing works
Self-citationEder, K., & Kirchgeßner, M. (1998) · Lipids · doi:10.1007/s11745-998-0206-x · Cited by 52 · see citing works
Self-citationRingseis, R., Piwek, N., & Eder, K. (2007) · Inflammation Research · doi:10.1007/s00011-006-6122-y · Cited by 52 · see citing works
Self-citationLiu, J., & Huang, C. (1996) · Journal of Nutrition · doi:10.1093/jn/126.9.2227 · Cited by 50 · see citing works
Luci, S., König, B., Giemsa, B., Huber, S., Hause, G., Kluge, H., Stangl, G. I., & Eder, K. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507669256 · Cited by 49 · see citing works
Self-citationEffect of Dietary Vitamin E on the Toxicity of Autoxidized Oil to Rats
Yoshida, H., & KAJIMOTO, G. (1989) · Annals of Nutrition and Metabolism · doi:10.1159/000177532 · Cited by 48 · see citing works
Luci, S., Giemsa, B., Kluge, H., & Eder, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00603.2006 · Cited by 47 · see citing works
Self-citationEder, K., Suelzle, A., Skufca, P., Brandsch, C., & Hirche, F. (2003) · Lipids · doi:10.1007/s11745-003-1028-6 · Cited by 46 · see citing works
Self-citationPoling, C. E., Eagle, E., Rice, E. E., Durand, A. M., & Fisher, M. (1970) · Lipids · doi:10.1007/bf02531107 · Cited by 46 · see citing works
Chao, P., Huang, H.-L., Liao, C.-H., Huang, S.-T., & Huang, C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450769000x · Cited by 44 · see citing works
König, B., & Eder, K. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.08.011 · Cited by 44 · see citing works
Self-citationEder, K., Keller, U., Hirche, F., & Brandsch, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2830 · Cited by 44 · see citing works
Self-citationKoch, A. H., König, B., Spielmann, J., Leitner, A., Stangl, G. I., & Eder, K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.9.2018 · Cited by 43 · see citing works
Self-citationHayam, I., Cogan, U., & Mokady, S. (1993) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(93)90024-q · Cited by 42 · see citing works
Ammouche, A., Rouaki, F., Bitam, A., & Bellal, M. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000066496 · Cited by 37 · see citing works
Eder, K., & Stangl, G. I. (2000) · Journal of Nutrition · doi:10.1093/jn/130.1.116 · Cited by 36 · see citing works
Self-citationRingseis, R., Gutgesell, A., Dathe, C., Brandsch, C., & Eder, K. (2007) · Lipids in Health and Disease · doi:10.1186/1476-511x-6-6 · Cited by 36 · see citing works
Self-citationPeffer, P. A. L., Lin, X., & Odle, J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00822.2004 · Cited by 35 · see citing works
Ringseis, R., Dathe, C., Muschick, A., Brandsch, C., & Eder, K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.9.2056 · Cited by 33 · see citing works
Self-citationChao, P., Hsu, S., Lin, F., Li, Y., & Huang, C. (2004) · Lipids · doi:10.1007/s11745-004-1224-4 · Cited by 32 · see citing works
Koch, A. H., König, B., Luci, S., Stangl, G. I., & Eder, K. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450775691x · Cited by 31 · see citing works
Self-citationPeroxisome Proliferation in Liver of Rats Fed Oxidized Frying Oil
Chao, P., Yang, M.-F., Tseng, Y.-N., Chang, K.-M., Lu, K., & Huang, C.-J. (2005) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.51.361 · Cited by 29 · see citing works
Keller, U., Brandsch, C., & Eder, K. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0481-3 · Cited by 25 · see citing works
Self-citationBrandsch, C., & Eder, K. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041195 · Cited by 23 · see citing works
Self-citationMartin, J., Caselli, C., Broquet, S., Juanéda, P., Nour, M., Sébédio, J. L., & Bernard, A. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37185-6 · Cited by 23 · see citing works
Brandsch, C., Naß, N., & Eder, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.631 · Cited by 22 · see citing works
Self-citationEder, K., Skufca, P., & Brandsch, C. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1275 · Cited by 21 · see citing works
Self-citationKämmerer, I., Ringseis, R., & Eder, K. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003478 · Cited by 18 · see citing works
Self-citationEder, Keller, & Brandsch (2004) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.74.1.11 · Cited by 17 · see citing works
Benedetti, C., Felice, M. D., Gentili, V., Tagliamonte, B., & Tomassi, G. (1990) · Annals of Nutrition and Metabolism · doi:10.1159/000177591 · Cited by 16 · see citing works
Heated canola oil and oxidative stress in rats
Kok, T. S., Harris, P., & Alexander, J. C. (1988) · Nutrition Research · doi:10.1016/s0271-5317(05)80081-8 · Cited by 15 · see citing works
Skufca, P., Brandsch, C., Hirche, F., & Eder, K. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000070487 · Cited by 11 · see citing works
Self-citationBrétillon, L., Alexson, S. E. H., Joffre, F., Pasquis, B., & Sébédio, J. (2003) · Lipids · doi:10.1007/s11745-003-1149-y · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Possible adverse effects of frying with vegetable oils
Dobarganes, C., & Márquez‐Ruiz, G. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514002347 · Cited by 113 · see citing works
Limiting factors for milk production in dairy cows: perspectives from physiology and nutrition
Gross, J. J. (2022) · Journal of Animal Science · doi:10.1093/jas/skac044 · Cited by 75 · see citing works
Na, L., Zhang, Q., Jiang, S., Du, S., Zhang, W., Li, Y., Sun, C., & Niu, Y. (2015) · Scientific Reports · doi:10.1038/srep10344 · Cited by 74 · see citing works
Hoang, M.-H., Jia, Y., Jun, H., Lee, J. H., Hwang, K.-Y., Choi, D., Um, S., Lee, B., You, S., & Lee, S. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100611 · Cited by 62 · see citing works
Li, X., Yu, X., Sun, D., Li, J., Wang, Y., Cao, P., & Liu, Y. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04565 · Cited by 57 · see citing works
Li, T., Zhu, R., Dong, Y., Liu, Y., Li, S., & Chen, G. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400283w · Cited by 53 · see citing works
Ross, J. S., Hu, W. M., Rosen, B. P., Snider, A. J., Obeid, L. M., & Cowart, L. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477786 · Cited by 53 · see citing works
Interleukin-6 signal transduction and its role in hepatic lipid metabolic disorders
Hassan, W., Ding, L., Gao, R.-Y., Liu, J., & Shang, J. (2014) · Cytokine · doi:10.1016/j.cyto.2013.12.017 · Cited by 52 · see citing works
From Food to Genes: Transcriptional Regulation of Metabolism by Lipids and Carbohydrates
Bravo-Ruiz, I., Medina, M. Á., & Martı́nez-Poveda, B. (2021) · Nutrients · doi:10.3390/nu13051513 · Cited by 51 · see citing works
Kämmerer, I., Ringseis, R., Biemann, R., Wen, G., & Eder, K. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-222 · Cited by 50 · see citing works
Self-citationSun, D., Zhang, L., Chen, H., Feng, R., Cao, P., & Liu, Y. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0601-8 · Cited by 50 · see citing works
Plant-Based Foods as a Source of Lipotropes for Human Nutrition: A Survey of In Vivo Studies
Fardet, A., & Chardigny, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.549596 · Cited by 46 · see citing works
Revol-Cavalier, J., Quaranta, A., Newman, J. W. I., BRASH, A. R., Hámberg, M., & Wheelock, C. E. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00520 · Cited by 44 · see citing works
Ringseis, R., Keller, J., & Eder, K. (2018) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12959 · Cited by 44 · see citing works
Self-citationFatty acid metabolism: Implications for diet, genetic variation, and disease
Suburu, J., Gu, Z., Chen, H., Chen, W., Zhang, H., & Chen, Y. Q. (2013) · Food Bioscience · doi:10.1016/j.fbio.2013.07.003 · Cited by 43 · see citing works
Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
Varady, J., Geßner, D. K., Most, E., Eder, K., & Ringseis, R. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-31 · Cited by 43 · see citing works
Self-citationLee, Y., Kim, S., Yuk, H. J., Lee, G., & Kim, D.-S. (2018) · Nutrients · doi:10.3390/nu10081087 · Cited by 37 · see citing works
Dong, G., Zhu, X., Ren, H., Nie, B., Chen, L., Li, H., & Yan, B. (2013) · Aquaculture Research · doi:10.1111/are.12138 · Cited by 35 · see citing works
Ding, L., Liu, J.-L., Hassan, W., Wang, L., Yan, F., & Shang, J. (2014) · Scientific Reports · doi:10.1038/srep04715 · Cited by 30 · see citing works
Metabolomics reveals the toxicological effects of polar compounds from frying palm oil
Yuan, L., Jiang, F., Cao, X., Liu, Y., & Xu, Y. (2020) · Food & Function · doi:10.1039/c9fo02728a · Cited by 24 · see citing works
Zhou, L., Ding, X., Wang, J., Bai, S., Zeng, Q., Su, Z., Xuan, Y., Wu, A., & Zhang, K. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2685310 · Cited by 24 · see citing works
Chronic consumption of thermally processed palm oil or canola oil modified gut microflora of rats
Ruan, M., Bu, Y., Wu, F., Zhang, S., Chen, R., Li, N., Liu, Z., & Wang, H. (2020) · Food Science and Human Wellness · doi:10.1016/j.fshw.2020.06.005 · Cited by 21 · see citing works
Pignitter, M., Zaunschirm, M., Lach, J., Unterberger, L., Kopic, A., Keßler, C., Kienesberger, J., Pischetsrieder, M., Eggersdorfer, M. L., Riegger, C., et al. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8766 · Cited by 20 · see citing works
Yuan, J., Kerr, B. J., Curry, S. M., & Chen, C. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00451-4 · Cited by 19 · see citing works
Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice
Li, Y., Li, J., Cao, P., & Liu, Y. (2020) · RSC Advances · doi:10.1039/d0ra00215a · Cited by 19 · see citing works
Lee, Y. M., Jin, B., Lee, S. Y., Song, M., Bae, H., Min, B., Park, J., Lee, D., & Kim, H. (2016) · Molecules · doi:10.3390/molecules21111424 · Cited by 17 · see citing works
Araújo, B. C., Salini, M., Glencross, B. D., & Wade, N. M. (2016) · Aquaculture Research · doi:10.1111/are.13215 · Cited by 15 · see citing works
Effects of epoxy stearic acid on lipid metabolism in HepG2 cells
Liu, Y., Li, J., & Liu, Y. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15405 · Cited by 15 · see citing works
Zhang, L., Li, C., Wang, F., Zhou, S., MingJun, S., Xue, L.-N., Zhang, B., FuXiang, D., Hui, D., Liang, A., et al. (2015) · PPAR Research · doi:10.1155/2015/347245 · Cited by 13 · see citing works
Varady, J., Ringseis, R., & Eder, K. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-34 · Cited by 11 · see citing works
Self-citationWang, L., Yao, D., Urriola, P. E., Hanson, A. R., Saqui–Salces, M., Kerr, B. J., Shurson, G. C., & Chen, C. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.009 · Cited by 11 · see citing works
Hasanpour, S., Sheikhzadeh, N., Jamali, H., Farsani, M. N., & Mardani, K. (2019) · Journal of Applied Ichthyology · doi:10.1111/jai.13960 · Cited by 11 · see citing works
Zaunschirm, M., Pignitter, M., Kopic, A., Keßler, C., Hochkogler, C. M., Kretschy, N., Somoza, M. M., & Somoza, V. (2019) · Molecules · doi:10.3390/molecules24224111 · Cited by 11 · see citing works
Potential adverse health effects of dietary lipid oxidation products
Hu, Y., Zhao, G., Zhang, M., Zhou, D., & Zhu, B. (2021) · Journal of Food Bioactives · doi:10.31665/jfb.2021.15282 · Cited by 10 · see citing works
Suk, F., Hsu, F.-Y., Lee, Y., Chen, T.-L., Chiu, W., & Liao, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109267 · Cited by 10 · see citing works
Effects of deep frying vegetable oils rich in PUFAs on gut microbiota in rats
Ruan, M., Zhang, Z., Yuan, X., Zhou, R., Zhang, S., Tian, Y. T., Li, X., Li, N., Liu, Z., Zhu, R., et al. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16158 · Cited by 9 · see citing works
Coz, J. L., Ilic, S., Fibi-Smetana, S., Schatzmayr, G., Zaunschirm, M., & Grenier, B. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.650732 · Cited by 7 · see citing works
Li, X., Liu, Y., Xu, Y., & Liu, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104193 · Cited by 7 · see citing works
Yong, A. S. K., Mubarak, N. S. S., Zhuo, L.-C., Lin, Y.-H., & Shapawi, R. (2022) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2022.837469 · Cited by 6 · see citing works
Shang, W., Si, X., Strappe, P., Zhou, Z., & BLANCHARD, C. L. (2017) · RSC Advances · doi:10.1039/c7ra08855h · Cited by 5 · see citing works
Jaiswar, D., Jeeyar, V., Choudhury, S., & Dixit, M. (2026) · Cancer Control · doi:10.1177/10732748261433619 · Cited by 4 · see citing works
Interaction of Genetic Factors With Nutrition in Cancer
Freudenheim, J. L., & Gower, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00033-3 · Cited by 4 · see citing works
Yousaf, M., Aziz, U., Rehman, A., Waqar, M., Ali, N. S., Khan, N., Mohsin, M., Maarij, M. Y., Mushahid, M., & An, X. (2026) · Small Animal Advances · doi:10.58803/saa.v5i1.47 · Cited by 1 · see citing works
Nutrition and Genetic Factors in Carcinogenesis
Freudenheim, J. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00034-2 · Cited by 1 · see citing works
Eljasik, P., Panicz, R., Sobczak, M., Sadowski, J., & Ostaszewska, T. (2020) · Turkish Journal of Fisheries and Aquatic Sciences · doi:10.4194/1303-2712-v20_12_06 · Cited by 1 · see citing works
Brown, R. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-40458-5_29 · Cited by 1 · see citing works
Mainwaring, L. A. (2012) · Cardiff Metropolitan Research Repository (Cardiff Metropolitan University) · doi:10.25401/cardiffmet.20496210
Nutrition and Metabolism of Fried Foods
Zeb, A. (2019) · Wiley eBooks · doi:10.1002/9781119468417.ch9
Yuan, J., Kerr, B. J., Curry, S. M., & Chen, C. (2020) · Figshare · doi:10.6084/m9.figshare.12269912
- Authors
- Ringseis, R., & Eder, K.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Corresponding author
- Ringseis, Robert
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-11-18
- Volume
- 55
- Issue
- 1
- Pages
- 109-121
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2131955003
- Cited by
- 49
- References
- 78
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- oxidized fats, lipid metabolism, PPARα, hydroxy fatty acids, SREBP, cholesterol homeostasis, fatty acid synthesis, triglycerides, lipoprotein metabolism, gene expression regulation
- MeSH terms
- Animals, Cholesterol, Dietary Fats, Fatty Acids, Gene Expression Regulation, Humans, Liver, Oxidation-Reduction, Transcription Factors, Triglycerides, PPAR alpha, Lipogenesis, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review