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Cited by 39Skin Protection and AgingPhytochemicals and Antioxidant ActivitiesNonmelanoma Skin Cancer Studies

Dietary proanthocyanidins inhibit UV radiation‐induced skin tumor development through functional activation of the immune system

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Katiyar, Santosh K.·2016·Molecular Nutrition & Food Research
DOI 10.1002/mnfr.201501026PMC PMC4899090
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Abstract

The incidence of skin cancer is equivalent to the incidence of malignancies in all other organs combined. The main risk factor for this disease is overexposure of the skin to solar ultraviolet (UV) radiation. UV irradiation induces inflammation, oxidative stress, DNA damage, and suppression of the immune system in the skin, which together contribute to carcinogenesis. The use of dietary phytochemicals shows great promise as a complementary and alternative strategy for skin cancer prevention. Grape seed proanthocyanidins (GSPs) have been tested extensively for their anti‐skin cancer effect using in vivo animal models. Supplementation of an AIN76A control diet with GSPs (0.2 and 0.5%, w/w) significantly inhibits UV radiation‐induced skin tumor development as well as malignant transformation of papillomas to carcinoma in mice. The inhibition of UVB‐induced skin tumor development by GSPs is mediated through interrelated mechanisms of action including: (i) inhibition of inflammation, (ii) rapid repair of damaged DNA, and (iii) stimulation of immune system. Additionally, the chemopreventive effects of GSPs involve DNA repair‐dependent functional activation of antigen‐presenting cells and stimulation of CD8+ effector T cells. These effects of GSPs could be useful in attenuation of the adverse effects of UV radiation and may have health benefits in humans.

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  • In SKH-1 hairless mice, addition of grape seed proanthocyanidins to a standard diet effectively inhibited photocarcinogenesis, as evidenced by reduced tumor incidence, decreased tumor multiplicity and smaller tumor sizes.

    “In SKH-1 hairless mice, the addition of grape seed proanthocyanidins to a standard diet effectively inhibited photocarcinogenesis, as evidenced by reduced tumor incidence, decreased tumor multiplicity and smaller tumor sizes (Katiyar 2016).”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Katiyar 2016

  • Grape seed proanthocyanidins resulted in prevention of the malignant progression of UV-B-induced papillomas to carcinomas.

    “Grape seed proanthocyanidins also resulted in the prevention of the malignant progression of UV-B-induced papillomas to carcinomas.”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Katiyar 2016

  • When human skin was topically treated with green tea polyphenols before exposure to ultraviolet radiation, a dose-dependent inhibition of cyclobutane pyrimidine dimer formation was observed.

    “Similarly, when human skin was topically treated with green tea polyphenols before exposure to ultraviolet radiation, a dose-dependent inhibition of cyclobutane pyrimidine dimer formation was observed (Katiyar 2016).”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Katiyar 2016

    The Introduction identifies green tea polyphenols as having anti-skin-carcinogenic activity, but does not describe topical treatment of human skin or a dose-dependent effect on CPD formation. Section 4.2 discusses CPDs after dietary grape-seed proanthocyanidins in mice, a different treatment and population. Searches for topical green tea treatment and dose-dependent CPD inhibition found no passage addressing the claimed observation. (LLM, conf=0.74)

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Authors
Katiyar, S. K.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Katiyar, Santosh K.
ORCID
Katiyar, Santosh K.
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2016-04-13
Volume
60
Issue
6
Pages
1374-1382
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
DOI
10.1002/mnfr.201501026
PMC
PMC4899090
OpenAlex
W2300954986
Cited by
39
References
2
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 3
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute/NIH (CA104428, 1I01BX001410)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Keywords
proanthocyanidins, grape seed proanthocyanidins, ultraviolet radiation, skin cancer, chemoprevention, immune activation, antigen-presenting cells, CD8+ T cells, DNA repair, inflammation, oxidative stress, dietary phytochemicals
MeSH terms
Animals, Antigen-Presenting Cells, Biological Availability, Diet, Disease Models, Animal, DNA Damage, DNA Repair, Humans, Neoplasms, Radiation-Induced, Skin Neoplasms, Ultraviolet Rays, Anticarcinogenic Agents, Oxidative Stress, CD8-Positive T-Lymphocytes, Proanthocyanidins, Grape Seed Extract

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